Leukemia cell-targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

(2013) Q. Zhang et al.   BLOOD

Cytokine profiles in acute myeloid leukemia patients at diagnosis: Survival is inversely correlated with IL-6 and directly correlated with IL-10 levels

(2013) Beatriz Sanchez-Correa et al.   CYTOKINE

CD40 ligation reverses T cell tolerance in acute myeloid leukemia

(2013) Long Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Intracellular processing of immunostimulatory CpG–siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape

(2013) Sergey Nechaev et al.   JOURNAL OF CONTROLLED RELEASE

Coinhibitory molecules in hematologic malignancies: targets for therapeutic intervention

(2012) W. J. Norde et al.   BLOOD

New generation small-molecule inhibitors in myeloproliferative neoplasms

(2012) Francesco Passamonti et al.   CURRENT OPINION IN HEMATOLOGY

Targeting the PD-1/B7-H1(PD-L1) pathway to activate anti-tumor immunity

(2012) Suzanne L Topalian et al.   CURRENT OPINION IN IMMUNOLOGY

Leukemia-associated antigens and their relevance to the immunotherapy of acute myeloid leukemia

(2012) S Anguille et al.   LEUKEMIA

Regulatory T cells in acute myelogenous leukemia: is it time for immunomodulation?

(2011) C. Ustun et al.   BLOOD

Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor

(2011) M. S. Redell et al.   BLOOD

Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

(2011) Q. Zhou et al.   BLOOD

Cancer Immunotherapy Comes of Age

(2011) Suzanne L. Topalian et al.   JOURNAL OF CLINICAL ONCOLOGY

The transcription factor PlagL2 activates Mpl transcription and signaling in hematopoietic progenitor and leukemia cells

(2011) S F Landrette et al.   LEUKEMIA

Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia

(2010) Q. Zhou et al.   BLOOD

In acute myeloid leukemia, B7-H1 (PD-L1) protection of blasts from cytotoxic T cells is induced by TLR ligands and interferon-gamma and can be reversed using MEK inhibitors

(2010) Céline Berthon et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Targeting Stat3 in the Myeloid Compartment Drastically Improves the In vivo Antitumor Functions of Adoptively Transferred T Cells

(2010) A. Herrmann et al.   CANCER RESEARCH

PD-L1 expression on tolerogenic APCs is controlled by STAT-3

(2010) Sabine J. Wölfle et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

STAT3-induced S1PR1 expression is crucial for persistent STAT3 activation in tumors

(2010) Heehyoung Lee et al.   NATURE MEDICINE

Expression of toll-like receptor-9 is increased in poorly differentiated prostate tumors

(2010) Marja-Riitta Väisänen et al.   PROSTATE

PD-1/PD-L1 interactions inhibit antitumor immune responses in a murine acute myeloid leukemia model

(2009) L. Zhang et al.   BLOOD

Toll-like Receptor 9 Activation of Signal Transducer and Activator of Transcription 3 Constrains Its Agonist-Based Immunotherapy

(2009) M. Kortylewski et al.   CANCER RESEARCH

Targeting Signal Transducer and Activator of Transcription Signaling Pathway in Leukemias

(2009) Mustafa Benekli et al.   JOURNAL OF CLINICAL ONCOLOGY

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

(2009) Marcin Kortylewski et al.   NATURE BIOTECHNOLOGY

STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells

(2008) P. A. Cohen et al.   BLOOD

STAT3 as a target for inducing apoptosis in solid and hematological tumors

(2008) Khandaker Al Zaid Siddiquee et al.   CELL RESEARCH

Obstacles to effective Toll-like receptor agonist therapy for hematologic malignancies

(2008) D E Spaner et al.   ONCOGENE

TLR signaling by tumor and immune cells: a double-edged sword

(2008) B Huang et al.   ONCOGENE

Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1)

(2008) M. Marzec et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The wolf in sheep's clothing: the role of interleukin-6 in immunity, inflammation and cancer

(2008) Willscott E. Naugler et al.   TRENDS IN MOLECULAR MEDICINE