Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels

De Novo Mutations in NALCN Cause a Syndrome Characterized by Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay

(2015) Jessica X. Chong et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Evolution of voltage-gated ion channels at the emergence of Metazoa

(2015) Y. Moran et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Bacterial Voltage-Gated Sodium Channels (BacNaVs) from the Soil, Sea, and Salt Lakes Enlighten Molecular Mechanisms of Electrical Signaling and Pharmacology in the Brain and Heart

(2015) Jian Payandeh et al.   JOURNAL OF MOLECULAR BIOLOGY

The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

(2015) Shangbang Gao et al.   Nature Communications

Single particle electron cryo-microscopy of a mammalian ion channel

(2014) Maofu Liao et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

T-type Channels Become Highly Permeable to Sodium Ions Using an Alternative Extracellular Turret Region (S5-P) Outside the Selectivity Filter

(2014) Adriano Senatore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Folding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4

(2014) Viacheslav S. Korkosh et al.   JOURNAL OF GENERAL PHYSIOLOGY

Sodium channel selectivity and conduction: Prokaryotes have devised their own molecular strategy

(2014) Rocio K. Finol-Urdaneta et al.   JOURNAL OF GENERAL PHYSIOLOGY

Cav3 T-type channels: regulators for gating, membrane expression, and cation selectivity

(2014) A. Senatore et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Gd3+ and Calcium Sensitive, Sodium Leak Currents Are Features of Weak Membrane-Glass Seals in Patch Clamp Recordings

(2014) Adrienne N. Boone et al.   PLoS One

Evolutionarily conserved intracellular gate of voltage-dependent sodium channels

(2014) Kevin Oelstrom et al.   Nature Communications

Block of T-type calcium channels by protoxins I and II

(2014) Chris Bladen et al.   Molecular Brain

Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus

(2014) Paul G DeCaen et al.   eLife

Asp residues of the Glu-Glu-Asp-Asp pore filter contribute to ion permeation and selectivity of the Cav3.2 T-type channel

(2013) Hyun-Jee Park et al.   CELL CALCIUM

Structure and function of voltage-gated sodium channels at atomic resolution

(2013) William A. Catterall   EXPERIMENTAL PHYSIOLOGY

Two Alternative Conformations of a Voltage-Gated Sodium Channel

(2013) Ching-Ju Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of a Prokaryotic Sodium Channel Pore Reveals Essential Gating Elements and an Outer Ion Binding Site Common to Eukaryotic Channels

(2013) David Shaya et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Structural basis for Ca2+ selectivity of a voltage-gated calcium channel

(2013) Lin Tang et al.   NATURE

NALCN Ion Channels Have Alternative Selectivity Filters Resembling Calcium Channels or Sodium Channels

(2013) Adriano Senatore et al.   PLoS One

UNC79 and UNC80, Putative Auxiliary Subunits of the NARROW ABDOMEN Ion Channel, Are Indispensable for Robust Circadian Locomotor Rhythms in Drosophila

(2013) Bridget C. Lear et al.   PLoS One

Catalysis of Na+ permeation in the bacterial sodium channel NaVAb

(2013) N. Chakrabarti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ancient Origin of Four-Domain Voltage-gated Na+ Channels Predates the Divergence of Animals and Fungi

(2012) Xinjiang Cai   JOURNAL OF MEMBRANE BIOLOGY

Voltage-gated potassium channels and the diversity of electrical signalling

(2012) Lily Yeh Jan et al.   JOURNAL OF PHYSIOLOGY-LONDON

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel

(2012) Xu Zhang et al.   NATURE

hERG K+ Channels: Structure, Function, and Clinical Significance

(2012) Jamie I. Vandenberg et al.   PHYSIOLOGICAL REVIEWS

Gene Transcription and Splicing of T-Type Channels Are Evolutionarily-Conserved Strategies for Regulating Channel Expression and Gating

(2012) Adriano Senatore et al.   PLoS One

Adaptive evolution of voltage-gated sodium channels: The first 800 million years

(2012) H. H. Zakon   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constraint shapes convergence in tetrodotoxin-resistant sodium channels of snakes

(2012) C. R. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human K2P TRAAK, a Lipid- and Mechano-Sensitive K+ Ion Channel

(2012) S. G. Brohawn et al.   SCIENCE

Crystal Structure of the Human Two-Pore Domain Potassium Channel K2P1

(2012) A. N. Miller et al.   SCIENCE

T-Type Calcium Channel Blockers That Attenuate Thalamic Burst Firing and Suppress Absence Seizures

(2012) E. Tringham et al.   Science Translational Medicine

Structure of a bacterial voltage-gated sodium channel pore reveals mechanisms of opening and closing

(2012) Emily C. McCusker et al.   Nature Communications

Convergent Evolution of Sodium Ion Selectivity in Metazoan Neuronal Signaling

(2012) Maya Gur Barzilai et al.   Cell Reports

NaChBac: The Long Lost Sodium Channel Ancestor

(2011) Kalypso Charalambous et al.   BIOCHEMISTRY

Simplified Bacterial “Pore” Channel Provides Insight into the Assembly, Stability, and Structure of Sodium Channels

(2011) Emily C. McCusker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The crystal structure of a voltage-gated sodium channel

(2011) Jian Payandeh et al.   NATURE

Evolution of sodium channels predates the origin of nervous systems in animals

(2011) B. J. Liebeskind et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Labelling of the 3D structure of the cardiac L-type voltage-gated calcium channel

(2010) Conor P. Walsh et al.   Channels

T-type calcium channels inhibitors: a patent review

(2010) Fabrizio Giordanetto et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Possible Roles of Exceptionally Conserved Residues around the Selectivity Filters of Sodium and Calcium Channels

(2010) Denis B. Tikhonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient and Big Are Key Features of an Invertebrate T-type Channel (LCav3) from the Central Nervous System ofLymnaea stagnalis

(2010) Adriano Senatore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective T-Type Calcium Channel Block in Thalamic Neurons Reveals Channel Redundancy and Physiological Impact of ITwindow

(2010) F. M. Dreyfus et al.   JOURNAL OF NEUROSCIENCE

Ion Channel Voltage Sensors: Structure, Function, and Pathophysiology

(2010) William A. Catterall   NEURON

Cysteines in the loop between IS5 and the pore helix of CaV3.1 are essential for channel gating

(2010) Maria Karmazinova et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Determinants of voltage-gated sodium channel clustering in neurons

(2010) Christophe Leterrier et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The NALCN ion channel is activated by M3 muscarinic receptors in a pancreatic β-cell line

(2009) Leigh Anne Swayne et al.   EMBO REPORTS

Functional Expression of an Arachnid Sodium Channel Reveals Residues Responsible for Tetrodotoxin Resistance in Invertebrate Sodium Channels

(2009) Yuzhe Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three-dimensional Structure of CaV3.1

(2009) Conor P. Walsh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Eukaryotic Strong Inward-Rectifier K+ Channel Kir2.2 at 3.1 A Resolution

(2009) X. Tao et al.   SCIENCE

Toxin-Resistant Sodium Channels: Parallel Adaptive Evolution across a Complete Gene Family

(2008) M. C. Jost et al.   MOLECULAR BIOLOGY AND EVOLUTION