Implications of alternative routes to APC/C inhibition by the mitotic checkpoint complex

Cells Escape an Operational Mitotic Checkpoint through a Stochastic Process

(2018) Paolo Bonaiuti et al.   CURRENT BIOLOGY

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

A Dynamical Model for Activating and Silencing the Mitotic Checkpoint

(2017) Richard Henze et al.   Scientific Reports

Spindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint

(2016) Jing Chen et al.   BIOPHYSICAL JOURNAL

Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression

(2016) Laura C. Funk et al.   DEVELOPMENTAL CELL

The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C

(2016) Barbara Di Fiore et al.   MOLECULAR CELL

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

Intermediates in the assembly of mitotic checkpoint complexes and their role in the regulation of the anaphase-promoting complex

(2016) Sharon Kaisari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phylogenomics-guided discovery of a novel conserved cassette of short linear motifs in BubR1 essential for the spindle checkpoint

(2016) Eelco Tromer et al.   Open Biology

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

Targeting Mitosis in Cancer: Emerging Strategies

(2015) Carmen Dominguez-Brauer et al.   MOLECULAR CELL

A comprehensive analysis of CDC20 overexpression in common malignant tumors from multiple organs: its correlation with tumor grade and stage

(2015) Mariana F. Gayyed et al.   TUMOR BIOLOGY

Cdc20 and securin overexpression predict short-term breast cancer survival

(2014) H Karra et al.   BRITISH JOURNAL OF CANCER

MAD2 and CDC20 are Upregulated in High-grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix

(2014) Younghye Kim et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY

The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis

(2014) Laura A. Diaz-Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

(2014) Daisuke Izawa et al.   NATURE

Molecular architecture and mechanism of the anaphase-promoting complex

(2014) Leifu Chang et al.   NATURE

Spatial-temporal model for silencing of the mitotic spindle assembly checkpoint

(2014) Jing Chen et al.   Nature Communications

An Overview of the Spindle Assembly Checkpoint Status in Oral Cancer

(2014) José Henrique Teixeira et al.   Biomed Research International

Cdc20: A Potential Novel Therapeutic Target for Cancer Treatment

(2013) Zhiwei Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

CDC20 overexpression predicts a poor prognosis for patients with colorectal cancer

(2013) Wen-jing Wu et al.   Journal of Translational Medicine

Determinants of robustness in spindle assembly checkpoint signalling

(2013) Stephanie Heinrich et al.   NATURE CELL BIOLOGY

High expression of spindle assembly checkpoint proteins CDC20 and MAD2 is associated with poor prognosis in urothelial bladder cancer

(2013) Jung-Woo Choi et al.   VIRCHOWS ARCHIV

Role of the Mad2 Dimerization Interface in the Spindle Assembly Checkpoint Independent of Kinetochores

(2012) Luca Mariani et al.   CURRENT BIOLOGY

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Increased CDC20 expression is associated with pancreatic ductal adenocarcinoma differentiation and progression

(2012) David Z Chang et al.   Journal of Hematology & Oncology

Overexpression of CDC20 predicts poor prognosis in primary non-small cell lung cancer patients

(2012) Tatsuya Kato et al.   JOURNAL OF SURGICAL ONCOLOGY

The APC/C Subunit Mnd2/Apc15 Promotes Cdc20 Autoubiquitination and Spindle Assembly Checkpoint Inactivation

(2012) Scott A. Foster et al.   MOLECULAR CELL

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

The spindle-assembly checkpoint and the beauty of self-destruction

(2012) Andrea Musacchio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Probing thein vivofunction of Mad1:C-Mad2 in the spindle assembly checkpoint

(2011) Luca L Fava et al.   EMBO JOURNAL

BubR1 blocks substrate recruitment to the APC/C in a KEN-box-dependent manner

(2011) Pablo Lara-Gonzalez et al.   JOURNAL OF CELL SCIENCE

System-level feedbacks make the anaphase switch irreversible

(2011) E. He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitotic cell-cycle progression is regulated by CPEB1 and CPEB4-dependent translational control

(2010) Isabel Novoa et al.   NATURE CELL BIOLOGY

Regulated degradation of the APC coactivator Cdc20

(2010) Jonathan A Robbins et al.   Cell Division

Kinetic Analysis of Mad2−Cdc20 Formation: Conformational Changes in Mad2 Are Catalyzed by a C-Mad2−Ligand Complex

(2009) Latesh Lad et al.   BIOCHEMISTRY

Evidence that Mitotic Exit Is a Better Cancer Therapeutic Target Than Spindle Assembly

(2009) Hsiao-Chun Huang et al.   CANCER CELL

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

The Influence of Catalysis on Mad2 Activation Dynamics

(2009) Marco Simonetta et al.   PLOS BIOLOGY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

The Spindle Checkpoint Functions of Mad3 and Mad2 Depend on a Mad3 KEN Box-mediated Interaction with Cdc20-Anaphase-promoting Complex (APC/C)

(2008) Matylda Sczaniecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

(2008) Rob Wolthuis et al.   MOLECULAR CELL

The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction

(2008) Jakob Nilsson et al.   NATURE CELL BIOLOGY

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

(2008) Maojun Yang et al.   PLOS BIOLOGY