Using Functional Signatures to Identify Repositioned Drugs for Breast, Myelogenous Leukemia and Prostate Cancer

Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk

(2011) Tun-Hsiang Yang et al.   BMC Medical Genomics

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data

(2011) M. Sirota et al.   Science Translational Medicine

T-cell receptor gene transfer for the treatment of leukemia and other tumors

(2010) M. H.M. Heemskerk   HAEMATOLOGICA

TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

(2010) Kazuhito Naka et al.   NATURE

A global map of human gene expression

(2010) Margus Lukk et al.   NATURE BIOTECHNOLOGY

Virtual screening: an endless staircase?

(2010) Gisbert Schneider   NATURE REVIEWS DRUG DISCOVERY

Discovery of drug mode of action and drug repositioning from transcriptional responses

(2010) F. Iorio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TGF-β suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB

(2009) George M. Risinger et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Network analyses in systems pharmacology

(2009) S. I. Berger et al.   BIOINFORMATICS

The direct effect of Focal Adhesion Kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis

(2009) Vita M Golubovskaya et al.   BMC CANCER

Systematic Evaluation of Drug–Disease Relationships to Identify Leads for Novel Drug Uses

(2009) A P Chiang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Enhanced interaction between focal adhesion and adherens junction proteins: Involvement in sphingosine 1-phosphate-induced endothelial barrier enhancement

(2009) Xiaoguang Sun et al.   MICROVASCULAR RESEARCH

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

A network view of disease and compound screening

(2009) Eric E. Schadt et al.   NATURE REVIEWS DRUG DISCOVERY

VisANT 3.5: multi-scale network visualization, analysis and inference based on the gene ontology

(2009) Zhenjun Hu et al.   NUCLEIC ACIDS RESEARCH

Human Disease-Drug Network Based on Genomic Expression Profiles

(2009) Guanghui Hu et al.   PLoS One

Dysregulation of Ribosome Biogenesis and Translational Capacity Is Associated with Tumor Progression of Human Breast Cancer Cells

(2009) Stéphane Belin et al.   PLoS One

Genome-wide prioritization of disease genes and identification of disease-disease associations from an integrated human functional linkage network

(2009) Bolan Linghu et al.   GENOME BIOLOGY

Tamoxifen decreases extracellular TGF-β1 secreted from breast cancer cells — A post-translational regulation involving matrix metalloproteinase activity

(2008) Ulrika W Nilsson et al.   EXPERIMENTAL CELL RESEARCH

Nucleotide excision repair polymorphisms may modify ionizing radiation-related breast cancer risk in US radiologic technologists

(2008) Preetha Rajaraman et al.   INTERNATIONAL JOURNAL OF CANCER

Role of Ras Signaling in the Induction of Snail by Transforming Growth Factor-β

(2008) Kana Horiguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology

Drug Target Identification Using Side-Effect Similarity

(2008) M. Campillos et al.   SCIENCE