Overcoming the plasticity of plant specialized metabolism for selective diterpene production in yeast

Tanshinol suppresses cardiac allograft rejection in a murine model

(2017) Chuanjian Lu et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis

(2016) Johan Andersen-Ranberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Improving monoterpene geraniol production through geranyl diphosphate synthesis regulation in Saccharomyces cerevisiae

(2016) Jianzhi Zhao et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Developing fermentative terpenoid production for commercial usage

(2016) Michael D Leavell et al.   CURRENT OPINION IN BIOTECHNOLOGY

Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis

(2016) Meirong Jia et al.   METABOLIC ENGINEERING

Production of the forskolin precursor 11β-hydroxy-manoyl oxide in yeast using surrogate enzymatic activities

(2016) Codruta Ignea et al.   Microbial Cell Factories

Carnosic acid biosynthesis elucidated by a synthetic biology platform

(2016) Codruta Ignea et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Probing the promiscuity ofent-kaurene oxidases via combinatorial biosynthesis

(2016) Sibongile Mafu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined metabolome and transcriptome profiling provides new insights into diterpene biosynthesis in S. pomifera glandular trichomes

(2015) Fotini A. Trikka et al.   BMC GENOMICS

Reconstructing the chemical diversity of labdane-type diterpene biosynthesis in yeast

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase

(2015) Codruta Ignea et al.   METABOLIC ENGINEERING

Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones

(2015) Juan Guo et al.   NEW PHYTOLOGIST

Carnosic acid

(2015) Simona Birtić et al.   PHYTOCHEMISTRY

Plant diterpene synthases: exploring modularity and metabolic diversity for bioengineering

(2015) Philipp Zerbe et al.   TRENDS IN BIOTECHNOLOGY

Biological evaluation of tanshindiols as EZH2 histone methyltransferase inhibitors

(2014) Jimin Woo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolic engineering of volatile isoprenoids in plants and microbes

(2014) CLAUDIA E. VICKERS et al.   PLANT CELL AND ENVIRONMENT

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Engineering Monoterpene Production in Yeast Using a Synthetic Dominant Negative Geranyl Diphosphate Synthase

(2013) Codruta Ignea et al.   ACS Synthetic Biology

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene

(2012) Aya Komori et al.   FEBS LETTERS

Positive genetic interactors of HMG2 identify a new set of genetic perturbations for improving sesquiterpene production in Saccharomyces cerevisiae

(2012) Codruta Ignea et al.   Microbial Cell Factories

Mining the Biodiversity of Plants: A Revolution in the Making

(2012) V. De Luca et al.   SCIENCE

Combinatorial biosynthesis in plants: A (p)review on its potential and future exploitation

(2011) Jacob Pollier et al.   NATURAL PRODUCT REPORTS

Evolution of Diterpene Metabolism: Sitka Spruce CYP720B4 Catalyzes Multiple Oxidations in Resin Acid Biosynthesis of Conifer Defense against Insects

(2011) B. Hamberger et al.   PLANT PHYSIOLOGY

Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control

(2010) E. Leonard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Rational Design of a Minimal and Highly Enriched CYP102A1 Mutant Library with Improved Regio-, Stereo- and Chemoselectivity

(2009) Alexander Seifert et al.   CHEMBIOCHEM

Chitin Synthase 2 Inhibitory Activity of O-Methyl Pisiferic Acid and 8,20-Dihydroxy-9(11),13-abietadien-12-one, Isolated from Chamaecyparis pisifera

(2008) Tae Hoon Kang et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch

(2008) Dana Morrone et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional plasticity of paralogous diterpene synthases involved in conifer defense

(2008) C. I. Keeling et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA