Non-catalytic tyrosine-phosphorylated receptors

Antigen Sensitivity of CD22-Specific Chimeric TCR Is Modulated by Target Epitope Distance from the Cell Membrane

(2014) S. E. James et al.   JOURNAL OF IMMUNOLOGY

Mechanical Modulation of Receptor-Ligand Interactions at Cell-Cell Interfaces

(2012) Jun F. Allard et al.   BIOPHYSICAL JOURNAL

Kinetics and Mechanics of Two-Dimensional Interactions between T Cell Receptors and Different Activating Ligands

(2012) Philippe Robert et al.   BIOPHYSICAL JOURNAL

Role of ITAM signaling module in signal integration

(2012) Jelena S Bezbradica et al.   CURRENT OPINION IN IMMUNOLOGY

SAP Signaling: A Dual Mechanism of Action

(2012) Marie Le Borgne et al.   IMMUNITY

The Dendritic Cell Receptor Clec9A Binds Damaged Cells via Exposed Actin Filaments

(2012) Jian-Guo Zhang et al.   IMMUNITY

Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2

(2012) Tadashi Yokosuka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Actin' dangerously

(2012) Gordon D. Brown   NATURE

Photocrosslinkable pMHC monomers stain T cells specifically and cause ligand-bound TCRs to be 'preferentially' transported to the cSMAC

(2012) Jianming Xie et al.   NATURE IMMUNOLOGY

Mechanical Force in T Cell Receptor Signal Initiation

(2012) Zhengyu Ma et al.   Frontiers in Immunology

SLAM Family Receptors and SAP Adaptors in Immunity

(2011) Jennifer L. Cannons et al.   Annual Review of Immunology

Ultrasensitivity in Multisite Phosphorylation of Membrane-Anchored Proteins

(2011) Omer Dushek et al.   BIOPHYSICAL JOURNAL

Myeloid C-type Lectin Receptors in Pathogen Recognition and Host Defense

(2011) Fabiola Osorio et al.   IMMUNITY

αβ T Cell Receptors that Do Not Undergo Major Histocompatibility Complex-Specific Thymic Selection Possess Antibody-like Recognition Specificities

(2011) Anastasia N. Tikhonova et al.   IMMUNITY

Regulation of Src Family Kinases Involved in T Cell Receptor Signaling by Protein-tyrosine Phosphatase CD148

(2011) Ondrej Stepanek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the innate immune receptor Dectin-1 upon formation of a ‘phagocytic synapse’

(2011) Helen S. Goodridge et al.   NATURE

Basic residues in the T-cell receptor   cytoplasmic domain mediate membrane association and modulate signaling

(2011) H. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen Potency and Maximal Efficacy Reveal a Mechanism of Efficient T Cell Activation

(2011) O. Dushek et al.   Science Signaling

CLEC-2 activates Syk through dimerization

(2010) C. E. Hughes et al.   BLOOD

What Controls T Cell Receptor Phosphorylation?

(2010) Ricardo A. Fernandes et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Ligand dimensions are important in controlling NK-cell responses

(2010) Joanna Brzostek et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dependence of T Cell Antigen Recognition on T Cell Receptor-Peptide MHC Confinement Time

(2010) Milos Aleksic et al.   IMMUNITY

Constitutively Active Lck Kinase in T Cells Drives Antigen Receptor Signal Transduction

(2010) Konstantina Nika et al.   IMMUNITY

Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation

(2010) Tadashi Yokosuka et al.   IMMUNITY

Cutting Edge: NKp80 Uses an Atypical Hemi-ITAM To Trigger NK Cytotoxicity

(2010) K. M. Dennehy et al.   JOURNAL OF IMMUNOLOGY

T-Cell Receptor Microclusters Critical for T-Cell Activation Are Formed Independently of Lipid Raft Clustering

(2010) A. Hashimoto-Tane et al.   MOLECULAR AND CELLULAR BIOLOGY

The kinetics of two-dimensional TCR and pMHC interactions determine T-cell responsiveness

(2010) Jun Huang et al.   NATURE

TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity

(2010) Johannes B. Huppa et al.   NATURE

Revitalizing membrane rafts: new tools and insights

(2010) Kai Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Matched Sizes of Activating and Inhibitory Receptor/Ligand Pairs Are Required for Optimal Signal Integration by Human Natural Killer Cells

(2010) Karsten Köhler et al.   PLoS One

Fast on-rates allow short dwell time ligands to activate T cells

(2010) C. C. Govern et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Structural and Functional Studies of Igαβ and Its Assembly with the B Cell Antigen Receptor

(2010) Sergei Radaev et al.   STRUCTURE

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells

(2009) Jayajit Das et al.   CELL

Discovery of a functional immunoreceptor tyrosine-based switch motif in a 7-transmembrane-spanning receptor: role in the orexin receptor OX1R-driven apoptosis

(2009) Aadil El Firar et al.   FASEB JOURNAL

Multisite protein phosphorylation - from molecular mechanisms to kinetic models

(2009) Carlos Salazar et al.   FEBS Journal

CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells

(2009) Michelle L. Hermiston et al.   IMMUNOLOGICAL REVIEWS

Importance and mechanism of ‘switch’ function of SAP family adapters

(2009) André Veillette et al.   IMMUNOLOGICAL REVIEWS

Peptide-Major Histocompatibility Complex Dimensions Control Proximal Kinase-Phosphatase Balance during T Cell Activation

(2009) Kaushik Choudhuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unlimited multistability in multisite phosphorylation systems

(2009) Matthew Thomson et al.   NATURE

A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen

(2009) Omer Dushek et al.   PLoS Computational Biology

A Mechanism for Src Kinase-Dependent Signaling by Noncatalytic Receptors†

(2008) Jonathan A. Cooper et al.   BIOCHEMISTRY

Measuring Diffusion and Binding Kinetics by Contact Area FRAP

(2008) Timothy P. Tolentino et al.   BIOPHYSICAL JOURNAL

Analysis of Serial Engagement and Peptide-MHC Transport in T Cell Receptor Microclusters

(2008) Omer Dushek et al.   BIOPHYSICAL JOURNAL

Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif

(2008) Chenqi Xu et al.   CELL

Spatiotemporal Regulation of T Cell Costimulation by TCR-CD28 Microclusters and Protein Kinase C θ Translocation

(2008) Tadashi Yokosuka et al.   IMMUNITY

DAP10- and DAP12-associated receptors in innate immunity

(2008) Lewis L. Lanier   IMMUNOLOGICAL REVIEWS

Direct observation of the nanoscale dynamics of membrane lipids in a living cell

(2008) Christian Eggeling et al.   NATURE

Src family kinases: Regulation of their activities, levels and identification of new pathways

(2007) Evan Ingley   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Src Family Kinases and Receptors: Analysis of Three Activation Mechanisms by Dynamic Systems Modeling

(2007) Hendrik Fuß et al.   BIOPHYSICAL JOURNAL