Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy

PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma

(2016) Tian Luo et al.   JOURNAL OF CONTROLLED RELEASE

Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21

(2016) XIAOFANG LI et al.   Molecular Medicine Reports

Triptolide Inhibits Lung Cancer Cell Migration, Invasion, and Metastasis

(2015) Theresa A. Reno et al.   ANNALS OF THORACIC SURGERY

Cancer statistics, 2015

(2015) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Abstract 4777: Triptolide inhibits Wnt signaling due to DNA methylation alteration that is determined by dynamic histone 3 K79 lysine methylation in NSCLC

(2015) Youqiang Li et al.   CANCER RESEARCH

Immunoliposome-mediated drug delivery to Plasmodium -infected and non-infected red blood cells as a dual therapeutic/prophylactic antimalarial strategy

(2015) Ernest Moles et al.   JOURNAL OF CONTROLLED RELEASE

Phosphonooxymethyl Prodrug of Triptolide: Synthesis, Physicochemical Characterization, and Efficacy in Human Colon Adenocarcinoma and Ovarian Cancer Xenografts

(2015) Satish Patil et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Carbonic Anhydrase IX Activity and Expression

(2015) Brian Mahon et al.   MOLECULES

Paclitaxel loaded liposomes decorated with a multifunctional tandem peptide for glioma targeting

(2014) Yayuan Liu et al.   BIOMATERIALS

Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102

(2014) John M. Fidler et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Carbonic anhydrase IX-directed immunoliposomes for targeted drug delivery to human lung cancer cells in vitro

(2014) Zhijun Yang et al.   Drug Design Development and Therapy

Monoclonal antibody disulfide reduction during manufacturing

(2013) Katariina M. Hutterer et al.   mAbs

Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo

(2013) Tuo Wei et al.   NANO LETTERS

Stimuli-responsive nanocarriers for drug delivery

(2013) Simona Mura et al.   NATURE MATERIALS

Multiple Binding Modes of Inhibitors to Carbonic Anhydrases: How to Design Specific Drugs Targeting 15 Different Isoforms?

(2012) Vincenzo Alterio et al.   CHEMICAL REVIEWS

Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy

(2012) A. McIntyre et al.   CLINICAL CANCER RESEARCH

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms

(2012) Zhao-Li Zhou et al.   NATURAL PRODUCT REPORTS

Advanced procedures for labeling of antibodies with quantum dots

(2011) Wael Mahmoud et al.   ANALYTICAL BIOCHEMISTRY

Lung cancer: New biological insights and recent therapeutic advances

(2011) Suresh S. Ramalingam et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A nanovector with complete discrimination for targeted delivery to Plasmodium falciparum-infected versus non-infected red blood cells in vitro

(2011) Patricia Urbán et al.   JOURNAL OF CONTROLLED RELEASE

Opsonization, Biodistribution, Cellular Uptake and Apoptosis Study of PEGylated PBCA Nanoparticle as Potential Drug Delivery Carrier

(2011) Kiran Ramanlal Chaudhari et al.   PHARMACEUTICAL RESEARCH

Antibody derivatization and conjugation strategies: Application in preparation of stealth immunoliposome to target chemotherapeutics to tumor

(2010) Arehalli S. Manjappa et al.   JOURNAL OF CONTROLLED RELEASE

Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance

(2010) O. B. Garbuzenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A clinical phase I/II trial with the monoclonal antibody cG250 (RENCAREX®) and interferon-alpha-2a in metastatic renal cell carcinoma patients

(2010) M. Siebels et al.   WORLD JOURNAL OF UROLOGY

Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target

(2009) Giuseppina De Simone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The targeting of 14-succinate triptolide-lysozyme conjugate to proximal renal tubular epithelial cells

(2008) Zhirong Zhang et al.   BIOMATERIALS

Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH

(2008) J. Chiche et al.   CANCER RESEARCH