Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Tingting Ma, Huanli Cheng, Tongxi Li, Yifan Chen, Tianying Cai, Junjie Bai, Ziming Wu, Xianming Xia, Tiancheng Liang, Yichao Du, Wenguang Fu
Summary: The study found that L-NAT can alleviate CCl4-induced liver fibrosis. L-NAT reduces liver cell damage and fibrosis by regulating the TGF-beta 1/SMAD and Hippo/YAP1 signaling pathways.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Chen He, Wenjing Wang, Guoli Wei, Yuqing Wang, Yingjie Wei, Jing Wang, Zhenhai Zhang
Summary: This study investigated the therapeutic effects of sodium alginate on hepatic fibrosis and found that sodium alginate with a viscosity of 232 mPa.s delivered at a dose of 100 mg/kg showed significant improvement in HF, reducing inflammatory markers and increasing the abundance of beneficial gut probiotics.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Xiaohe Li, Yanhua Wang, Jingjing Liang, Zhun Bi, Hao Ruan, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou, Cheng Yang
Summary: Bergenin alleviates bleomycin-induced pulmonary fibrosis in mice by inhibiting myofibroblast activation and promoting autophagy and myofibroblast apoptosis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Guangwen Shu, Chenxi Dai, Arslan Yusuf, Hui Sun, Xukun Deng
Summary: Limonin inhibits TGF-beta-induced EMT of hepatocytes and activation of HSCs in vitro and alleviates mouse CCl4-induced liver fibrosis by upregulating Smad7.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Parasitology
Ping Huang, Huihui Ma, Yun Cao, Tingzheng Zhan, Tingting Zhang, Xinyi Wang, Yanan Zhang, Jing Xu, Chaoming Xia
Summary: This study demonstrates the crucial role of hepatic stellate cells (HSCs) regulated by the TGF-beta 1/Smad signaling pathway in liver fibrosis during Schistosoma japonicum infection.
PARASITES & VECTORS
(2022)
Article
Biochemistry & Molecular Biology
Suvesh Munakarmi, Yamuna Gurau, Juna Shrestha, Prabodh Risal, Ho Sung Park, Hyun Beak Shin, Yeon Jun Jeong
Summary: This study investigates the protective role of 3,3'-diindolylmethane (DIM) in vitro and in a mouse model of liver fibrosis. The results suggest that DIM can inhibit TGF-beta 1-induced epithelial-mesenchymal transition (EMT) and attenuate liver injury and fibrosis caused by CCl4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Shiyun Pu, Jingyi Zhang, Changyu Ren, Hongjing Zhou, Yan Wang, Yuanli Wu, Shuangyu Yang, Fangyin Cao, Houfeng Zhou
Summary: This study aimed to investigate the role of montelukast, an antagonist of cysteinyl leukotriene receptor 1 (CysLTR1), in liver fibrosis. The results showed that montelukast inhibited the development of liver fibrosis and alleviated liver inflammation and injury. Furthermore, montelukast suppressed hepatic stellate cell activation by targeting the TGF β/Smad signaling pathway.
Article
Gastroenterology & Hepatology
Fei Liu, Changfeng Sun, Yuanfang Chen, Fei Du, Yuxiang Yang, Gang Wu
Summary: The study revealed that IPA intervention exacerbated CCl4-induced liver damage and fibrosis, potentially through activating HSCs via the TGF-beta 1/Smads signaling pathway. Additionally, IPA treatment did not affect malondialdehyde levels but reshaped the gut microbiota structure.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hancheng Huang, Shuchun Wei, Xiaohan Wu, Mengke Zhang, Benhong Zhou, Debin Huang, Weiguo Dong
Summary: This study identified dihydrokaempferol (DHK) as a potential compound for attenuating liver injury and fibrosis. DHK inhibits the overactivation of PARP-1 by competitively binding to its upstream residues, leading to the maintenance of NAD+ levels and inhibition of downstream signaling pathways and related cytokines. These findings provide a basis and direction for the development of anti-hepatic fibrosis lead compounds.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Chao He, Bo Shu, Yingxia Zhou, Ruizhi Zhang, Xin Yang
Summary: In this study, we found abnormal upregulation of PMP22 in TGF-β-activated HSCs and CCl4-induced hepatic fibrosis model in mice, as well as its pro-fibrotic role in aggravating TGF-β-induced HSC activation. Additionally, miR-139-5p targets the 3'UTR of PMP22 and inhibits its expression, thereby hindering TGF-β-induced HSC activation.
Article
Biochemistry & Molecular Biology
Songtao Gu, Jingjing Liang, Jianwei Zhang, Zhichao Liu, Yang Miao, Yuli Wei, Shimeng Li, Jinying Gu, Yunyao Cui, Ting Xiao, Xiaohe Li, Cheng Yang
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with unknown cause and limited treatment options. Transforming growth factor-beta 1 (TGF-beta 1) is recognized as a central pathway in pulmonary fibrosis. This study explored the potential effect and mechanism of JAK1/2 inhibitor baricitinib on reducing TGF-beta 1-induced fibroblast activation and epithelial injury, as well as attenuating bleomycin-induced pulmonary fibrosis in mice.
Article
Nutrition & Dietetics
You-Jung Hong, Gil-Hwan Kim, Yongdo Park, Hye-Jin Jo, Min-Woo Nam, Dong-Gu Kim, Hwangeui Cho, Hyun-Joo Shim, Jong-Sik Jin, Hyunsoo Rho, Chang-Yeob Han
Summary: This study demonstrates that Suaeda glauca extract (SGE) has therapeutic effects on liver fibrosis. SGE supplementation reduces liver fibrosis induced by CCl4, decreases HSC activation and inflammation, and improves blood biochemical parameters. The anti-fibrotic effects of SGE are mediated through the inhibition of TGF beta 1-Smad2/3 signaling in HSCs.
Article
Medicine, Research & Experimental
Kaveri R. Washimkar, Manendra Singh Tomar, Chirag Kulkarni, Shobhit Verma, Ashutosh Shrivastava, Naibedya Chattopadhyay, Madhav Nilakanth Mugale
Summary: This study elucidates the association of TGF-β1/Smad and Nrf2 signaling in the EMT and metabolic alterations associated with the etiology and progression of PF.
Article
Pharmacology & Pharmacy
Peng Lin, Xu Tong, Fan Xue, Chi Qianru, Tang Xinyu, Li Zhe, Bai Zhikun, Li Shu
Summary: Polystyrene nanoplastics (PS NPs) contamination has been identified as a serious health issue for humans and animals. This study found that combined exposure to PS NPs and lipopolysaccharide (LPS) exacerbated myocardial fibrosis and autophagy. The exposure disrupted myocardial structure, increased reactive oxygen species (ROS), triggered oxidative stress, and promoted the production of fibrotic proteins and collagen.
