A Quantitative Comparison of Anti-HIV Gene Therapy Delivered to Hematopoietic Stem Cells versus CD4+ T Cells

Gene Editing of CCR5 in Autologous CD4 T Cells of Persons Infected with HIV

(2014) Pablo Tebas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

(2013) P. M. Younan et al.   BLOOD

Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection

(2013) Gilad Doitsh et al.   NATURE

IFI16 DNA Sensor Is Required for Death of Lymphoid CD4 T Cells Abortively Infected with HIV

(2013) K. M. Monroe et al.   SCIENCE

Antiviral effects of autologous CD4 T cells genetically modified with a conditionally replicating lentiviral vector expressing long antisense to HIV

(2012) P. Tebas et al.   BLOOD

Hematopoietic-Stem-Cell-Based Gene Therapy for HIV Disease

(2012) Hans-Peter Kiem et al.   Cell Stem Cell

T-lymphocyte perturbation following large-scale apheresis and hematopoietic stem cell transplantation in HIV-infected individuals

(2012) Borislav Savkovic et al.   CLINICAL IMMUNOLOGY

Antiretroviral Treatment of Adult HIV Infection

(2012) Melanie A. Thompson et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Generation of an HIV-1-Resistant Immune System with CD34+ Hematopoietic Stem Cells Transduced with a Triple-Combination Anti-HIV Lentiviral Vector

(2012) J. E. Walker et al.   JOURNAL OF VIROLOGY

Stochastic Model of In-Vivo X4 Emergence during HIV Infection: Implications for the CCR5 Inhibitor Maraviroc

(2012) Borislav Savkovic et al.   PLoS One

Decade-Long Safety and Function of Retroviral-Modified Chimeric Antigen Receptor T Cells

(2012) J. Scholler et al.   Science Translational Medicine

HIV-1 Utilizes the CXCR4 Chemokine Receptor to Infect Multipotent Hematopoietic Stem and Progenitor Cells

(2011) Christoph C. Carter et al.   Cell Host & Microbe

Ex vivo gene therapy for HIV-1 treatment

(2011) L. J. Scherer et al.   HUMAN MOLECULAR GENETICS

HIV ENV Glycoprotein-mediated Bystander Apoptosis Depends on Expression of the CCR5 Co-receptor at the Cell Surface and ENV Fusogenic Activity

(2011) Anjali Joshi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presence of CXCR4-Using HIV-1 in Patients With Recently Diagnosed Infection: Correlates and Evidence for Transmission

(2011) Kristen Chalmet et al.   JOURNAL OF INFECTIOUS DISEASES

Cumulative Viral Load and Virologic Decay Patterns after Antiretroviral Therapy in HIV-Infected Subjects Influence CD4 Recovery and AIDS

(2011) Vincent C. Marconi et al.   PLoS One

Phase I/II Clinical Trials Using Gene-Modified Adult Hematopoietic Stem Cells for HIV: Lessons Learnt

(2011) Ronald T. Mitsuyasu et al.   Stem Cells International

Evidence for the cure of HIV infection by CCR5 32/ 32 stem cell transplantation

(2010) K. Allers et al.   BLOOD

Abortive HIV Infection Mediates CD4 T Cell Depletion and Inflammation in Human Lymphoid Tissue

(2010) Gilad Doitsh et al.   CELL

The use of cell-delivered gene therapy for the treatment of HIV/AIDS

(2010) Geoff P. Symonds et al.   IMMUNOLOGIC RESEARCH

Can HIV be cured with stem cell therapy?

(2010) Steven G Deeks et al.   NATURE BIOTECHNOLOGY

Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

(2010) Nathalia Holt et al.   NATURE BIOTECHNOLOGY

Survival of the Fittest: Positive Selection of CD4+ T Cells Expressing a Membrane-Bound Fusion Inhibitor Following HIV-1 Infection

(2010) Janine Kimpel et al.   PLoS One

In silico modeling indicates the development of HIV-1 resistance to multiple shRNA gene therapy differs to standard antiretroviral therapy

(2010) Tanya Applegate et al.   Retrovirology

RNA-Based Gene Therapy for HIV with Lentiviral Vector-Modified CD34+ Cells in Patients Undergoing Transplantation for AIDS-Related Lymphoma

(2010) D. L. DiGiusto et al.   Science Translational Medicine

Computational Models of HIV-1 Resistance to Gene Therapy Elucidate Therapy Design Principles

(2010) Sharon Aviran et al.   PLoS Computational Biology

CCR5 antagonism in HIV infection: ways, effects, and side effects

(2009) Pierre Corbeau et al.   AIDS

Inhibition of Envelope-Mediated CD4+-T-Cell Depletion by Human Immunodeficiency Virus Attachment Inhibitors

(2009) L. Alexander et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mathematical modelling of the impact of haematopoietic stem cell-delivered gene therapy for HIV

(2009) John M. Murray et al.   JOURNAL OF GENE MEDICINE

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34+ cells

(2009) Ronald T Mitsuyasu et al.   NATURE MEDICINE

The biology of CCR5 and CXCR4

(2009) Ghalib Alkhatib   Current Opinion in HIV and AIDS

Accelerated Immunodeficiency by Anti-CCR5 Treatment in HIV Infection

(2009) Ariel D. Weinberger et al.   PLoS Computational Biology

Age-matched lymphocyte subpopulation reference values in childhood and adolescence: application of exponential regression analysis

(2008) Sabine Huenecke et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides

(2008) R C Zahn et al.   GENE THERAPY

Emergence and Persistence of CXCR4‐Tropic HIV‐1 in a Population of Men from the Multicenter AIDS Cohort Study

(2008) James C. Shepherd et al.   JOURNAL OF INFECTIOUS DISEASES

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

(2008) Elena E Perez et al.   NATURE BIOTECHNOLOGY

Subgroup Analyses of Maraviroc in Previously Treated R5 HIV-1 Infection

(2008) Gerd Fätkenheuer et al.   NEW ENGLAND JOURNAL OF MEDICINE