Article
Biochemistry & Molecular Biology
Amandine Jullienne, Ryan Quan, Jenny Szu, Michelle Trinh, Erik J. Behringer, Andre Obenaus
Summary: This study utilized the 3xTg-AD mouse model to examine the role of vascular dysfunction and structural abnormalities in the progression of Alzheimer's disease. The findings demonstrate progressive alterations in individual cortical vessels and the cortical vascular network, potentially identifying unique diagnostic signatures of AD progression.
Article
Neurosciences
Dominic I. Javonillo, Kristine M. Tran, Jimmy Phan, Edna Hingco, Enikoe A. Kramar, Celia da Cunha, Stefania Forner, Shimako Kawauchi, Giedre Milinkeviciute, Angela Gomez-Arboledas, Jonathan Neumann, Crystal E. Banh, Michelle Huynh, Dina P. Matheos, Narges Rezaie, Joshua A. Alcantara, Ali Mortazavi, Marcelo A. Wood, Andrea J. Tenner, Grant R. MacGregor, Kim N. Green, Frank M. LaFerla
Summary: Animal models are important for studying disease mechanisms and potential treatments, but the availability of numerous animal models presents challenges for Alzheimer's disease (AD) researchers. In this study, the 3xTg-AD mouse model was analyzed to understand the specific pathologies that develop at different ages and to comment on changes since its development 20 years ago. The study also compared the 3xTg-AD model with the 5xFAD model and found that plasma NfL is influenced by plaque burden. The results are freely available for researchers and demonstrate the usefulness of a standardized characterization pipeline for investigating and comparing different AD models.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Jessica L. Dennison, Claude-Henry Volmar, Danbing Ke, James Wang, Emilie Gravel, Sabrina Hammond-Vignini, Zuomei Li, James A. Timmons, Ines Lohse, Marshall A. Hayward, Shaun P. Brothers, Claes Wahlestedt
Summary: JOTROL, a novel oral formulation of resveratrol, has higher bioavailability compared to non-formulated resveratrol. It has been found to be effective in the prevention and treatment of AD by regulating AD-related gene expression, inhibiting inflammatory genes, and regulating cytokine levels.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jessica Dennison, Armando Mendez, Angela Szeto, Ines Lohse, Claes Wahlestedt, Claude-Henry Volmar
Summary: This study investigated the effects of a histone deacetylase inhibitor, chidamide, on male and female mice in an AD model. The results showed that chidamide treatment significantly improved glucose tolerance and increased expression of glucose transporters in the brains of male mice. Furthermore, the expression of genes involved in the neuroinflammatory pathway and amyloid processing pathway showed different patterns between male and female mice after chidamide treatment.
Article
Biochemistry & Molecular Biology
Chiara Magri, Erika Vitali, Sara Cocco, Edoardo Giacopuzzi, Marco Rinaudo, Paolo Martini, Alessandro Barbon, Claudio Grassi, Massimo Gennarelli
Summary: This study provides a comprehensive molecular characterization of the 3xTg-AD mouse and suggests that blood gene expression may serve as new biomarkers for identifying AD progression and treatment effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lidia Castillo-Mariqueo, M. Jose Perez-Garcia, Lydia Gimenez-Llort
Summary: The study on the 3xTg-AD mouse model reveals significant functional impairments in gait and exploratory activity in patients with Alzheimer's disease, which worsen with disease severity and aging. This indicates the potential for using the ICF framework in rehabilitation and understanding of functional decline in AD patients.
Article
Neurosciences
Olivier Landry, Arnaud Francois, Meryl-Farelle Oye Mintsa Mi-Mba, Marie-Therese Traversy, Cyntia Tremblay, Vincent Emond, David A. Bennett, Karen H. Gylys, Joseph D. Buxbaum, Frederic Calon
Summary: Synaptic loss is closely related to Alzheimer's disease (AD) neuropathology and symptoms. The deficiency of Shank3 protein is associated with severe cognitive symptoms in children. This study found that the loss of Shank3a in the parietal cortex of individuals with AD is associated with cognitive decline. The deficiency of Shank3a in AD mice exacerbates cognitive impairment and anxious behavior.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chandramouli Natarajan, Charles Cook, Karthik Ramaswamy, Balaji Krishnan
Summary: Attenuating PLD1 expression has neurotherapeutic implications in tauopathies, as it can alleviate synaptic dysfunction and memory deficits. In mouse models, the use of PLD1 inhibitors improved cognitive function and preserved synaptic morphology, suggesting potential clinical applications for Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Lisa S. Robison, Olivia J. Gannon, Abigail E. Salinero, Charly Abi-Ghanem, Richard D. Kelly, David A. Riccio, Febronia M. Mansour, Kristen L. Zuloaga
Summary: Alzheimer's disease is associated with cognitive decline and affects multiple brain regions. The hypothalamus, which controls energy and glucose homeostasis, is also affected. Changes in metabolism may serve as biomarkers for Alzheimer's disease and contribute to disease progression. In this study, sex differences in metabolic disturbances and hypothalamic inflammation were observed in Alzheimer's disease mice.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Behavioral Sciences
Ugne Simanaviciute, Richard E. Brown, Aimee Wong, Emre Fertan, Robyn A. Grant
Summary: Alzheimer's disease is the most common form of dementia in elderly people. The triple transgenic (3xTg-AD) mouse model is important for studying Alzheimer's disease as it exhibits both neuropathological and behavioral phenotypes. Whisker movements can reflect motor, sensory, and cognitive deficits in mouse models of neurodegenerative disease.
GENES BRAIN AND BEHAVIOR
(2022)
Article
Neurosciences
Amanda Ferreira Neves, Christian Camargo, Courtney Premer, Joshua M. Hare, Bernard S. Baumel, Milena Pinto
Summary: The study demonstrates that the timing and frequency of MSC injections can impact various aspects of AD-like neuropathology in the 3xTg-AD mouse model. Single-dose MSC injections in young mice reduced neuroinflammation, while multiple doses affected beta-secretase cleavage and tau phosphorylation. Multiple-dose MSC injections also showed differing effects on tau phosphorylation at different sites in young and old mice.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Neurosciences
Jessica L. Dennison, Natalie R. Ricciardi, Ines Lohse, Claude-Henry Volmar, Claes Wahlestedt
Summary: This study thoroughly analyzed the sexually dimorphic characteristics in the 3xTg-AD model, revealing inconsistent results attributed to differing methodologies and strain sources, often overlooked in research. The authors suggest unifying pre-clinical mouse model AD research by considering sex as a biological variable.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Yajing Liu, Jinjing Yao, Zhenpeng Song, Wenting Guo, Bo Sun, Jinhong Wei, John Paul Estillore, Thomas G. Back, S. R. Wayne Chen
Summary: Research suggests that limiting neuronal hyperactivity may halt the progression of Alzheimer's disease, particularly in rapidly developing AD mouse models. This approach has also shown promise in preventing deficits related to learning and memory in a slow-developing AD mouse model that more closely resembles human AD.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Neurosciences
Kelly Ceyzeriat, Benjamin B. Tournier, Philippe Millet, Giovanna Dipasquale, Nikolaos Koutsouvelis, Giovanni B. Frisoni, Valentina Garibotto, Thomas Zilli
Summary: This study found that low-dose radiation therapy (LD-RT) reduced amyloid load and possibly neuroinflammation markers in early-stage Alzheimer's disease, but did not impact tauopathy.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Daniel Alveal-Mellado, Lidia Castillo-Mariqueo, Lydia Gimenez-Llort
Summary: The study showed that mice with exercise training exhibited higher levels of horizontal exploration in the open field test. There were sex-dependent differences in voluntary wheel running activity, with high-NIBI males running less than high-NIBI females. This may be influenced by NPS-like symptoms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Kurt R. Stover, Mackenzie A. Campbell, Christine M. Van Winssen, Richard E. Brown
BEHAVIOURAL BRAIN RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Jillian L. King, Matthew P. Lowe, Kurt R. Stover, Aimee A. Wong, Nathan A. Crowder
Article
Chemistry, Medicinal
Michael G. Brant, Jake Goodwin-Tindall, Kurt R. Stover, Paul M. Stafford, Fan Wu, Autumn R. Meek, Paolo Schiavini, Stephanie Wohnig, Donald F. Weaver
ACS MEDICINAL CHEMISTRY LETTERS
(2018)
Article
Behavioral Sciences
Kurt R. Stover, Richard E. Brown
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Behavioral Sciences
Caitlin E. Blaney, Rhian K. Gunn, Kurt R. Stover, Richard E. Brown
BEHAVIOURAL BRAIN RESEARCH
(2013)
Article
Neurosciences
Emily E. LeDue, Jillian L. King, Kurt R. Stover, Nathan A. Crowder
FRONTIERS IN NEURAL CIRCUITS
(2013)
Article
Behavioral Sciences
Thalia Garvock-de Montbrun, Emre Fertan, Kurt Stover, Richard E. Brown
BEHAVIOURAL BRAIN RESEARCH
(2019)
Article
Behavioral Sciences
Timothy P. O'Leary, Hector M. Mantolino, Kurt R. Stover, Richard E. Brown
GENES BRAIN AND BEHAVIOR
(2020)
Article
Pharmacology & Pharmacy
Haiyu Liu, Kurt R. Stover, Nila Sivanenthiran, Jonathan Chow, Chloe Cheng, Yapeng Liu, Stellar Lim, Chiping Wu, Donald F. Weaver, James H. Eubanks, Hongmei Song, Liang Zhang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Emre Fertan, Kurt R. J. Stover, Michael G. Brant, Paul M. Stafford, Brendan Kelly, Elena Diez-Cecilia, Aimee A. Wong, Donald F. Weaver, Richard E. Brown
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Behavioral Sciences
T. P. O'Leary, K. R. Stover, H. M. Mantolino, S. Darvesh, R. E. Brown
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Chemistry, Medicinal
Yong Zheng, Paul M. Stafford, Kurt R. Stover, Darapaneni Chandra Mohan, Mayuri Gupta, Eric C. Keske, Paolo Schiavini, Laura Villar, Fan Wu, Alexander Kreft, Kiersten Thomas, Elana Raaphorst, Jagadeesh P. Pasangulapati, Siva R. Alla, Simmi Sharma, Ramana R. Mittapalli, Irina Sagamanova, Shea L. Johnson, Mark A. Reed, Donald F. Weaver
Summary: IDO1 is a promising therapeutic target for cancer immunotherapy and neurological diseases, and there is ongoing research and development efforts to find highly active inhibitors for human cancers. This study reports the design of novel IDO1 inhibitors based on previous research, with one compound showing strong inhibitory activity. Computational simulations suggest that a hydroxyl group interacts favorably with a specific residue in the protein structure, improving inhibitory potency, and several compounds were found to be brain penetrant with promising pharmacokinetic profiles.
Article
Chemistry, Medicinal
Zhiyu Wang, Yanfei Wang, Jagadeesh Prasad Pasangulapati, Kurt R. Stover, Xiaojing Liu, Stephanie (Wohnig) Schier, Donald F. Weaver
Summary: This study reports a series of furosemide analogs that target both A beta aggregation and neuroinflammation, addressing the combined proteopathic-immunopathic pathogenesis of Alzheimer's disease. These compounds demonstrate dual activity against A beta aggregation and neuroinflammation, suggesting potential therapeutic utility against Alzheimer's disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Neurosciences
Kurt R. Stover, Stellar Lim, Terri-Lin Zhou, Paul M. Stafford, Jonathan Chow, Haoyuan Li, Nila Sivanenthiran, Sivakami Mylvaganam, Chiping Wu, Donald F. Weaver, James Eubanks, Liang Zhang
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)