Forces and Disease: Electrostatic force differences caused by mutations in kinesin motor domains can distinguish between disease-causing and non-disease-causing mutations

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Progress from genome-wide association studies and copy number variant studies in epilepsy

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dbNSFP v3.0: A One-Stop Database of Functional Predictions and Annotations for Human Nonsynonymous and Splice-Site SNVs

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Structure and Dynamics of Single-isoform Recombinant Neuronal Human Tubulin

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Structural Basis of Backwards Motion in Kinesin-1-Kinesin-14 Chimera: Implication for Kinesin-14 Motility

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Cytoplasmic dynein binding, run length, and velocity are guided by long-range electrostatic interactions

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Multiscale method for modeling binding phenomena involving large objects: application to kinesin motor domains motion along microtubules

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Hitting the brakes: targeting microtubule motors in cancer

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Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?

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Structural and physico-chemical effects of disease and non-disease nsSNPs on proteins

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X-ray and Cryo-EM structures reveal mutual conformational changes of Kinesin and GTP-state microtubules upon binding

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Kinesin superfamily proteins (KIFs): Various functions and their relevance for important phenomena in life and diseases

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On Human Disease-Causing Amino Acid Variants: Statistical Study of Sequence and Structural Patterns

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Human genotype–phenotype databases: aims, challenges and opportunities

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The structural kinetics of switch-1 and the neck linker explain the functions of kinesin-1 and Eg5

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De Novo Mutations in the Motor Domain of KIF1A Cause Cognitive Impairment, Spastic Paraparesis, Axonal Neuropathy, and Cerebellar Atrophy

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Computational and Experimental Approaches to Reveal the Effects of Single Nucleotide Polymorphisms with Respect to Disease Diagnostics

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The structure of apo-kinesin bound to tubulin links the nucleotide cycle to movement

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Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins

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Kinesin-8 Is a Low-Force Motor Protein with a Weakly Bound Slip State

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On the Dielectric “Constant” of Proteins: Smooth Dielectric Function for Macromolecular Modeling and Its Implementation in DelPhi

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CHARMM36 all-atom additive protein force field: Validation based on comparison to NMR data

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Understanding Molecular Effects of Naturally Occurring Genetic Differences

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Structural Basis for the ATP-Induced Isomerization of Kinesin

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Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

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Mutations in KIF11 Cause Autosomal-Dominant Microcephaly Variably Associated with Congenital Lymphedema and Chorioretinopathy

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Analyzing Effects of Naturally Occurring Missense Mutations

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The Structural Basis of Force Generation by the Mitotic Motor Kinesin-5

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Role of Kinesin-1 in the Pathogenesis of SPG10, a Rare Form of Hereditary Spastic Paraplegia

(2012) Kenji Kawaguchi   NEUROSCIENTIST

Whole-Exome Sequencing Identifies Mutations of KIF22 in Spondyloepimetaphyseal Dysplasia with Joint Laxity, Leptodactylic Type

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Probing the Structural and Energetic Basis of Kinesin–Microtubule Binding Using Computational Alanine-Scanning Mutagenesis

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Mutations in the motor and stalk domains of KIF5A in spastic paraplegia type 10 and in axonal Charcot-Marie-Tooth type 2

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Variation in genome-wide mutation rates within and between human families

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Electrostatically Biased Binding of Kinesin to Microtubules

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Insight into the molecular mechanism of the multitasking kinesin-8 motor

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Kinesins at a glance

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A novel mutation in KIF5A gene causing hereditary spastic paraplegia with axonal neuropathy

(2010) Olimpia Musumeci et al.   NEUROLOGICAL SCIENCES

CHARMM: The biomolecular simulation program

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Kinesin superfamily motor proteins and intracellular transport

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Protein Friction Limits Diffusive and Directed Movements of Kinesin Motors on Microtubules

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The Human Gene Mutation Database: 2008 update

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Complicated forms of autosomal dominant hereditary spastic paraplegia are frequent in SPG10

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A novel KIF5A/SPG10 mutation in spastic paraplegia associated with axonal neuropathy

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SPG10 is a rare cause of spastic paraplegia in European families

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The role of microtubules in processive kinesin movement

(2008) Masahide Kikkawa   TRENDS IN CELL BIOLOGY