KH176 under development for rare mitochondrial disease: a first in man randomized controlled clinical trial in healthy male volunteers

Therapeutic effects of the mitochondrial ROS-redox modulator KH176 in a mammalian model of Leigh Disease

(2017) Ria de Haas et al.   Scientific Reports

Toward a therapy for mitochondrial disease

(2016) Carlo Viscomi   BIOCHEMICAL SOCIETY TRANSACTIONS

Mitochondrial disorders in children: toward development of small-molecule treatment strategies

(2016) W. J. Koopman et al.   EMBO Molecular Medicine

Mitochondrial diseases

(2016) Gráinne S. Gorman et al.   Nature Reviews Disease Primers

Prevalence of nuclear and mitochondrial DNA mutations related to adult mitochondrial disease

(2015) Gráinne S. Gorman et al.   ANNALS OF NEUROLOGY

MitoCarta2.0: an updated inventory of mammalian mitochondrial proteins

(2015) Sarah E. Calvo et al.   NUCLEIC ACIDS RESEARCH

Differentiating Drug-Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil

(2014) L Johannesen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

A new LC–MS/MS method for the clinical determination of reduced and oxidized glutathione from whole blood

(2013) Tereza Moore et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Drug induced QT prolongation: the measurement and assessment of the QT interval in clinical practice

(2012) Geoffrey K. Isbister et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases

(2012) S. Koene et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Monogenic Mitochondrial Disorders

(2012) Werner J.H. Koopman et al.   NEW ENGLAND JOURNAL OF MEDICINE

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

(2011) Thomas Klopstock et al.   BRAIN

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Prevention of Torsade de Pointes in Hospital Settings

(2010) Barbara J. Drew et al.   CIRCULATION

A randomized trial of coenzyme Q10in mitochondrial disorders

(2010) Elisa I. Glover et al.   MUSCLE & NERVE

Phospholipidosis in healthy subjects participating in clinical studies: Ultrastructural findings in white blood cells

(2009) Andreas Pospischil et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Inherited disorders affecting mitochondrial function are associated with glutathione deficiency and hypocitrullinemia

(2009) K. R. Atkuri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Automatic analysis of cardiac repolarization morphology using Gaussian mesa function modeling

(2008) Fabio Badilini et al.   JOURNAL OF ELECTROCARDIOLOGY