A Genome-Wide Association Meta-Analysis of Circulating Sex Hormone–Binding Globulin Reveals Multiple Loci Implicated in Sex Steroid Hormone Regulation

Diverse Roles for Sex Hormone-Binding Globulin in Reproduction

(2011) G. L. Hammond   BIOLOGY OF REPRODUCTION

Associations of common polymorphisms in GCKR with type 2 diabetes and related traits in a Han Chinese population: a case-control study

(2011) Yan Ling et al.   BMC Medical Genetics

Genome-wide association studies (GWAS): impact on elucidating the aetiology of diabetes

(2011) Hakon Hakonarson et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Circulating Testosterone and SHBG Concentrations Are Heritable in Women: The Framingham Heart Study

(2011) A. D. Coviello et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

(2011) Zhibin Hu et al.   NATURE GENETICS

Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma

(2011) John C Chambers et al.   NATURE GENETICS

Glucokinase Regulatory Protein Genetic Variant Interacts with Omega-3 PUFA to Influence Insulin Resistance and Inflammation in Metabolic Syndrome

(2011) Pablo Perez-Martinez et al.   PLoS One

Genetic Determinants of Serum Testosterone Concentrations in Men

(2011) Claes Ohlsson et al.   PLoS Genetics

Hepatic Hepatocyte Nuclear Factor 4α Is Essential for Maintaining Triglyceride and Cholesterol Homeostasis

(2010) Liya Yin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

TRIB1 and GCKR Polymorphisms, Lipid Levels, and Risk of Ischemic Heart Disease in the General Population

(2010) Anette Varbo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Nuclear Receptors in Leydig Cell Gene Expression and Function1

(2010) Luc J. Martin et al.   BIOLOGY OF REPRODUCTION

GCKR gene functional variants in type 2 diabetes and metabolic syndrome: do the rare variants associate with increased carotid intima-media thickness?

(2010) Márton Mohás et al.   Cardiovascular Diabetology

MicroRNA-27a Indirectly Regulates Estrogen Receptor α Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells

(2010) Xiangrong Li et al.   ENDOCRINOLOGY

CBFA2T3-ZNF651, like CBFA2T3-ZNF652, functions as a transcriptional corepressor complex

(2010) Raman Kumar et al.   FEBS LETTERS

Loci From a Genome-Wide Analysis of Bilirubin Levels Are Associated With Gallstone Risk and Composition

(2010) Stephan Buch et al.   GASTROENTEROLOGY

Glucokinase-activating GCKR Polymorphisms Increase Plasma Levels of Triglycerides and Free Fatty Acids, but do not Elevate Cardiovascular Risk in the Ludwigshafen Risk and Cardiovascular Health Study

(2010) D. H. Kozian et al.   HORMONE AND METABOLIC RESEARCH

The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population

(2010) Hiroshi Onuma et al.   JOURNAL OF HUMAN GENETICS

Genetic variation in the GCKR gene is associated with non-alcoholic fatty liver disease in Chinese people

(2010) Zhen Yang et al.   MOLECULAR BIOLOGY REPORTS

GT-094, a NO-NSAID, Inhibits Colon Cancer Cell Growth by Activation of a Reactive Oxygen Species-MicroRNA-27a: ZBTB10-Specificity Protein Pathway

(2010) S. S. Pathi et al.   MOLECULAR CANCER RESEARCH

Suppression of ERα Activity by COUP-TFII Is Essential for Successful Implantation and Decidualization

(2010) Dong-Kee Lee et al.   MOLECULAR ENDOCRINOLOGY

GCKR mutations in Japanese families with clustered type 2 diabetes

(2010) Daisuke Tanaka et al.   MOLECULAR GENETICS AND METABOLISM

Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

(2010) Zi-Jiang Chen et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Protein arginine methyltransferase 6 regulates multiple aspects of gene expression

(2010) Matthew J. Harrison et al.   NUCLEIC ACIDS RESEARCH

Co-expression of the androgen receptor and the transcription factor ZNF652 is related to prostate cancer outcome

(2010) Callen   ONCOLOGY REPORTS

Effects of GCK, GCKR, G6PC2 and MTNR1B Variants on Glucose Metabolism and Insulin Secretion

(2010) Cheng Hu et al.   PLoS One

Association of GCKR rs780094, alone or in combination with GCK rs1799884, with type 2 diabetes and related traits in a Han Chinese population

(2009) Q. Qi et al.   DIABETOLOGIA

Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk

(2009) E. Reiling et al.   DIABETOLOGIA

Common variants at the GCK, GCKR, G6PC2–ABCB11 and MTNR1B loci are associated with fasting glucose in two Asian populations

(2009) F. Takeuchi et al.   DIABETOLOGIA

Peroxisome-Proliferator Receptor γ Represses Hepatic Sex Hormone-Binding Globulin Expression

(2009) David M. Selva et al.   ENDOCRINOLOGY

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

(2009) John R.B. Perry et al.   HUMAN MOLECULAR GENETICS

Copy-number variations (CNVs) of the human sex steroid metabolizing genesUGT2B17andUGT2B28and their associations with aUGT2B15functional polymorphism

(2009) Vincent Ménard et al.   HUMAN MUTATION

Thyroid hormones act indirectly to increase sex hormone-binding globulin production by liver via hepatocyte nuclear factor-4α

(2009) David M Selva et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Women and Men

(2009) Eric L. Ding et al.   NEW ENGLAND JOURNAL OF MEDICINE

Forty-Three Loci Associated with Plasma Lipoprotein Size, Concentration, and Cholesterol Content in Genome-Wide Analysis

(2009) Daniel I. Chasman et al.   PLoS Genetics

Identification of Common Variants in the SHBG Gene Affecting Sex Hormone-Binding Globulin Levels and Breast Cancer Risk in Postmenopausal Women

(2008) D. J. Thompson et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) and Glucokinase Regulatory Protein (GCKR) on Metabolic Traits in Healthy Chinese Adults and Adolescents

(2008) C. H.T. Tam et al.   DIABETES

Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C-Reactive Protein but Lower Fasting Glucose Concentrations

(2008) M. Orho-Melander et al.   DIABETES

SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

A Genome-Wide Association Study Identifies Protein Quantitative Trait Loci (pQTLs)

(2008) David Melzer et al.   PLoS Genetics