Review
Biochemistry & Molecular Biology
Julie Mondet, Simon Chevalier, Pascal Mossuz
Summary: Deregulations of S100A8 and S100A9 genes/proteins in acute leukemias impact prognosis by affecting leukemic cell viability through various mechanisms. Therapeutic targeting of S100A8 and S100A9 shows promise in improving treatment efficiency.
Article
Biochemistry & Molecular Biology
Maria Angeles Nunez-Sanchez, Maria Antonia Martinez-Sanchez, Marina Verdejo-Sanchez, Paula Garcia-Ibanez, Alba Oliva Bolarin, Bruno Ramos-Molina, Diego A. Moreno, Antonio J. Ruiz-Alcaraz
Summary: This study analyzed the anti-leukemic activity of various phytochemicals from cruciferous foods. The results showed that sulforaphane, chlorogenic acid, and cyanidin-3-glucoside exhibited potential as anti-leukemic agents, specifically targeting AML cells. Additionally, these compounds activated the NRF2/KEAP1 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Milos Mandic, Maja Misirkic Marjanovic, Ljubica Vucicevic, Maja Jovanovic, Mihajlo Bosnjak, Vladimir Perovic, Biljana Ristic, Darko Ciric, Ljubica Harhaji-Trajkovic, Vladimir Trajkovic
Summary: In this study, we investigated the mechanisms and role of autophagy in the differentiation of HL-60 human acute myeloid leukemia cells induced by the protein kinase C (PKC) activator phorbol myristate acetate (PMA). We found that MAP kinases ERK and JNK control PMA-induced macrophage differentiation of HL-60 cells through TFEB/FOXO-mediated transcriptional activation and beclin-1-dependent post-translational activation of autophagy.
Article
Genetics & Heredity
Masoumeh Fardi, Ali Mohammadi, Behzad Baradaran, Sahar Safaee
Summary: The study suggests that ZEB2 suppression through apoptosis induction could be an effective therapeutic method for myeloid leukemia, as it induces apoptosis, modulates gene expression, and reduces cell proliferation and viability.
CURRENT GENE THERAPY
(2021)
Article
Pharmacology & Pharmacy
Kyung-Sook Chung, Chae-Bin Yoo, Jeong-Hun Lee, Hwi-Ho Lee, Sang-Eun Park, Hee-Soo Han, Su-Yeon Lee, Byoung-Mok Kwon, Jung-Hye Choi, Kyung-Tae Lee
Summary: The study shows that 2'-HCA induces apoptosis in HL-60 cells via activation of the ROS-dependent JNK pathway, suggesting its potential as a therapeutic agent for leukemia.
Article
Biochemistry & Molecular Biology
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Karthi Shanmugam, Vellingiri Vadivel, Santanu Kar Mahapatra
Summary: Myricitrin induces apoptosis in HL-60 leukemia cells by reducing mitochondrial membrane potential, increasing DNA fragmentation, inhibiting cell survival proteins, and inducing pro-apoptotic proteins.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Environmental Sciences
Yin-Chen Hsiao, Fu-Shin Chueh, Yi-Shih Ma, Jin-Cherng Lien, Te-Chun Hsia, Wen-Wen Huang, Yu-Cheng Chou, Po-Yuan Chen, Jing-Gung Chung, Hung-Yi Chen, Kuo-Ching Liu
Summary: The combination treatment of GEN and Asp shows a greater anti-leukemia activity on human leukemia HL-60 cells compared to GEN or Asp treatment alone. Suggestions that this combination may enhance the efficacy of Asp in inducing apoptosis in HL-60 cells.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amandda Evelin Silva-Carvalho, Nakaly Natiely de Oliveira, Julia Viana Lafeta Machado, Daniel Carneiro Moreira, Guilherme Dotto Brand, Jose Roberto S. A. Leite, Alexandra Placido, Peter Eaton, Felipe Saldanha-Araujo
Summary: The antioxidant peptide Salamandrin-I, isolated from the skin secretion of the fire salamander, has been found to exhibit anticancer activity in human leukemia cell line HL-60, resulting in reduced cell proliferation and cell cycle arrest. The cellular toxicity of Salamandrin-I may be related to pyroptosis, as indicated by loss of mitochondrial membrane potential and hyperexpression of inflammasome components. This study provides the first evidence of the anticancer potential of Salamandrin-I peptide and offers valuable insights for cancer therapy and drug design.
Article
Spectroscopy
Yingjia Zhao, Yunyun Zhang, Xinyue Liang, Shupeng Liu, Xiumei Cao, Na Chen, Zhenyi Chen, Jianshe Yan
Summary: In this study, Raman spectroscopy was used to monitor the differentiation process of HL-60 cells into granulocytes, showing a correlation between differentiation stages and Raman characteristic regions. Support vector machine was employed to distinguish between undifferentiated and differentiated cells, achieving an average classification accuracy exceeding 84%. The results suggest the potential application of Raman spectroscopy in monitoring cell differentiation.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Biotechnology & Applied Microbiology
Jeetesh Sharma, Punit Prabha, Rohit Sharma, Shalini Gupta, Aparna Dixit
Summary: This study demonstrated that purified differentiation-inducing principle(s) from Momordica charantia seed extract induce HL-60 cells to granulocytic lineage through ERK/MAPK signaling pathway.
Article
Biochemistry & Molecular Biology
Kamila Siedlecka-Kroplewska, Agata Wronska, Zbigniew Kmiec
Summary: Acute myeloid leukemia is characterized by uncontrolled proliferation of abnormal myeloid progenitor cells. Despite recent advances in treatment, prognosis remains poor, driving the search for new chemotherapeutics. Piceatannol shows promise as a chemotherapeutic agent for leukemia, but its use may be associated with the risk of multidrug resistance, suggesting the need for combination therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yilin Wang, Jiandong Sun, Dong Xie, Ren Zhong, Shaoyong Si, Xiaotong Liu, Zhenghai Qu, Lirong Sun, Lingzhen Wang
Summary: This study investigated the effect of UV LED on leukemia cells under hypoxia and found that UV LED exacerbated apoptosis and proliferation inhibition in HL-60 cells through the regulation of caspase 3/9 and the Bcl-2/Bax ratio-dependent pathway. The application of UV LEDs in hypoxia conditions may be a promising approach to eliminate residual drug-resistant leukemia cells in autologous grafts.
JOURNAL OF ONCOLOGY
(2022)
Article
Biology
Sha Xu, Jun Xiong, Minjuan Wu, Yu Yang, Junfeng Jiang, Haitao Ni, Yunpeng Zhao, Yue Wang
Summary: Trdmt1 is up-regulated during HL-60 cell differentiation contributing to myeloid differentiation through ceRNA activity on miR-181a to increase C/EBP alpha expression.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Rania H. H. Abd El-Hameed, Mosaad S. S. Mohamed, Samir M. M. Awad, Bardes B. B. Hassan, Marwa Abd El-Fattah Khodair, Yara E. E. Mansour
Summary: A series of benzo[h]chromenes, benzo[f]chromenes, and benzo[h]chromeno[2,3-d]pyrimidines were synthesized and compounds 5a and 6a showed promising anti-cancer activity. These compounds suppressed cell growth in HL-60 by inducing cell cycle arrest and triggering cell apoptosis.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Jihong Lin, Lei Zhang, Zhiwei Wang, Qi Guan, Kai Bao, Lan Wu
Summary: COH-203 was found to have notable time- and dose-dependent antiproliferative effects on the human acute promyelocytic leukemia HL-60 cell line, resulting in cell cycle arrest at G(2)/M phase and induction of apoptosis. Western blot analysis revealed that upregulation of cyclin B was associated with G(2)/M arrest, while downregulated expression of Bcl-2 indicated that COH-203 may induce apoptosis in HL-60 cells via the mitochondrial pathway in a caspase-dependent manner.
Article
Chemistry, Organic
Fumika Karaki, Kenji Ohgane, Hirotaka Imai, Kennosuke Itoh, Hideaki Fujii
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2017)
Article
Chemistry, Organic
Hideaki Fujii, Naoyuki Shimada, Masaki Ohtawa, Fumika Karaki, Masayoshi Koshizuka, Kohei Hayashida, Mitsuhiro Kamimura, Kazuishi Makino, Tohru Nagamitsu, Hiroshi Nagase
Article
Chemistry, Organic
Fumika Karaki, Miki Kuwada, Saki Tajiri, Misaki Kanda, Mari Yanai, Mitsuhiro Kamimura, Kennosuke Itoh, Hideaki Fujii
SYNTHETIC COMMUNICATIONS
(2019)
Article
Chemistry, Medicinal
Fumika Karaki, Sho Umemoto, Karin Ashizawa, Tomoya Oki, Noriko Sato, Takumi Ogino, Naoto Ishibashi, Ryoto Someya, Kanako Miyano, Shigeto Hirayama, Yasuhito Uezono, Hideaki Fujii
Article
Chemistry, Multidisciplinary
Kennosuke Itoh, Shun-ichi Nagao, Ken Tokunaga, Shigeto Hirayama, Fumika Karaki, Takaaki Mizuguchi, Kenichiro Nagai, Noriko Sato, Mitsuaki Suzuki, Masashi Hashimoto, Hideaki Fujii
Summary: A facile synthesis of 1,2,3,4-tetrahydroquinolines was achieved by a photoinduced formal [4+2] cycloaddition reaction, with a new Ir-III complex photosensitizer, a thiourea, and an oxidant acting cooperatively. The reaction enables the synthesis of a wide variety of tetrahydroquinolines with high trans/cis diastereoselectivity (>99:1) and constructing contiguous stereogenic centers, while demonstrating a chemoselective cleavage of an acyclic imide auxiliary.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Multidisciplinary Sciences
Ryuta Shioi, Fumika Karaki, Hiromasa Yoshioka, Tomomi Noguchi-Yachide, Minoru Ishikawa, Kosuke Dodo, Yuichi Hashimoto, Mikiko Sodeoka, Kenji Ohgane
Article
Chemistry, Medicinal
Fumika Karaki, Tomoya Oki, Yuma Sakao, Noriko Sato, Shigeto Hirayama, Kanako Miyano, Yasuhito Uezono, Hideaki Fujii
Summary: This study investigated the function of Ghrelin and its regulatory mechanism on the GHSR receptor, and identified a potential beta-arrestin-biased superagonist through different screening assays. The compound's activity was found to be partially mediated by allosteric binding based on its resistance to a competitive antagonist.
Article
Chemistry, Organic
Fumika Karaki, Takuto Kiguchi, Kennosuke Itoh, Noriko Sato, Kazuhide Konishi, Hideaki Fujii
Summary: In the inverse electron-demand Diels-Alder reactions, a mixture of 1,4-dihydropyridazine isomers is formed first and then oxidized to pyridazines. This study revealed that 1,4-dihydropyridazines formed in the reactions can be oxidized to pyridazines simply by irradiating with ultraviolet light under an air atmosphere. Experimental results suggest that singlet oxygen plays a key role in oxidizing the 1,4-dihydropyridazine molecules.
Article
Chemistry, Physical
Kennosuke Itoh, Nanase Ishii, Atsushi Takashino, Aya Hara, Satoshi Kon, Takaaki Mizuguchi, Fumika Karaki, Shigeto Hirayama, Yoshio Shibagaki, Kenichiro Nagai, Noriko Sato, Ken Tokunaga, Mitsuaki Suzuki, Masashi Hashimoto, Hideaki Fujii
Summary: In this study, a new method for synthesizing pharmacological drugs using a photosensitizer was proposed. The study showed that imidazolidines can be synthesized through a photocycloaddition reaction under specific conditions. A reaction mechanism was proposed based on quenching experiments, quantum yield, and potential measurements.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Yuya Tamura, Yasunori Minami, Yoshitake Nishiyama, Yuki Sakata, Fumika Karaki, Takamitsu Hosoya, Suguru Yoshida
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Physical
Kennosuke Itoh, Atsushi Takashino, Atsushi Ohtsuka, Mizuki Kobe, Shunsuke Sawamura, Ryo Kato, Shigeto Hirayama, Fumika Karaki, Takaaki Mizuguchi, Noriko Sato, Ken Tokunaga, Yasunori Toda, Hiroyuki Suga, Hitoshi Ishida, Hideaki Fujii
Article
Chemistry, Multidisciplinary
Suguru Yoshida, Tomoko Kuribara, Harumi Ito, Tomohiro Meguro, Yoshitake Nishiyama, Fumika Karaki, Yasutomo Hatakeyama, Yuka Koike, Isao Kii, Takamitsu Hosoya
CHEMICAL COMMUNICATIONS
(2019)
Article
Chemistry, Medicinal
Kyoko Ishikawa, Fumika Karaki, Kaoru Tayama, Eika Higashi, Shigeto Hirayama, Kennosuke Itoh, Hideaki Fujii
CHEMICAL & PHARMACEUTICAL BULLETIN
(2017)
Article
Chemistry, Medicinal
Hiromitsu Fukuda, Fumika Karaki, Kosuke Dodo, Tomomi Noguchi-Yachide, Minoru Ishikawa, Yuichi Hashimoto, Kenji Ohgane
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2017)
Article
Chemistry, Organic
Shigeto Hirayama, Koji Obayashi, Naohisa Wada, Kousuke Ohyama, Shizuho Fuku, Koji Koyano, Fumika Karaki, Kennosuke Itoh, Hiroshi Nagase, Hideaki Fujii