Engineering better immunotherapies via RNA interference

The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma

(2014) Pallab Pradhan et al.   BIOMATERIALS

Dendritic Cells Loaded with Tumor Antigens and a Dual Immunostimulatory and Anti-Interleukin 10-Specific Small Interference RNA Prime T Lymphocytes against Leukemic Cells

(2014) Per O. Iversen et al.   Translational Oncology

Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

(2013) D. M. S. Hossain et al.   BLOOD

A novel peptide carrier for efficient targeting of antigens and nucleic acids to dendritic cells

(2013) Mouldy Sioud et al.   FASEB JOURNAL

MicroRNA-155 Is Required for Effector CD8+ T Cell Responses to Virus Infection and Cancer

(2013) Jan C. Dudda et al.   IMMUNITY

T-cell tolerance in cancer

(2013) Roza Nurieva et al.   Immunotherapy

Delivery materials for siRNA therapeutics

(2013) Rosemary Kanasty et al.   NATURE MATERIALS

Targeting the Cytosolic Innate Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma

(2013) Martin Glas et al.   STEM CELLS

Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation

(2012) Willemijn Hobo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Creating genetic resistance to HIV

(2012) John C Burnett et al.   CURRENT OPINION IN IMMUNOLOGY

Regulating naïve and memory CD8 T cell homeostasis - a role for protein tyrosine phosphatases

(2012) Kelly A. Pike et al.   FEBS Journal

Silencing IDO in dendritic cells: A novel approach to enhance cancer immunotherapy in a murine breast cancer model

(2012) Xiufen Zheng et al.   INTERNATIONAL JOURNAL OF CANCER

Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo

(2012) I. M. Stromnes et al.   JOURNAL OF IMMUNOLOGY

In Situ Vaccination with CD204 Gene-Silenced Dendritic Cell, not Unmodified Dendritic Cell, Enhances Radiation Therapy of Prostate Cancer

(2012) C. Guo et al.   MOLECULAR CANCER THERAPEUTICS

Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model

(2012) Reinhard Hinterleitner et al.   PLoS One

Current progress of siRNA/shRNA therapeutics in clinical trials

(2011) John C. Burnett et al.   Biotechnology Journal

Galectin-1 and -3 gene silencing in immature and mature dendritic cells enhances T cell activation and interferon-γ production

(2011) Anne Mobergslien et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Progress Toward In Vivo Use of siRNAs-II

(2011) Garrett R Rettig et al.   MOLECULAR THERAPY

Polymerase II Promoter Strength Determines Efficacy of microRNA Adapted shRNAs

(2011) Robert Jan Lebbink et al.   PLoS One

T Cell Treatment with Small Interfering RNA for Suppressor of Cytokine Signaling 3 Modulates Allergic Airway Responses in a Murine Model of Asthma

(2010) Atsushi Moriwaki et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Targeted Activation of RNA Helicase Retinoic Acid-Inducible Gene-I Induces Proimmunogenic Apoptosis of Human Ovarian Cancer Cells

(2010) K. Kubler et al.   CANCER RESEARCH

Designing Vaccines Based on Biology of Human Dendritic Cell Subsets

(2010) Karolina Palucka et al.   IMMUNITY

Origin and development of dendritic cells

(2010) Kang Liu et al.   IMMUNOLOGICAL REVIEWS

STAT3 Silencing in Dendritic Cells by siRNA Polyplexes Encapsulated in PLGA Nanoparticles for the Modulation of Anticancer Immune Response

(2010) Aws Alshamsan et al.   MOLECULAR PHARMACEUTICS

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

(2010) F. Stephen Hodi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Galectin-3 regulates T-cell functions

(2009) Daniel K. Hsu et al.   IMMUNOLOGICAL REVIEWS

Modulation of dendritic cell maturation and function with mono- and bifunctional small interfering RNAs targeting indoleamine 2,3-dioxygenase

(2009) Gro F. Flatekval et al.   IMMUNOLOGY

Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR–induced stop signal

(2009) Brian T Fife et al.   NATURE IMMUNOLOGY

In Situ Regulation of DC Subsets and T Cells Mediates Tumor Regression in Mice

(2009) O. A. Ali et al.   Science Translational Medicine

T Cell-Specific siRNA Delivery Suppresses HIV-1 Infection in Humanized Mice

(2008) Priti Kumar et al.   CELL

Silencing of endogenous IL-10 in human dendritic cells leads to the generation of an improved CTL response against human melanoma associated antigenic epitope, MART-127–35

(2008) Arvind Chhabra et al.   CLINICAL IMMUNOLOGY

siRNA stabilization prolongs gene knockdown in primary T lymphocytes

(2008) Andrej Mantei et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

5′-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma

(2008) Hendrik Poeck et al.   NATURE MEDICINE

CTLA-4 Control over Foxp3+ Regulatory T Cell Function

(2008) K. Wing et al.   SCIENCE