From Cholesterogenesis to Steroidogenesis: Role of Riboflavin and Flavoenzymes in the Biosynthesis of Vitamin D

Extrarenal Vitamin D Activation and Interactions Between Vitamin D2, Vitamin D3, and Vitamin D Analogs

(2013) Glenville Jones   Annual Review of Nutrition

Biosynthesis of Flavin Cofactors in Man: Implications in Health and Disease

(2013) Maria Barile et al.   CURRENT PHARMACEUTICAL DESIGN

Cytochromes P450: Roles in Diseases

(2013) Irina A. Pikuleva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CYP2R1 is a major, but not exclusive, contributor to 25-hydroxyvitamin D production in vivo

(2013) J. G. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Links between copper and cholesterol in Alzheimer's disease

(2013) Ya Hui Hung et al.   Frontiers in Physiology

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

(2012) Laura Tripkovic et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?

(2012) Jinge Zhu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

NADPH–cytochrome P450 oxidoreductase: Prototypic member of the diflavin reductase family

(2012) Takashi Iyanagi et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Effects of the lipid environment, cholesterol and bile acids on the function of the purified and reconstituted human ABCG2 protein

(2012) Ágnes Telbisz et al.   BIOCHEMICAL JOURNAL

Exome sequencing reveals riboflavin transporter mutations as a cause of motor neuron disease

(2012) Janel O. Johnson et al.   BRAIN

Molecular mechanisms of riboflavin responsiveness in patients with ETF-QO variations and multiple acyl-CoA dehydrogenation deficiency

(2012) N. Cornelius et al.   HUMAN MOLECULAR GENETICS

Low Serum 25-Hydroxyvitamin D Is Associated with Increased Risk of the Development of the Metabolic Syndrome at Five Years: Results from a National, Population-Based Prospective Study (The Australian Diabetes, Obesity and Lifestyle Study: AusDiab)

(2012) Claudia Gagnon et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Sterols in spermatogenesis and sperm maturation

(2012) Rok Keber et al.   JOURNAL OF LIPID RESEARCH

Fortified Malted Milk Drinks Containing Low-Dose Ergocalciferol and Cholecalciferol Do Not Differ in Their Capacity to Raise Serum 25-Hydroxyvitamin D Concentrations in Healthy Men and Women Not Exposed to UV-B

(2012) Catherine M. Fisk et al.   JOURNAL OF NUTRITION

Mitochondrial complex I deficiency and ATP/ADP ratio in lymphocytes of amyotrophic lateral sclerosis patients

(2012) Parisa Ghiasi et al.   NEUROLOGICAL RESEARCH

Mapping of Gene Expression Reveals CYP27A1 as a Susceptibility Gene for Sporadic ALS

(2012) Frank P. Diekstra et al.   PLoS One

Mitochondrial Localization of ABC Transporter ABCG2 and Its Function in 5-Aminolevulinic Acid-Mediated Protoporphyrin IX Accumulation

(2012) Hirotsugu Kobuchi et al.   PLoS One

Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature

(2011) Christian P. Schaaf et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Structure, Mechanism, and Evolution of Ero1 Family Enzymes

(2011) Kazutaka Araki et al.   ANTIOXIDANTS & REDOX SIGNALING

Role of the interface between the FMN and FAD domains in the control of redox potential and electronic transfer of NADPH–cytochrome P450 reductase

(2011) Louise Aigrain et al.   BIOCHEMICAL JOURNAL

The human geneSLC25A17encodes a peroxisomal transporter of coenzyme A, FAD and NAD+

(2011) Gennaro Agrimi et al.   BIOCHEMICAL JOURNAL

Squalene monooxygenase – a target for hypercholesterolemic therapy

(2011) Agnieszka Belter et al.   BIOLOGICAL CHEMISTRY

Cholesterol-Dependent Degradation of Squalene Monooxygenase, a Control Point in Cholesterol Synthesis beyond HMG-CoA Reductase

(2011) Saloni Gill et al.   Cell Metabolism

Regulation of Hepatic Cytochromes P450 by Lipids and Cholesterol

(2011) Mateja Hafner et al.   CURRENT DRUG METABOLISM

The desmosterolosis phenotype: spasticity, microcephaly and micrognathia with agenesis of corpus callosum and loss of white matter

(2011) Jenny Zolotushko et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Smith–Lemli–Opitz syndrome

(2011) Andrea E. DeBarber et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Flavogenomics - a genomic and structural view of flavin-dependent proteins

(2011) Peter Macheroux et al.   FEBS Journal

Mouse Knockout of the Cholesterogenic Cytochrome P450 Lanosterol 14α-Demethylase (Cyp51) Resembles Antley-Bixler Syndrome

(2011) Rok Keber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D Deficiency, Adiposity, and Cardiometabolic Risk in Urban Schoolchildren

(2011) Jennifer Sacheck et al.   JOURNAL OF PEDIATRICS

7-Dehydrocholesterol reductase activity is independent of cytochrome P450 reductase

(2011) Ling Zou et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Role of a Disordered Steroid Metabolome in the Elucidation of Sterol and Steroid Biosynthesis

(2011) Cedric H. L. Shackleton   LIPIDS

Vitamin D metabolism and function in the skin

(2011) Daniel D. Bikle   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Prevalence and correlates of vitamin D deficiency in US adults

(2011) Kimberly Y.Z. Forrest et al.   NUTRITION RESEARCH

Structural basis for human NADPH-cytochrome P450 oxidoreductase deficiency

(2011) C. Xia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinguishing two groups of flavin reductases by analyzing the protonation state of an active site carboxylic acid

(2011) Verónica I. Dumit et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Structural Basis for the Disulfide Relay System in the Mitochondrial Intermembrane Space

(2010) Toshiya Endo et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial Respiratory Chain Dysfunction in Muscle From Patients With Amyotrophic Lateral Sclerosis

(2010) Veronica Crugnola et al.   ARCHIVES OF NEUROLOGY

Oxidation-driven protein import into mitochondria: Insights and blind spots

(2010) Jan Riemer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Emerging Roles for Riboflavin in Functional Rescue of Mitochondrial β-Oxidation Flavoenzymes

(2010) Barbara J. Henriques et al.   CURRENT MEDICINAL CHEMISTRY

Glucose regulates enzymatic sources of mitochondrial NADPH in skeletal muscle cells; a novel role for glucose-6-phosphate dehydrogenase

(2010) Ryan J. Mailloux et al.   FASEB JOURNAL

Diverse associations of 25-hydroxyvitamin D and 1,25-dihydroxy-vitamin D with dyslipidaemias

(2010) P. Karhapää et al.   JOURNAL OF INTERNAL MEDICINE

Origin of 7-Dehydrocholesterol (Provitamin D) in the Skin

(2010) Hartmut H. Glossmann   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Malformation syndromes caused by disorders of cholesterol synthesis

(2010) Forbes D. Porter et al.   JOURNAL OF LIPID RESEARCH

ABCG2 reduces ROS-mediated toxicity and inflammation: a potential role in Alzheimer’s disease

(2010) Shanshan Shen et al.   JOURNAL OF NEUROCHEMISTRY

Mitochondrial localization of human FAD synthetase isoform 1

(2010) Enza Maria Torchetti et al.   MITOCHONDRION

Perspectives of the non-statin hypolipidemic agents

(2010) Damjana Rozman et al.   PHARMACOLOGY & THERAPEUTICS

Erythrocyte pyridoxamine phosphate oxidase activity: a potential biomarker of riboflavin status?

(2009) Sohail Mushtaq et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Flavin-containing heme enzymes

(2009) Christopher G. Mowat et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Riboflavin concentration within ABCG2-rich extracellular vesicles is a novel marker for multidrug resistance in malignant cells

(2009) Ilan Ifergan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

RNA-Interference Approach to Study Functions of NADPH : Cytochrome P450 Oxidoreductase in Human Hepatocytes

(2009) Diana M. Feidt et al.   CHEMISTRY & BIODIVERSITY

Structure and Function of an NADPH-Cytochrome P450 Oxidoreductase in an Open Conformation Capable of Reducing Cytochrome P450

(2009) Djemel Hamdane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis for the Mechanism of Respiratory Complex I

(2009) John M. Berrisford et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vitamin D Production after UVB Exposure Depends on Baseline Vitamin D and Total Cholesterol but Not on Skin Pigmentation

(2009) Morten K.B. Bogh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Specific electron transport chain abnormalities in amyotrophic lateral sclerosis

(2009) Jerry Lin et al.   JOURNAL OF NEUROLOGY

Prevalence and Associations of 25-Hydroxyvitamin D Deficiency in US Children: NHANES 2001-2004

(2009) J. Kumar et al.   PEDIATRICS

Impairment of human CYP1A2-mediated xenobiotic metabolism by Antley–Bixler syndrome variants of cytochrome P450 oxidoreductase

(2008) Michel Kranendonk et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Impeded Electron Transfer From a Pathogenic FMN Domain Mutant of Methionine Synthase Reductase and Its Responsiveness to Flavin Supplementation†

(2008) Carmen G. Gherasim et al.   BIOCHEMISTRY

Interplay of Unsaturated Phospholipids and Cholesterol in Membranes: Effect of the Double-Bond Position

(2008) Hector Martinez-Seara et al.   BIOPHYSICAL JOURNAL

Neuroprotective effects of the Alzheimer's disease-related gene seladin-1

(2008) Alessandro Peri et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Ultrafast Dynamics of Flavins in Five Redox States

(2008) Ya-Ting Kao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid rafts, cholesterol, and the brain

(2008) Zeljka Korade et al.   NEUROPHARMACOLOGY

Molecular structure and regulation of phototropin kinase by blue light

(2007) Satoru Tokutomi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS