The GBAP1 pseudogene acts as a ceRNA for the glucocerebrosidase gene GBA by sponging miR-22-3p

Survival and dementia inGBA-associated Parkinson's disease: The mutation matters

(2016) Roberto Cilia et al.   ANNALS OF NEUROLOGY

Leveraging Rules of Nonsense-Mediated mRNA Decay for Genome Engineering and Personalized Medicine

(2016) Maximilian W. Popp et al.   CELL

Endogenous microRNA sponges: evidence and controversy

(2016) Daniel W. Thomson et al.   NATURE REVIEWS GENETICS

Glucocerebrosidase activity in Parkinson’s disease with and withoutGBAmutations

(2015) Roy N. Alcalay et al.   BRAIN

The 3′UTR of the pseudogene CYP4Z2P promotes tumor angiogenesis in breast cancer by acting as a ceRNA for CYP4Z1

(2015) Lufeng Zheng et al.   BREAST CANCER RESEARCH AND TREATMENT

The BRAF Pseudogene Functions as a Competitive Endogenous RNA and Induces Lymphoma In Vivo

(2015) Florian A. Karreth et al.   CELL

miRWalk2.0: a comprehensive atlas of microRNA-target interactions

(2015) Harsh Dweep et al.   NATURE METHODS

MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma

(2015) SHOULIN ZHANG et al.   ONCOLOGY REPORTS

Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

(2015) Zhe Ji et al.   eLife

Identification of miRNAs that modulate glucocerebrosidase activity in Gaucher disease cells

(2015) Marina Siebert et al.   RNA Biology

MicroRNA-22 Induces Endothelial Progenitor Cell Senescence by Targeting AKT3

(2014) Yue Zheng et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis

(2014) E. M. Paraboschi et al.   HUMAN MOLECULAR GENETICS

Neuroprotective Effects of Viral Overexpression of microRNA-22 in Rat and Cell Models of Cerebral Ischemia-Reperfusion Injury

(2014) Houyou Yu et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The multilayered complexity of ceRNA crosstalk and competition

(2014) Yvonne Tay et al.   NATURE

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease

(2014) Mike A Nalls et al.   NATURE GENETICS

lncRNAdb v2.0: expanding the reference database for functional long noncoding RNAs

(2014) Xiu Cheng Quek et al.   NUCLEIC ACIDS RESEARCH

Glucocerebrosidase mutations in primary parkinsonism

(2014) Rosanna Asselta et al.   PARKINSONISM & RELATED DISORDERS

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

(2014) Eun-Jin Bae et al.   Nature Communications

Organizing Principles of Mammalian Nonsense-Mediated mRNA Decay

(2013) Maximilian Wei-Lin Popp et al.   Annual Review of Genetics

Pseudogene OCT4-pg4 functions as a natural micro RNA sponge to regulate OCT4 expression by competing for miR-145 in hepatocellular carcinoma

(2013) Lei Wang et al.   CARCINOGENESIS

MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress

(2013) Zhan-Peng Huang et al.   CIRCULATION RESEARCH

miRBase: annotating high confidence microRNAs using deep sequencing data

(2013) Ana Kozomara et al.   NUCLEIC ACIDS RESEARCH

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington’s Disease-Related Mechanisms

(2013) Ana Jovicic et al.   PLoS One

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

(2012) Virginija Jazbutyte et al.   AGE

Glucocerebrosidase deficiency in substantia nigra of parkinson disease brains

(2012) Matthew E. Gegg et al.   ANNALS OF NEUROLOGY

Cell surface associated glycohydrolases in normal and Gaucher disease fibroblasts

(2012) Massimo Aureli et al.   JOURNAL OF INHERITED METABOLIC DISEASE

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Meta-analysis of Parkinson's Disease: Identification of a novel locus, RIT2

(2011) Nathan Pankratz et al.   ANNALS OF NEUROLOGY

Glucocerebrosidase gene has an alternative upstream promoter, which has features and expression characteristic of housekeeping genes

(2011) Eva Svobodová et al.   BLOOD CELLS MOLECULES AND DISEASES

Gaucher Disease Glucocerebrosidase and α-Synuclein Form a Bidirectional Pathogenic Loop in Synucleinopathies

(2011) Joseph R. Mazzulli et al.   CELL

A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing

(2011) Giulia Soldà et al.   HUMAN MOLECULAR GENETICS

miR-22 represses cancer progression by inducing cellular senescence

(2011) Dan Xu et al.   JOURNAL OF CELL BIOLOGY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Exploring the link between glucocerebrosidase mutations and parkinsonism

(2011) Wendy Westbroek et al.   TRENDS IN MOLECULAR MEDICINE

MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration

(2010) Julie A Saugstad   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A coding-independent function of gene and pseudogene mRNAs regulates tumour biology

(2010) Laura Poliseno et al.   NATURE

RNA and Disease

(2009) Thomas A. Cooper et al.   CELL

In silico and functional studies of the regulation of the glucocerebrosidase gene

(2009) Yotam N. Blech-Hermoni et al.   MOLECULAR GENETICS AND METABOLISM

Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain

(2009) Na Li et al.   NEUROBIOLOGY OF AGING

Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease

(2009) E. Sidransky et al.   NEW ENGLAND JOURNAL OF MEDICINE