The host immune dynamics of pneumococcal colonization: Implications for novel vaccine development

Impact of 13-Valent Pneumococcal Conjugate Vaccination in Invasive Pneumococcal Disease Incidence and Mortality

(2014) Zitta Barrella Harboe et al.   CLINICAL INFECTIOUS DISEASES

Trends in Asymptomatic Nasopharyngeal Colonization With Streptococcus pneumoniae After Introduction of the 13-valent Pneumococcal Conjugate Vaccine in Calgary, Canada

(2014) Leah J. Ricketson et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Direct and Indirect Effects of PCV13 on Nasopharyngeal Carriage of PCV13 Unique Pneumococcal Serotypes in Massachusetts’ Children

(2014) Anita M. Loughlin et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Changes in Childhood Pneumonia and Infant Mortality Rates Following Introduction of the 13-valent Pneumococcal Conjugate Vaccine in Nicaragua

(2014) Sylvia Becker-Dreps et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Immunogenicity, Impact on Carriage and Reactogenicity of 10-Valent Pneumococcal Non-Typeable Haemophilus influenzae Protein D Conjugate Vaccine in Kenyan Children Aged 1–4 Years: A Randomized Controlled Trial

(2014) Laura L. Hammitt et al.   PLoS One

Challenges in vaccination of neonates, infants and young children

(2014) Michael E. Pichichero   VACCINE

Impact of 10-valent pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine (PHiD-CV) on childhood pneumonia hospitalizations in Brazil two years after introduction

(2014) Marcelo Comerlato Scotta et al.   VACCINE

Safety, reactogenicity and immunogenicity of a novel pneumococcal protein-based vaccine in adults: A phase I/II randomized clinical study

(2014) Geert Leroux-Roels et al.   VACCINE

Vaccination with a Streptococcus pneumoniae trivalent recombinant PcpA, PhtD and PlyD1 protein vaccine candidate protects against lethal pneumonia in an infant murine model

(2014) David Verhoeven et al.   VACCINE

Safety and immunogenicity of an investigational vaccine containing two common pneumococcal proteins in toddlers: A phase II randomized clinical trial

(2014) Roman Prymula et al.   VACCINE

Controlled Human Infection and Rechallenge withStreptococcus pneumoniaeReveals the Protective Efficacy of Carriage in Healthy Adults

(2013) Daniela M. Ferreira et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Comparative Immunogenicity and Efficacy of 13-Valent and 7-Valent Pneumococcal Conjugate Vaccines in Reducing Nasopharyngeal Colonization: A Randomized Double-Blind Trial

(2013) Ron Dagan et al.   CLINICAL INFECTIOUS DISEASES

Five-year prospective study of paediatric acute otitis media in Rochester, NY: modelling analysis of the risk of pneumococcal colonization in the nasopharynx and infection

(2013) V. FRIEDEL et al.   EPIDEMIOLOGY AND INFECTION

CD4 T Cell Memory and Antibody Responses Directed against the Pneumococcal Histidine Triad Proteins PhtD and PhtE following Nasopharyngeal Colonization and Immunization and Their Role in Protection against Pneumococcal Colonization in Mice

(2013) M. N. Khan et al.   INFECTION AND IMMUNITY

Polysaccharide-Specific Memory B Cells Generated by Conjugate Vaccines in Humans Conform to the CD27+IgG+ Isotype-Switched Memory B Cell Phenotype and Require Contact-Dependent Signals from Bystander T Cells Activated by Bacterial Proteins To Differentiate into Plasma Cells

(2013) E. T. Clarke et al.   JOURNAL OF IMMUNOLOGY

Immune Dysfunction and Bacterial Coinfections following Influenza

(2013) D. W. Metzger et al.   JOURNAL OF IMMUNOLOGY

Live Attenuated Influenza Vaccine, But Not Pneumococcal Conjugate Vaccine, Protects Against Increased Density and Duration of Pneumococcal Carriage After Influenza Infection in Pneumococcal Colonized Mice

(2013) Michael J. Mina et al.   JOURNAL OF INFECTIOUS DISEASES

Activation of memory Th17 cells by domain 4 pneumolysin in human nasopharynx-associated lymphoid tissue and its association with pneumococcal carriage

(2013) C Gray et al.   Mucosal Immunology

Population genomics of post-vaccine changes in pneumococcal epidemiology

(2013) Nicholas J Croucher et al.   NATURE GENETICS

Characterization of Protective Immune Responses Induced by Pneumococcal Surface Protein A in Fusion with Pneumolysin Derivatives

(2013) Cibelly Goulart et al.   PLoS One

A Phase I, dose-escalation trial in adults of three recombinant attenuated Salmonella Typhi vaccine vectors producing Streptococcus pneumoniae surface protein antigen PspA

(2013) Sharon E. Frey et al.   VACCINE

CD4+ T-cell responses among adults and young children in response to Streptococcus pneumoniae and Haemophilus influenzae vaccine candidate protein antigens

(2013) Sharad K. Sharma et al.   VACCINE

Co-colonization by Haemophilus influenzae with Streptococcus pneumoniae enhances pneumococcal-specific antibody response in young children

(2013) Qingfu Xu et al.   VACCINE

Protein carriers of conjugate vaccines: Characteristics, development and clinical trials

(2013) Michael E Pichichero   Human Vaccines & Immunotherapeutics

Kinetics of Coinfection with Influenza A Virus and Streptococcus pneumoniae

(2013) Amber M. Smith et al.   PLoS Pathogens

Experimental Human Pneumococcal Carriage Augments IL-17A-dependent T-cell Defence of the Lung

(2013) Adam K. A. Wright et al.   PLoS Pathogens

Viral and Bacterial Interactions in the Upper Respiratory Tract

(2013) Astrid A. T. M. Bosch et al.   PLoS Pathogens

Co-infection subverts mucosal immunity in the upper respiratory tract

(2012) Rebeccah S Lijek et al.   CURRENT OPINION IN IMMUNOLOGY

Use of the 13-valent pneumococcal conjugate vaccine in infants and young children

(2012) Nicola Principi et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship?

(2012) Kirsty R Short et al.   Future Microbiology

Innate Immune Function by Toll-like Receptors: Distinct Responses in Newborns and the Elderly

(2012) Tobias R. Kollmann et al.   IMMUNITY

PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans

(2012) M. Nadeem Khan et al.   MICROBES AND INFECTION

Impact of 13-valent Pneumococcal Conjugate Vaccine on Pneumococcal Nasopharyngeal Carriage in Children With Acute Otitis Media

(2012) Robert Cohen et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Impact of Respiratory Viral Infections on α-Hemolytic Streptococci and Otopathogens in the Nasopharynx of Young Children

(2012) Victoria Friedel et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Relationship Between Maternal and Neonatal Staphylococcus aureus Colonization

(2012) N. Jimenez-Truque et al.   PEDIATRICS

Identification of Protective Pneumococcal TH17 Antigens from the Soluble Fraction of a Killed Whole Cell Vaccine

(2012) Kristin L. Moffitt et al.   PLoS One

Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans

(2012) M. Nadeem Khan et al.   VACCINE

Characterization of Th17 responses to Streptococcus pneumoniae in humans: Comparisons between adults and children in a developed and a developing country

(2012) Anna Lundgren et al.   VACCINE

Safety and immunogenicity of pneumococcal protein vaccine candidates: Monovalent choline-binding protein A (PcpA) vaccine and bivalent PcpA–pneumococcal histidine triad protein D vaccine

(2012) Monica Bologa et al.   VACCINE

Antibody response toStreptococcus pneumoniaeproteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children

(2012) Michael E. Pichichero et al.   Human Vaccines & Immunotherapeutics

TH17 Cells in Autoimmunity and Immunodeficiency: Protective or Pathogenic?

(2012) Ashish K. Marwaha et al.   Frontiers in Immunology

RrgB321, a Fusion Protein of the Three Variants of the Pneumococcal Pilus Backbone RrgB, Is ProtectiveIn Vivoand Elicits Opsonic Antibodies

(2011) Carole Harfouche et al.   INFECTION AND IMMUNITY

Viral-Bacterial Interactions and Risk of Acute Otitis Media Complicating Upper Respiratory Tract Infection

(2011) Melinda M. Pettigrew et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The NLRP3 Inflammasome Is Differentially Activated by Pneumolysin Variants and Contributes to Host Defense in Pneumococcal Pneumonia

(2011) M. Witzenrath et al.   JOURNAL OF IMMUNOLOGY

Reduced Memory CD4+ T-Cell Generation in the Circulation of Young Children May Contribute to the Otitis-Prone Condition

(2011) Sharad K. Sharma et al.   JOURNAL OF INFECTIOUS DISEASES

Nasopharyngeal Pneumococcal Carriage of Children Attending Day Care Centers in Korea: Comparison between Children Immunized with 7-valent Pneumococcal Conjugate Vaccine and Non-immunized

(2011) Kyung-Hyo Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Potential Benefits From Currently Available Three Pneumococcal Vaccines for Children - Population-Based Evaluation

(2011) S. Rückinger et al.   KLINISCHE PADIATRIE

Serum Antibody Response to Five Streptococcus pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non–otitis-prone Children

(2011) Ravinder Kaur et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Protective Contributions against Invasive Streptococcus pneumoniae Pneumonia of Antibody and Th17-Cell Responses to Nasopharyngeal Colonisation

(2011) Jonathan M. Cohen et al.   PLoS One

Rapid Pneumococcal Evolution in Response to Clinical Interventions

(2011) N. J. Croucher et al.   SCIENCE

Mother–infant vaccination with pneumococcal polysaccharide vaccine: Persistence of maternal antibodies and responses of infants to vaccination

(2011) Emma Holmlund et al.   VACCINE

Predominance of nontypeable Haemophilus influenzae in children with otitis media following introduction of a 3+0 pneumococcal conjugate vaccine schedule

(2011) Selma P. Wiertsema et al.   VACCINE

Impact of the 10-valent pneumococcal non-typeable Haemophilus influenzae Protein D conjugate vaccine (PHiD-CV) on bacterial nasopharyngeal carriage

(2011) Roman Prymula et al.   VACCINE

High Levels of Recombination among Streptococcus pneumoniae Isolates from the Gambia

(2011) E. S. Donkor et al.   mBio

Influence of pneumococcal serotype group on outcome in adults with bacteraemic pneumonia

(2010) M. Lujan et al.   EUROPEAN RESPIRATORY JOURNAL

Influenza A virus facilitates Streptococcus pneumoniae transmission and disease

(2010) Dimitri A. Diavatopoulos et al.   FASEB JOURNAL

Interaction of Pneumococcal Histidine Triad Proteins with Human Complement

(2010) M. Melin et al.   INFECTION AND IMMUNITY

Preclinical Evaluation of the Pht Proteins as Potential Cross-Protective Pneumococcal Vaccine Antigens

(2010) Fabrice Godfroid et al.   INFECTION AND IMMUNITY

Influenza Infection Leads to Increased Susceptibility to Subsequent Bacterial Superinfection by Impairing NK Cell Responses in the Lung

(2010) Cherrie-Lee Small et al.   JOURNAL OF IMMUNOLOGY

Nasopharyngeal Carriage ofStreptococcus pneumoniaeShortly before Vaccination with a Pneumococcal Conjugate Vaccine Causes Serotype‐Specific Hyporesponsiveness in Early Infancy

(2010) Ron Dagan et al.   JOURNAL OF INFECTIOUS DISEASES

Transcriptional regulation, occurrence and putative role of the Pht family of Streptococcus pneumoniae

(2010) S. Rioux et al.   MICROBIOLOGY-SGM

Immunogenicity of a Reduced Schedule of Pneumococcal Conjugate Vaccine in Healthy Infants and Correlates of Protection for Serotype 6B in the United Kingdom

(2010) David Goldblatt et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Association Between Nasopharyngeal Load of Streptococcus pneumoniae, Viral Coinfection, and Radiologically Confirmed Pneumonia in Vietnamese Children

(2010) Huong Thi Thu Vu et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children

(2010) Michael E. Pichichero et al.   VACCINE

GMP-grade pneumococcal whole-cell vaccine injected subcutaneously protects mice from nasopharyngeal colonization and fatal aspiration-sepsis

(2010) Ying-Jie Lu et al.   VACCINE

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

(2010) Edel A. McNeela et al.   PLoS Pathogens

Skewed pattern of Toll-like receptor 4-mediated cytokine production in human neonatal blood: Low LPS-induced IL-12p70 and high IL-10 persist throughout the first month of life

(2009) M.E. Belderbos et al.   CLINICAL IMMUNOLOGY

Protection against Pneumococcal Colonization and Fatal Pneumonia by a Trivalent Conjugate of a Fusion Protein with the Cell Wall Polysaccharide

(2009) Y.-J. Lu et al.   INFECTION AND IMMUNITY

Impaired Innate and Adaptive Immunity to Streptococcus pneumoniae and Its Effect on Colonization in an Infant Mouse Model

(2009) D. Bogaert et al.   INFECTION AND IMMUNITY

Neonatal Innate TLR-Mediated Responses Are Distinct from Those of Adults

(2009) T. R. Kollmann et al.   JOURNAL OF IMMUNOLOGY

T Cell Memory Response to Pneumococcal Protein Antigens in an Area of High Pneumococcal Carriage and Disease

(2009) Marianne W. Mureithi et al.   JOURNAL OF INFECTIOUS DISEASES

Pneumococcal Serotypes and Mortality following Invasive Pneumococcal Disease: A Population-Based Cohort Study

(2009) Zitta B. Harboe et al.   PLOS MEDICINE

Impairment of T helper and T regulatory cell responses at birth

(2008) B. Schaub et al.   ALLERGY

Pneumococcal Surface Adhesin A (PsaA): A Review

(2008) Gowrisankar Rajam et al.   CRITICAL REVIEWS IN MICROBIOLOGY

Pneumolysin: A Double-Edged Sword During the Host-Pathogen Interaction

(2008) Helen Marriott et al.   CURRENT MOLECULAR MEDICINE

Interleukin-17 in host defence against bacterial, mycobacterial and fungal pathogens

(2008) Meredith M. Curtis et al.   IMMUNOLOGY

Streptococcus pneumoniae Surface Protein PcpA Elicits Protection against Lung Infection and Fatal Sepsis

(2008) D. T. Glover et al.   INFECTION AND IMMUNITY

Inhibition of pulmonary antibacterial defense by interferon-γ during recovery from influenza infection

(2008) Keer Sun et al.   NATURE MEDICINE

Impact of Conjugate Vaccine on Transmission of Antimicrobial-Resistant Streptococcus pneumoniae Among Alaskan Children

(2008) Sarah Y. Park et al.   PEDIATRIC INFECTIOUS DISEASE JOURNAL

Interleukin-17A Mediates Acquired Immunity to Pneumococcal Colonization

(2008) Ying-Jie Lu et al.   PLoS Pathogens