The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo

SRC is a signaling mediator in FLT3-ITD- but not in FLT3-TKD-positive AML

(2012) H. Leischner et al.   BLOOD

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

(2011) H. H. Zhu et al.   BLOOD

Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia

(2011) B. Mizukawa et al.   BLOOD

A critical role for SHP2 in STAT5 activation and growth factor-mediated proliferation, survival, and differentiation of human CD34+ cells

(2011) L. Li et al.   BLOOD

Essential role for Ptpn11 in survival of hematopoietic stem and progenitor cells

(2011) G. Chan et al.   BLOOD

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Bench to Bedside Targeting of FLT3 in Acute Leukemia

(2010) Keith W. Pratz et al.   CURRENT DRUG TARGETS

Salicylic Acid Based Small Molecule Inhibitor for the Oncogenic Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (SHP2)

(2010) Xian Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

(2009) Kristina Masson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Negative Regulation of Stat3 by ActivatingPTPN11Mutants Contributes to the Pathogenesis of Noonan Syndrome and Juvenile Myelomonocytic Leukemia

(2009) Wenjun Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants

(2009) Z. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family

(2009) L J Beverly et al.   ONCOGENE

Role of SHP2 for FLT3-dependent proliferation and transformation in 32D cells

(2008) J P Müller et al.   LEUKEMIA