Article
Cell Biology
Jie Wang, Ian Loveless, Indra Adrianto, Tingting Liu, Kalpana Subedi, Xiaojun Wu, Md Moazzem Hossain, Eric Sebzda, Li Zhou, Qing-Sheng Mi
Summary: This study found that iNKT cell subsets exhibit differences in various peripheral organs and have unique distributions, especially for iNKT1 cells. The research also revealed the important role of Klf2 in regulating the migration and differentiation of iNKT cells.
Article
Hematology
Madeleine L. Stimpson, Julia Wolf, Bruno Charbit, Emily L. Williams, Philippa J. P. Lait, Lauren P. Schewitz-Bowers, Richard W. J. Lee, Charlotte A. Bradbury
Summary: Regulatory B (Breg) cells play an important role in the pathogenesis of immune thrombocytopenia (ITP). The numbers of Bregs are significantly reduced in ITP patients treated with immunosuppression, and glucocorticoid treatment impairs Breg interleukin-10 production via an indirect T-cell-mediated mechanism.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Cell Biology
William Grey, Ana Rio-Machin, Pedro Casado, Eva Gronroos, Sara Ali, Juho J. Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A. Heckman, Charles Swanton, Pedro R. Cutillas, John Gribben, Jude Fitzgibbon, Dominique Bonnet
Summary: This study found that CKS1-dependent protein degradation plays a key role in eliminating tumor stem cells and reducing chemotherapeutic toxicity, while protecting normal hematopoietic stem cells in acute myeloid leukemia. These findings are of great significance for understanding the key vulnerability in malignant stem cell biology.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jiaoxiang Wu, Yue Wang, Shihao Bai, Hanxiao Sun, Jie Zhang, Jie Shu, Yajie Wang, Meiyu Tan, Lida Zhou, Biao Huang, Qiuhui Pan, Huiming Sheng
Summary: Although the roles of B lymphocyte subsets in the antitumor immune response are not determined, our study found that HCC patients have a higher frequency of B10 cells and a lower percentage of MZB cells compared to healthy controls. The changes in B cell subsets might occur at an early stage and the frequency of B10 cells decreased after surgery. The elevated IL-10 level in HCC serum may be a new biomarker in HCC identification. These findings suggest that altered B cell subsets are associated with the development and prognosis of HCC, and B cell subsets and related cytokines could be potential targets for immunotherapy in HCC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Imogen Morris, Cresci-Anne Croes, Marianne Boes, Eric Kalkhoven
Summary: Invariant natural killer T (iNKT) cells can be activated by binding antigenic lipid/CD1d complexes. Antigenic lipids are processed, loaded, and displayed by lipid antigen-presenting cells (LAPCs). Recent studies show that adipocytes, in addition to their role in lipid storage, can activate iNKT cells and play a role in metabolic disease. It is important to understand the parameters that determine cytokine output and how obesity-associated metabolic disease affects them.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2023)
Article
Biochemistry & Molecular Biology
Elizabeth A. Leadbetter, Mikael C. I. Karlsson
Summary: The interaction between iNKT cells and B cells plays a crucial role in regulating immune responses. iNKT cells can modulate inflammation and autoimmunity by interacting with B cell populations, offering potential new avenues for clinical interventions for relevant diseases.
MOLECULAR IMMUNOLOGY
(2021)
Article
Cell Biology
Joo-Young Park, Hee Yeun Won, Devon T. DiPalma, Hye Kyung Kim, Tae-Hyoun Kim, Can Li, Noriko Sato, Changwan Hong, Ninan Abraham, Ronald E. Gress, Jung-Hyun Park
Summary: This study investigates the cytokine requirement for in vivo iNKT cells and finds that IL-7, not IL-15, is the homeostatic cytokine for iNKT cells. The abundance of IL-7 limits the size of the peripheral iNKT cell pool and there is competition for IL-7 between iNKT and conventional ab T cells.
Article
Cell Biology
Mei-Chuan Chou, Hsiang-Chun Lee, Yen-Chin Liu, Patrick Szu-Ying Yen, Ching-Kuan Liu, Chu-Huang Chen, Tzu-Han Hsieh, Shiou-Lan Chen
Summary: This study found that long-term consumption of a high-fat diet may cause lipid metabolism overload in the brain and damage to glial cells. This may affect the protection of the brain and the survival of specific neurons.
Article
Clinical Neurology
Rosa Margareta Brand, Verena Friedrich, Jolien Diddens, Monika Pfaller, Francesca Romana de Franchis, Helena Radbruch, Bernhard Hemmer, Katja Steiger, Klaus Lehmann-Horn
Summary: The study found that in a model of CNS autoimmune disease, meningeal inflammatory infiltrates can form and persist even in the absence of B cells, suggesting that meningeal ectopic lymphoid tissue may have unknown capacities independent of B cells and contribute to CNS autoimmunity.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Biochemistry & Molecular Biology
Sabine Tacke, Rittika Chunder, Verena Schropp, Eduard Urich, Stefanie Kuerten
Summary: This study investigated the effects of a novel class of anti-CD20 monoclonal antibodies on B cells in an animal model of multiple sclerosis. The results showed that these antibodies can modulate the immune response and pathology of the central nervous system driven by B cells, with type II antibodies potentially being more effective in depleting tissue-infiltrating B cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Qiugang Zhu, Ke Rui, Shengjun Wang, Jie Tian
Summary: Recent research has shown that B cells, traditionally seen as effectors of the immune system, can also act as regulatory B cells (Bregs) with immunosuppressive functions. Bregs exert their effects through various mechanisms such as secretion of anti-inflammatory cytokines and direct cell contact. Maintaining a balance between Bregs and effector B cells is crucial for immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lei Zhu, Binyao Chen, Wenru Su
Summary: Non-infectious uveitis is an inflammatory eye disorder that can lead to severe visual loss. While T cells are known to be involved in the inflammation process, the role of B cells in uveitis pathogenesis is not well understood. Evidence suggests that B cells play diverse roles in different types of non-infectious uveitis, including producing autoantibodies, regulating T cell responses, and forming ectopic lymphoid structures. Regulatory B cells have anti-inflammatory functions in this disease, and rituximab may work by depleting pro-inflammatory B cells and restoring regulatory B cell function.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Hiroyuki Yoshitomi
Summary: This review summarizes the phenotype and function of peripheral helper T (Tph) cells and discusses their role in rheumatoid arthritis (RA) as well as their diversity in different diseases and immune development.
INTERNATIONAL IMMUNOLOGY
(2023)
Review
Immunology
Nardos Cheru, David A. Hafler, Tomokazu S. Sumida
Summary: Maintenance of peripheral tolerance by CD4(+)Foxp3(+) regulatory T cells is crucial for regulating autoreactive T cells. Dysfunction of Foxp3 leads to autoimmune diseases. Tregs not only maintain immune homeostasis, but also establish tissue microenvironment and homeostasis of non-lymphoid tissues. Tissue resident Tregs show unique profiles and interact with both immune and non-immune cells, exerting suppressive function and adopting to local microenvironment through bidirectional interactions.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Theresa Greiner, Markus Kipp
Summary: Multiple sclerosis initially presents with a relapsing-remitting disease course, then progresses to a secondary progressive stage. In both stages, peripheral immune cells are triggered by CNS-intrinsic stimuli to invade the brain parenchyma.
Article
Multidisciplinary Sciences
Shengli Xu, Xijun Ou, Jianxin Huo, Kristen Lim, Yuhan Huang, Sheena Chee, Kong-Peng Lam
NATURE COMMUNICATIONS
(2015)
Editorial Material
Oncology
Koon-Guan Lee, Kong-Peng Lam
Article
Cell Biology
Koon-Guan Lee, Susana Soo-Yeon Kim, Lin Kui, Dominic Chih-Cheng Voon, Marjorie Mauduit, Pradeep Bist, Xuezhi Bi, Natasha Ann Pereira, Chengcheng Liu, Bindu Sukumaran, Laurent Renia, Yoshiaki Ito, Kong-Peng Lam
Article
Biochemical Research Methods
Wan Ping Loh, Bernard Loo, Lihan Zhou, Peiqing Zhang, Dong-Yup Lee, Yuansheng Yang, Kong Peng Lam
BIOTECHNOLOGY JOURNAL
(2014)
Article
Immunology
Susana Soo-Yeon Kim, Koon-Guan Lee, Ching-Siang Chin, Say-Kong Ng, Natasha Ann Pereira, Shengli Xu, Kong-Peng Lam
JOURNAL OF IMMUNOLOGY
(2014)
Article
Multidisciplinary Sciences
Yan-Feng Li, Koon-Guan Lee, Xijun Ou, Kong-Peng Lam
Article
Multidisciplinary Sciences
Xijun Ou, Shengli Xu, Yan-Feng Li, Kong-Peng Lam
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Multidisciplinary Sciences
Yan-Feng Li, Shengli Xu, Xijun Ou, Kong-Peng Lam
NATURE COMMUNICATIONS
(2014)
Article
Multidisciplinary Sciences
Robin Graf, Jane Seagal, Kevin L. Otipoby Section, Kong-Peng Lam, Salah Ayoub, Baochun Zhang, Sandrine Sander, Van Trung Chu, Klaus Rajewsky
Article
Medicine, Research & Experimental
Jia Tong Loh, Shengli Xu, Jian Xin Huo, Susana Soo-Yeon Kim, Yue Wang, Kong-Peng Lam
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Cell Biology
Di Guan, Zixi Wang, Jianxin Huo, Shengli Xu, Kong-Peng Lam
Summary: Deficiency in BTK promotes IBD progression by increasing pro-inflammatory Th1 response, which is not caused by gut microbiota changes but by T cell-extrinsic and -intrinsic mechanisms.
CELL DEATH & DISEASE
(2021)
Article
Cell & Tissue Engineering
Jia Tong Loh, Bin Zhang, Joey Kay Hui Teo, Ruenn Chai Lai, Andre Boon Hwa Choo, Kong-Peng Lam, Sai Kiang Lim
Summary: This study identified a feed-forward loop between complements and neutrophils that contributes to the cytokine storm in severe SARS-CoV-2-infected patients. It was observed that the terminal complement activation complex C5b-9 directly triggers neutrophil extracellular trap (NET) release and interleukin (IL)-17 production by neutrophils. Mesenchymal stem cell (MSC) exosomes were found to inhibit this loop by suppressing complement activation through exosomal CD59, suggesting their potential role in alleviating immune dysregulation and inflammation in acute respiratory failure.
Article
Cell Biology
Jia Tong Loh, Koon-Guan Lee, Alison P. Lee, Joey Kay Hui Teo, Hsueh Lee Lim, Susana Soo-Yeon Kim, Andy Hee-Meng Tan, Kong-Peng Lam
Summary: DOK3, an adapter protein involved in immune signaling, plays a crucial role in maintaining gut microbial balance and colon homeostasis by suppressing JAK2/STAT3 signaling in colonic neutrophils, thereby protecting against inflammatory bowel disease.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Bin Zhang, Biyan Zhang, Ruenn Chai Lai, Wei Kian Sim, Kong Peng Lam, Sai Kiang Lim
Summary: Mesenchymal stem/stromal cell small extracellular vesicles (MSC-sEVs) have shown promise in treating various human diseases in animal models. However, the potential for contraindication in fibrotic diseases due to their ability to induce pro-fibrotic M2 macrophage polarization is an important consideration. Despite this, MSC-sEVs were found to be effective in reducing liver fibrosis in a mouse model of non-alcoholic steatohepatitis (NASH).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Shi Yong Neo, Shengli Xu, Joni Chong, Kong-Peng Lam, Jing Wu
Summary: Cell therapy is a growing field that involves the use of various types of immune cells, including T cells, for the treatment of human ailments such as cancer. This review focuses on cell therapy in the immuno-oncology space, discussing recent advances in different cell therapies and strategies to enhance therapeutic responses. Additionally, potential alternative immune cell types are explored to overcome the limitations of conventional adoptive cell therapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)