Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Inhibition of TBK1/IKKε Promotes Regeneration of Pancreatic β-cells
Authors
Keywords
-
Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-10-16
DOI
10.1038/s41598-018-33875-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue
- (2018) Peng Zhao et al. CELL
- Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration
- (2016) Kristie I. Aamodt et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- SerpinB1 Promotes Pancreatic β Cell Proliferation
- (2016) Abdelfattah El Ouaamari et al. Cell Metabolism
- An insulin signaling feedback loop regulates pancreas progenitor cell differentiation during islet development and regeneration
- (2016) Lihua Ye et al. DEVELOPMENTAL BIOLOGY
- Inhibition of DYRK1A Stimulates Human β-Cell Proliferation
- (2016) Ercument Dirice et al. DIABETES
- Activation of mTORC1 is essential for β-adrenergic stimulation of adipose browning
- (2016) Dianxin Liu et al. JOURNAL OF CLINICAL INVESTIGATION
- Four and a Half LIM Domains 1b (Fhl1b) Is Essential for Regulating the Liver versus Pancreas Fate Decision and for β-Cell Regeneration
- (2016) Jin Xu et al. PLoS Genetics
- Osteoprotegerin and Denosumab Stimulate Human Beta Cell Proliferation through Inhibition of the Receptor Activator of NF-κB Ligand Pathway
- (2015) Nagesha Guthalu Kondegowda et al. Cell Metabolism
- glucagon is essential for alpha cell transdifferentiation and beta cell neogenesis
- (2015) L. Ye et al. DEVELOPMENT
- WS6 induces both alpha and beta cell proliferation without affecting differentiation or viability
- (2015) Brian P. Boerner et al. ENDOCRINE JOURNAL
- A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication
- (2015) Peng Wang et al. NATURE MEDICINE
- Combination immunotherapies for type 1 diabetes mellitus
- (2015) Paolo Pozzilli et al. Nature Reviews Endocrinology
- Diabetes mellitus—advances and challenges in human β-cell proliferation
- (2015) Peng Wang et al. Nature Reviews Endocrinology
- Inhibition of DYRK1A and GSK3B induces human β-cell proliferation
- (2015) Weijun Shen et al. Nature Communications
- A subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis
- (2015) Shannon M. Reilly et al. Nature Communications
- Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes
- (2014) Nathalie Esser et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Antagonistic interaction between Wnt and Notch activity modulates the regenerative capacity of a zebrafish fibrotic liver model
- (2014) Mianbo Huang et al. HEPATOLOGY
- The role of metallothionein-3 in streptozotocin-induced beta-islet cell death and diabetes in mice
- (2014) Hyae-Ran Byun et al. Metallomics
- Targeting TBK1 Inhibits Migration and Resistance to MEK Inhibitors in Mutant NRAS Melanoma
- (2014) Ha Linh Vu et al. MOLECULAR CANCER RESEARCH
- Repurposing cAMP-Modulating Medications to Promote β-Cell Replication
- (2014) Zhenshan Zhao et al. MOLECULAR ENDOCRINOLOGY
- PI3 kinase directly phosphorylates Akt1/2 at Ser473/474 in the insulin signal transduction pathway
- (2013) A Tsuchiya et al. JOURNAL OF ENDOCRINOLOGY
- Small-Molecule Inducer of β Cell Proliferation Identified by High-Throughput Screening
- (2013) Weijun Shen et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
- (2013) Luc Baeyens et al. NATURE BIOTECHNOLOGY
- An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
- (2013) Shannon M Reilly et al. NATURE MEDICINE
- Islet inflammation: a unifying target for diabetes treatment?
- (2013) Yumi Imai et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1
- (2013) Jonathan Mowers et al. eLife
- Discovery of azabenzimidazole derivatives as potent, selective inhibitors of TBK1/IKKε kinases
- (2012) Tao Wang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Adenosine Signaling Promotes Regeneration of Pancreatic β Cells In Vivo
- (2012) Olov Andersson et al. Cell Metabolism
- Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
- (2012) Jessica E. Hutti et al. PLoS One
- Adenosine kinase inhibition selectively promotes rodent and porcine islet -cell replication
- (2012) J. P. Annes et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation
- (2012) X. Ma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The TRAF-associated protein TANK facilitates cross-talk within the I B kinase family during Toll-like receptor signaling
- (2011) K. Clark et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
- (2011) P. P. Hsu et al. SCIENCE
- Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss
- (2010) Fabrizio Thorel et al. NATURE
- The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice
- (2009) Shian-Huey Chiang et al. CELL
- Identification of small-molecule inducers of pancreatic -cell expansion
- (2009) W. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- β Cells Can Be Generated from Endogenous Progenitors in Injured Adult Mouse Pancreas
- (2008) Xiaobo Xu et al. CELL
- The IKK-related kinases: from innate immunity to oncogenesis
- (2008) Jean-François Clément et al. CELL RESEARCH
- -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of -Cell Mass in Humans
- (2008) J. J. Meier et al. DIABETES
- Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?
- (2008) Tieu-Lan Chau et al. TRENDS IN BIOCHEMICAL SCIENCES
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationPublish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn More