Fisetin targets YB-1/RSK axis independent of its effect on ERK signaling: insights from in vitro and in vivo melanoma models

p90RSK Blockade Inhibits Dual BRAF and MEK Inhibitor-Resistant Melanoma by Targeting Protein Synthesis

(2017) Nicholas Theodosakis et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

State of the science on prevention and screening to reduce melanoma incidence and mortality: The time is now

(2016) Mary K. Tripp et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Inhibiting Drivers of Non-mutational Drug Tolerance Is a Salvage Strategy for Targeted Melanoma Therapy

(2016) Michael P. Smith et al.   CANCER CELL

RSK-mediated nuclear accumulation of the cold-shock Y-box protein-1 controls proliferation of T cells and T-ALL blasts

(2016) Steffi Gieseler-Halbach et al.   CELL DEATH AND DIFFERENTIATION

Exploring the molecular targets of dietary flavonoid fisetin in cancer

(2016) Deeba N. Syed et al.   SEMINARS IN CANCER BIOLOGY

RSK1 protects P-glycoprotein/ABCB1 against ubiquitin–proteasomal degradation by downregulating the ubiquitin-conjugating enzyme E2 R1

(2016) Kazuhiro Katayama et al.   Scientific Reports

Fisetin, a phytochemical, potentiates sorafenib-induced apoptosis and abrogates tumor growth in athymic nude mice implanted with BRAF-mutated melanoma cells

(2015) Harish Chandra Pal et al.   Oncotarget

Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma

(2015) Harish C. Pal et al.   Oncotarget

Selectivity by Small-Molecule Inhibitors of Protein Interactions Can Be Driven by Protein Surface Fluctuations

(2015) David K. Johnson et al.   PLoS Computational Biology

YB-1 expression promotes epithelial-to-mesenchymal transition in prostate cancer that is inhibited by a small molecule fisetin

(2015) Mohammad Imran Khan et al.   Oncotarget

Involvement of ER stress and activation of apoptotic pathways in fisetin induced cytotoxicity in human melanoma

(2014) Deeba N. Syed et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fisetin inhibits human melanoma cell growth through direct binding to p70S6K and mTOR: Findings from 3-D melanoma skin equivalents and computational modeling

(2014) Deeba N. Syed et al.   BIOCHEMICAL PHARMACOLOGY

Inhibition of Akt/mTOR Signaling by the Dietary Flavonoid Fisetin

(2013) Deeba Syed et al.   Anti-Cancer Agents in Medicinal Chemistry

YB-1: oncoprotein, prognostic marker and therapeutic target?

(2013) Annette Lasham et al.   BIOCHEMICAL JOURNAL

P-glycoprotein associates with Anxa2 and promotes invasion in multidrug resistant breast cancer cells

(2013) Fei Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Antitumor effects of BI-D1870 on human oral squamous cell carcinoma

(2013) Chang-Fang Chiu et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

RSK Isoforms in Cancer Cell Invasion and Metastasis

(2013) F. J. Sulzmaier et al.   CANCER RESEARCH

Compound promiscuity: what can we learn from current data?

(2013) Ye Hu et al.   DRUG DISCOVERY TODAY

Y-box-binding protein 1 (YB-1) and its functions

(2012) I. A. Eliseeva et al.   BIOCHEMISTRY-MOSCOW

RSK2 as a key regulator in human skin cancer

(2012) Yong-Yeon Cho et al.   CARCINOGENESIS

MAPK and PI3K/AKT mediated YB-1 activation promotes melanoma cell proliferation which is counteracted by an autoregulatory loop

(2012) Tobias Sinnberg et al.   EXPERIMENTAL DERMATOLOGY

Regulation and function of the RSK family of protein kinases

(2011) Yves Romeo et al.   BIOCHEMICAL JOURNAL

Upregulation of mdr1 gene is related to activation of the MAPK/ERK signal transduction pathway and YB-1 nuclear translocation in B-cell lymphoma

(2011) Huiling Shen et al.   EXPERIMENTAL HEMATOLOGY

Inhibition of Human Melanoma Cell Growth by the Dietary Flavonoid Fisetin Is Associated with Disruption of Wnt/β-Catenin Signaling and Decreased Mitf Levels

(2011) Deeba N. Syed et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Nitric oxide promotes nicotine-triggered ERK signaling via redox reactions in PC12 cells

(2011) Yoshiaki Miyamoto et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease

(2010) Pamela Maher et al.   HUMAN MOLECULAR GENETICS

Molecular Decoy to the Y-Box Binding Protein-1 Suppresses the Growth of Breast and Prostate Cancer Cells whilst Sparing Normal Cell Viability

(2010) Jennifer H. Law et al.   PLoS One

Translational Activation of Snail1 and Other Developmentally Regulated Transcription Factors by YB-1 Promotes an Epithelial-Mesenchymal Transition

(2009) Valentina Evdokimova et al.   CANCER CELL

RSK Is a Principal Effector of the RAS-ERK Pathway for Eliciting a Coordinate Promotile/Invasive Gene Program and Phenotype in Epithelial Cells

(2009) Ulrik Doehn et al.   MOLECULAR CELL

The RSK family of kinases: emerging roles in cellular signalling

(2008) Rana Anjum et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY