Inhibition of the mechano-enzymatic amyloidogenesis of transthyretin: role of ligand affinity, binding cooperativity and occupancy of the inner channel

Novel Antibody for the Treatment of Transthyretin Amyloidosis

(2016) Akihiko Hosoi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Long-term treatment of transthyretin familial amyloid polyneuropathy with tafamidis: a clinical and neurophysiological study

(2016) Violaine Planté-Bordeneuve et al.   JOURNAL OF NEUROLOGY

Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis and associated cellular toxicity

(2016) Ricardo Sant'Anna et al.   Nature Communications

A novel mechano-enzymatic cleavage mechanism underlies transthyretin amyloidogenesis

(2015) J. Marcoux et al.   EMBO Molecular Medicine

Uncovering the Mechanism of Aggregation of Human Transthyretin

(2015) Lorena Saelices et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloidogenic V122I Transthyretin Variant in Elderly Black Americans

(2015) C. Cristina Quarta et al.   NEW ENGLAND JOURNAL OF MEDICINE

Repurposing Diflunisal for Familial Amyloid Polyneuropathy

(2015) John L. Berk et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Proteolytic cleavage of Ser52Pro variant transthyretin triggers its amyloid fibrillogenesis

(2014) P. P. Mangione et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid fibrils containing fragmented ATTR may be the standard fibril composition in ATTR amyloidosis

(2013) Elisabet Ihse et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

(2013) Teresa Coelho et al.   JOURNAL OF NEUROLOGY

Nearly 200 X-Ray Crystal Structures of Transthyretin: What Do They Tell Us About This Protein and the Design of Drugs for TTR Amyloidoses?

(2012) S. K. Palaninathan   CURRENT MEDICINAL CHEMISTRY

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trapping of palindromic ligands within native transthyretin prevents amyloid formation

(2010) S. E. Kolstoe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA