Cortical cells reveal APP as a new player in the regulation of GABAergic neurotransmission

APP modulates KCC2 expression and function in hippocampal GABAergic inhibition

(2017) Ming Chen et al.   eLife

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

An Optogenetic Approach for Investigation of Excitatory and Inhibitory Network GABA Actions in Mice Expressing Channelrhodopsin-2 in GABAergic Neurons

(2016) Guzel Valeeva et al.   JOURNAL OF NEUROSCIENCE

Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition

(2016) Nicolas Doyon et al.   NEURON

Impaired theta-gamma coupling in APP-deficient mice

(2016) Xiaomin Zhang et al.   Scientific Reports

Plasticity of Cortical Excitatory-Inhibitory Balance

(2015) Robert C. Froemke   Annual Review of Neuroscience

Cellular Functions of the Amyloid Precursor Protein from Development to Dementia

(2015) Rik van der Kant et al.   DEVELOPMENTAL CELL

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

(2015) Gabriele Deidda et al.   NATURE MEDICINE

Is birth a critical period in the pathogenesis of autism spectrum disorders?

(2015) Yehezkel Ben-Ari   NATURE REVIEWS NEUROSCIENCE

Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease

(2014) H. A. Born et al.   JOURNAL OF NEUROSCIENCE

The Developmental Switch in GABA Polarity Is Delayed in Fragile X Mice

(2014) Q. He et al.   JOURNAL OF NEUROSCIENCE

Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

(2014) Gabriele Deidda et al.   NATURE NEUROSCIENCE

Cation-chloride cotransporters in neuronal development, plasticity and disease

(2014) Kai Kaila et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid precursor protein controls cholesterol turnover needed for neuronal activity

(2013) Nathalie Pierrot et al.   EMBO Molecular Medicine

The amyloid precursor protein: A biochemical enigma in brain development, function and disease

(2013) Natalia N. Nalivaeva et al.   FEBS LETTERS

The Theta-Gamma Neural Code

(2013) John E. Lisman et al.   NEURON

Brain-Site-Specific Proteome Changes Induced by Neuronal P60TRP Expression

(2013) Arulmani Manavalan et al.   NEUROSIGNALS

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Amyloid precursor protein (APP) regulates synaptic structure and function

(2012) Sheue-Houy Tyan et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

What’s hAPPening at synapses? The role of amyloid β-protein precursor and β-amyloid in neurological disorders

(2012) C J Westmark   MOLECULAR PSYCHIATRY

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

Seizures and Epilepsy in Alzheimer's Disease

(2011) Daniel Friedman et al.   CNS Neuroscience & Therapeutics

Expression of GABA Signaling Molecules KCC2, NKCC1, and GAD1 in Cortical Development and Schizophrenia

(2011) T. M. Hyde et al.   JOURNAL OF NEUROSCIENCE

How Inhibition Shapes Cortical Activity

(2011) Jeffry S. Isaacson et al.   NEURON

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

The role of APP and APLP for synaptic transmission, plasticity, and network function: lessons from genetic mouse models

(2011) Martin Korte et al.   EXPERIMENTAL BRAIN RESEARCH

In the Adult Hippocampus, Chronic Nerve Growth Factor Deprivation Shifts GABAergic Signaling from the Hyperpolarizing to the Depolarizing Direction

(2010) L. Lagostena et al.   JOURNAL OF NEUROSCIENCE

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Inhibition of neuronal calcium oscillations by cell surface APP phosphorylated on T668

(2010) Susana Ferrao Santos et al.   NEUROBIOLOGY OF AGING

Beta amyloid-independent role of amyloid precursor protein in generation and maintenance of dendritic spines

(2010) K.J. Lee et al.   NEUROSCIENCE

What is the role of amyloid precursor protein dimerization?

(2010) Naouel Ben Khalifa et al.   Cell Adhesion & Migration

Amyloid Precursor Protein Regulates Cav1.2 L-type Calcium Channel Levels and Function to Influence GABAergic Short-Term Plasticity

(2009) L. Yang et al.   JOURNAL OF NEUROSCIENCE

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Role of upstream stimulating factors in the transcriptional regulation of the neuron-specific K–Cl cotransporter KCC2

(2008) Marika Markkanen et al.   BRAIN RESEARCH

Discrimination of cell types in mixed cortical culture using calcium imaging: A comparison to immunocytochemical labeling

(2008) Mark Pickering et al.   JOURNAL OF NEUROSCIENCE METHODS

Development of input connections in neural cultures

(2008) J. Soriano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid precursor protein knockout mice show age-dependent deficits in passive avoidance learning

(2007) Yann Senechal et al.   BEHAVIOURAL BRAIN RESEARCH