Targeted gene knock-in by CRISPR/Cas ribonucleoproteins in porcine zygotes

Generation of Knock-In Pigs Carrying Oct4-tdTomato Reporter through CRISPR/Cas9-Mediated Genome Engineering

(2016) Sisi Lai et al.   PLoS One

In vitro fertilization in pigs: New molecules and protocols to consider in the forthcoming years

(2016) Raquel Romar et al.   THERIOGENOLOGY

Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering

(2016) Yi Yang et al.   Journal of Molecular Cell Biology

One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system

(2016) Xianlong Wang et al.   Scientific Reports

Mammalian interspecies substitution of immune modulatory alleles by genome editing

(2016) Simon G. Lillico et al.   Scientific Reports

Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPR/Cas9-Induced Homology-Directed Repair in Zygotes

(2015) Xiaoyang Zhou et al.   HUMAN MUTATION

Engineering large animal models of human disease

(2015) C Bruce A Whitelaw et al.   JOURNAL OF PATHOLOGY

Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

(2015) Takeshi Maruyama et al.   NATURE BIOTECHNOLOGY

Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

(2015) Van Trung Chu et al.   NATURE BIOTECHNOLOGY

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs

(2015) Xianlong Wang et al.   Scientific Reports

Use of the CRISPR/Cas9 System to Produce Genetically Engineered Pigs from In Vitro-Derived Oocytes and Embryos1

(2014) Kristin M. Whitworth et al.   BIOLOGY OF REPRODUCTION

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

(2014) Xiaoqing Zhou et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

RNA-Guided Human Genome Engineering via Cas9

(2013) P. Mali et al.   SCIENCE

Live pigs produced from genome edited zygotes

(2013) Simon G. Lillico et al.   Scientific Reports

RNA-programmed genome editing in human cells

(2013) Martin Jinek et al.   eLife

RNA-guided genetic silencing systems in bacteria and archaea

(2012) Blake Wiedenheft et al.   NATURE

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Mouse models of cystic fibrosis: Phenotypic analysis and research applications

(2011) Martina Wilke et al.   Journal of Cystic Fibrosis

A hyperactive piggyBac transposase for mammalian applications

(2011) K. Yusa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas, the Immune System of Bacteria and Archaea

(2010) P. Horvath et al.   SCIENCE