Molecular Mechanism of Scanning and Start Codon Selection in Eukaryotes

Depletion of eIF4G from yeast cells narrows the range of translational efficiencies genome-wide

(2011) Eun-Hee Park et al.   BMC GENOMICS

A role for the universal Kae1/Qri7/YgjD (COG0533) family in tRNA modification

(2011) Basma El Yacoubi et al.   EMBO JOURNAL

The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1

(2011) K. N. Noble et al.   GENES & DEVELOPMENT

A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export

(2011) Ben Montpetit et al.   NATURE

mRNA helicases: the tacticians of translational control

(2011) Armen Parsyan et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An upstream ORF with non-AUG start codon is translated in vivo but dispensable for translational control of GCN4 mRNA

(2011) F. Zhang et al.   NUCLEIC ACIDS RESEARCH

Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t6A modification of tRNAs

(2011) Marie-Claire Daugeron et al.   NUCLEIC ACIDS RESEARCH

Common conformational changes induced in type 2 picornavirus IRESs by cognate trans-acting factors

(2011) Y. Yu et al.   NUCLEIC ACIDS RESEARCH

tRNA Binding Properties of Eukaryotic Translation Initiation Factor 2 fromEncephalitozoon cuniculi

(2010) Marie Naveau et al.   BIOCHEMISTRY

A single sequence context cannot satisfy all non-AUG initiator codons in yeast†

(2010) Chia-Pei Chang et al.   BMC MICROBIOLOGY

Interactions of the ribosome with mRNA and tRNA

(2010) Natalia Demeshkina et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A

(2010) Madhusudhan Srinivasan et al.   EMBO JOURNAL

Bypassing of stems versus linear base-by-base inspection of mammalian mRNAs during ribosomal scanning

(2010) Irina S Abaeva et al.   EMBO JOURNAL

Multiple elements in the eIF4G1 N-terminus promote assembly of eIF4G1•PABP mRNPsin vivo

(2010) Eun-Hee Park et al.   EMBO JOURNAL

Regulatory elements in eIF1A control the fidelity of start codon selection by modulating tRNAiMet binding to the ribosome

(2010) A. K. Saini et al.   GENES & DEVELOPMENT

Yeast 18 S rRNA Is Directly Involved in the Ribosomal Response to Stringent AUG Selection during Translation Initiation

(2010) Naoki Nemoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Eukaryotic Initiation Factor (eIF) 4G HEAT Domain Promotes Translation Re-initiation in Yeast Both Dependent on and Independent of eIF4A mRNA Helicase

(2010) Ryosuke Watanabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Indispensable N-Terminal Half of eIF3j/HCR1 Cooperates with its Structurally Conserved Binding Partner eIF3b/PRT1-RRM and with eIF1A in Stringent AUG Selection

(2010) Latifa ElAntak et al.   JOURNAL OF MOLECULAR BIOLOGY

The RNA Recognition Motif of Eukaryotic Translation Initiation Factor 3g (eIF3g) Is Required for Resumption of Scanning of Posttermination Ribosomes for Reinitiation on GCN4 and Together with eIF3i Stimulates Linear Scanning

(2010) L. Cuchalova et al.   MOLECULAR AND CELLULAR BIOLOGY

The C-Terminal Region of Eukaryotic Translation Initiation Factor 3a (eIF3a) Promotes mRNA Recruitment, Scanning, and, Together with eIF3j and the eIF3b RNA Recognition Motif, Selection of AUG Start Codons

(2010) W.-L. Chiu et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of Cell Survival and Proliferation by Mammalian Eukaryotic Initiation Factor 4B

(2010) D. Shahbazian et al.   MOLECULAR AND CELLULAR BIOLOGY

The 5′-7-Methylguanosine Cap on Eukaryotic mRNAs Serves Both to Stimulate Canonical Translation Initiation and to Block an Alternative Pathway

(2010) Sarah F. Mitchell et al.   MOLECULAR CELL

Synergistic activation of eIF4A by eIF4B and eIF4G

(2010) Klaus H. Nielsen et al.   NUCLEIC ACIDS RESEARCH

eIF4G stimulates the activity of the DEAD box protein eIF4A by a conformational guidance mechanism

(2010) Manuel Hilbert et al.   NUCLEIC ACIDS RESEARCH

Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)

(2010) I. P. Ivanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Eukaryotic Ribosome

(2010) A. Ben-Shem et al.   SCIENCE

Crystal Structure of the Eukaryotic 40S Ribosomal Subunit in Complex with Initiation Factor 1

(2010) J. Rabl et al.   SCIENCE

How Does a Scanning Ribosomal Particle Move along the 5′-Untranslated Region of Eukaryotic mRNA? Brownian Ratchet Model

(2009) Alexander S. Spirin   BIOCHEMISTRY

IRES-induced conformational changes in the ribosome and the mechanism of translation initiation by internal ribosomal entry

(2009) Christopher U.T. Hellen   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Upstream sequence elements direct post-transcriptional regulation of gene expression under stress conditions in yeast

(2009) Craig Lawless et al.   BMC GENOMICS

Topology and Regulation of the Human eIF4A/4G/4H Helicase Complex in Translation Initiation

(2009) Assen Marintchev et al.   CELL

Eukaryotic and archaeal translation initiation factor 2: A heterotrimeric tRNA carrier

(2009) Emmanuelle Schmitt et al.   FEBS LETTERS

Intrinsic RNA Binding by the Eukaryotic Initiation Factor 4F Depends on a Minimal RNA Length but Not on the m7G Cap

(2009) Nicholas M. Kaye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context

(2009) Hitoshi Miyasaka et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

eIF1 Controls Multiple Steps in Start Codon Recognition during Eukaryotic Translation Initiation

(2009) Jagpreet S. Nanda et al.   JOURNAL OF MOLECULAR BIOLOGY

The Sua5 Protein Is Essential for Normal Translational Regulation in Yeast

(2009) C. A. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Control of translation initiation involves a factor-induced rearrangement of helix 44 of 16S ribosomal RNA

(2009) Daoming Qin et al.   MOLECULAR MICROBIOLOGY

Position of eukaryotic translation initiation factor eIF1A on the 40S ribosomal subunit mapped by directed hydroxyl radical probing

(2009) Yingpu Yu et al.   NUCLEIC ACIDS RESEARCH

The universal YrdC/Sua5 family is required for the formation of threonylcarbamoyladenosine in tRNA

(2009) B. El Yacoubi et al.   NUCLEIC ACIDS RESEARCH

The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis

(2009) Armen Parsyan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

(2009) N. T. Ingolia et al.   SCIENCE

Comprehensive Molecular Structure of the Eukaryotic Ribosome

(2009) Derek J. Taylor et al.   STRUCTURE

Translation Initiation on Mammalian mRNAs with Structured 5′UTRs Requires DExH-Box Protein DHX29

(2008) Vera P. Pisareva et al.   CELL

General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation

(2008) Yuri V Svitkin et al.   EMBO JOURNAL

Ribosomal position and contacts of mRNA in eukaryotic translation initiation complexes

(2008) Andrey V Pisarev et al.   EMBO JOURNAL

Bringing order to translation: the contributions of transfer RNA anticodon-domain modifications

(2008) Paul F Agris   EMBO REPORTS

eIF3a cooperates with sequences 5' of uORF1 to promote resumption of scanning by post-termination ribosomes for reinitiation on GCN4 mRNA

(2008) B. Szamecz et al.   GENES & DEVELOPMENT

Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNAMet and AUG selection

(2008) J. Dong et al.   GENES & DEVELOPMENT

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy

(2008) Francisco Ramírez-Valle et al.   JOURNAL OF CELL BIOLOGY

Crystal Structure of the Intact Archaeal Translation Initiation Factor 2 Demonstrates Very High Conformational Flexibility in the α- and β-Subunits

(2008) Elena Stolboushkina et al.   JOURNAL OF MOLECULAR BIOLOGY

Translation Initiation Factor 2  Mutant Alters Start Codon Selection Independent of Met-tRNA Binding

(2008) P. V. Alone et al.   MOLECULAR AND CELLULAR BIOLOGY

Requirement of RNA Binding of Mammalian Eukaryotic Translation Initiation Factor 4GI (eIF4GI) for Efficient Interaction of eIF4E with the mRNA Cap

(2008) A. Yanagiya et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinetic Checkpoint at a Late Step in Translation Initiation

(2008) Pohl Milon et al.   MOLECULAR CELL

ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding

(2008) F. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the yeast eIF4A-eIF4G complex: An RNA-helicase controlled by protein-protein interactions

(2008) P. Schutz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation

(2008) S. E. Kolitz et al.   RNA

Interactions between eIF4AI and its accessory factors eIF4B and eIF4H

(2008) N. Rozovsky et al.   RNA

Viral IRES RNA structures and ribosome interactions

(2008) Jeffrey S. Kieft   TRENDS IN BIOCHEMICAL SCIENCES