Preclinical antileukemic activity, toxicology, toxicokinetics and formulation development of triptolide derivative MRx102

Natural Product Triptolide Mediates Cancer Cell Death by Triggering CDK7-Dependent Degradation of RNA Polymerase II

(2012) S. G. Manzo et al.   CANCER RESEARCH

Comparison of toxicokinetic and tissue distribution of triptolide-loaded solid lipid nanoparticles vs free triptolide in rats

(2012) Mei Xue et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

A Preclinical Evaluation of Minnelide as a Therapeutic Agent Against Pancreatic Cancer

(2012) R. Chugh et al.   Science Translational Medicine

MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML

(2011) B Z Carter et al.   LEUKEMIA

XPB, a subunit of TFIIH, is a target of the natural product triptolide

(2011) Denis V Titov et al.   Nature Chemical Biology

Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)

(2011) Ying Wang et al.   PLoS One

Preparation and anti-inflammatory activity of triptolide ethosomes in an erythema model

(2010) Jin-Guang Chen et al.   JOURNAL OF LIPOSOME RESEARCH

Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours

(2009) J.J.E.M. Kitzen et al.   EUROPEAN JOURNAL OF CANCER

Triptolide induces cell death independent of cellular responses to imatinib in blast crisis chronic myelogenous leukemia cells including quiescent CD34+ primitive progenitor cells

(2009) D. H. Mak et al.   MOLECULAR CANCER THERAPEUTICS

Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA

(2009) S. Vispe et al.   MOLECULAR CANCER THERAPEUTICS

Triptolide-Induced Transcriptional Arrest Is Associated with Changes in Nuclear Substructure

(2008) S. J. Leuenroth et al.   CANCER RESEARCH

Impact of cytogenetic and molecular prognostic markers on the clinical management of chronic lymphocytic leukemia

(2008) A. W. Hauswirth et al.   HAEMATOLOGICA