Auxotrophy-based High Throughput Screening assay for the identification of Bacillus subtilis stringent response inhibitors

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(2016) Jayme L. Dahlin et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

The stringent factor RelA adopts an open conformation on the ribosome to stimulate ppGpp synthesis

(2016) Stefan Arenz et al.   NUCLEIC ACIDS RESEARCH

Ribosome•RelA structures reveal the mechanism of stringent response activation

(2016) Anna B Loveland et al.   eLife

Unconventional screening approaches for antibiotic discovery

(2015) Maya A. Farha et al.   Annals of the New York Academy of Sciences

From (p)ppGpp to (pp)pGpp: Characterization of Regulatory Effects of pGpp Synthesized by the Small Alarmone Synthetase of Enterococcus faecalis

(2015) Anthony O. Gaca et al.   JOURNAL OF BACTERIOLOGY

ESKAPEing the labyrinth of antibacterial discovery

(2015) Ruben Tommasi et al.   NATURE REVIEWS DRUG DISCOVERY

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone

(2015) Wieland Steinchen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanisms Underlying Bacterial Persisters

(2014) Etienne Maisonneuve et al.   CELL

Chemistry: Chemical con artists foil drug discovery

(2014) Jonathan Baell et al.   NATURE

Broad-Spectrum Anti-biofilm Peptide That Targets a Cellular Stress Response

(2014) César de la Fuente-Núñez et al.   PLoS Pathogens

GTP Dysregulation in Bacillus subtilis Cells Lacking (p)ppGpp Results in Phenotypic Amino Acid Auxotrophy and Failure To Adapt to Nutrient Downshift and Regulate Biosynthesis Genes

(2013) A. Kriel et al.   JOURNAL OF BACTERIOLOGY

Basal Levels of (p)ppGpp in Enterococcus faecalis: the Magic beyond the Stringent Response

(2013) A. O. Gaca et al.   mBio

Positive allosteric feedback regulation of the stringent response enzyme RelA by its product

(2012) Viktoriya Shyp et al.   EMBO REPORTS

Bacterial stress responses as determinants of antimicrobial resistance

(2012) K. Poole   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Direct Regulation of GTP Homeostasis by (p)ppGpp: A Critical Component of Viability and Stress Resistance

(2012) Allison Kriel et al.   MOLECULAR CELL

Relacin, a Novel Antibacterial Agent Targeting the Stringent Response

(2012) Ezequiel Wexselblatt et al.   PLoS Pathogens

The Stringent Response of Staphylococcus aureus and Its Impact on Survival after Phagocytosis through the Induction of Intracellular PSMs Expression

(2012) Tobias Geiger et al.   PLoS Pathogens

Dissecting Complex Metabolic Integration Provides Direct Genetic Evidence for CodY Activation by Guanine Nucleotides

(2011) S. R. Brinsmade et al.   JOURNAL OF BACTERIOLOGY

The RelA/SpoT Homolog (RSH) Superfamily: Distribution and Functional Evolution of ppGpp Synthetases and Hydrolases across the Tree of Life

(2011) Gemma C. Atkinson et al.   PLoS One

ppGpp Conjures Bacterial Virulence

(2010) Z. D. Dalebroux et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

High-Precision, Whole-Genome Sequencing of Laboratory Strains Facilitates Genetic Studies

(2008) Anjana Srivatsan et al.   PLoS Genetics