Journal
MOLECULAR IMMUNOLOGY
Volume 130, Issue -, Pages 49-54Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2020.12.005
Keywords
invariant Natural Killer T cells (iNKT); B-reg cells; Marginal zone B cells; Humoral immunity; iNKT; (FH)iNKT(reg)
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Funding
- National Institute of Allergy and Infectious Diseases [R01AI132798]
- Hesselman foundation
- Gustav V's 80 year foundation
- Swedish Research Council
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The interaction between iNKT cells and B cells plays a crucial role in regulating immune responses. iNKT cells can modulate inflammation and autoimmunity by interacting with B cell populations, offering potential new avenues for clinical interventions for relevant diseases.
Rapid immune responses regulated by invariant Natural Killer T (iNKT) cells bridge the gap between innate and adaptive responses to pathogens, while also providing key regulation to maintain immune homeostasis. iNKT immune protection and immune regulation are both mediated through interactions with innate and adaptive B cell populations that express CD1d. Recent studies have expanded our understanding of the position of iNKT cells at the fulcrum between regulating inflammatory and autoreactive B cells. Environmental signals influence iNKT cells to set the tone for subsequent adaptive responses, ranging from maintaining homeostasis as an iNKT regulatory cell (iNKT(reg)) or supporting pathogen-specific effector B cells as an iNKT follicular helper (iNKT(FH)). Here we review recent advances in iNKT and B cell cooperation during autoimmunity and sterile inflammation. Understanding the nature of the interactions between iNKT and B cells will enable the development of clinical interventions to strategically target regulatory iNKT and B cell populations or inflammatory ones, across a range of indications.
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