Modification of single-nucleotide polymorphism in a fully humanized CYP3A mouse by genome editing technology

Genetic polymorphisms of human UDP-glucuronosyltransferase (UGT) genes and cancer risk

(2016) Dong Gui Hu et al.   DRUG METABOLISM REVIEWS

High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects

(2016) Benjamin P. Kleinstiver et al.   NATURE

CYP3A5 mediates basal and acquired therapy resistance in different subtypes of pancreatic ductal adenocarcinoma

(2016) Elisa M Noll et al.   NATURE MEDICINE

Genome-Editing Technologies: Principles and Applications

(2016) Thomas Gaj et al.   Cold Spring Harbor Perspectives in Biology

CRISPR/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice

(2016) Asami Oji et al.   Scientific Reports

Thalidomide-induced limb abnormalities in a humanized CYP3A mouse model

(2016) Yasuhiro Kazuki et al.   Scientific Reports

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature

(2015) Stefan Wolking et al.   CLINICAL PHARMACOKINETICS

Genetic variation of CYP3A5 influences paclitaxel/carboplatin-induced toxicity in Chinese epithelial ovarian cancer patients

(2015) Lei Hu et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Rationally engineered Cas9 nucleases with improved specificity

(2015) I. M. Slaymaker et al.   SCIENCE

Functional Gene Variants of CYP3A4

(2014) A N Werk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Highly stable maintenance of a mouse artificial chromosome in human cells and mice

(2013) Kanako Kazuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Efficient TALEN construction and evaluation methods for human cell and animal applications

(2013) Tetsushi Sakuma et al.   GENES TO CELLS

Multiplex Genome Engineering Using CRISPR/Cas Systems

(2013) L. Cong et al.   SCIENCE

Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA

(2013) Daisuke Mashiko et al.   Scientific Reports

Trans-chromosomic mice containing a human CYP3A cluster for prediction of xenobiotic metabolism in humans

(2012) Yasuhiro Kazuki et al.   HUMAN MOLECULAR GENETICS

PharmGKB summary

(2012) Jatinder Lamba et al.   Pharmacogenetics and Genomics

A Novel and Stable Mouse Artificial Chromosome Vector

(2012) Masato Takiguchi et al.   ACS Synthetic Biology

Pharmacogenetic biomarkers: cytochrome P450 3A5

(2011) Iain A.M. MacPhee   CLINICA CHIMICA ACTA

Mouse Models for the p53 R72P Polymorphism Mimic Human Phenotypes

(2010) F. Zhu et al.   CANCER RESEARCH

Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam

(2009) R. A. B. van Waterschoot et al.   DRUG METABOLISM AND DISPOSITION