A triterpenoid from wild bitter gourd inhibits breast cancer cells

Cucurbitacin B Alters the Expression of Tumor-Related Genes by Epigenetic Modifications in NSCLC and Inhibits NNK-Induced Lung Tumorigenesis

(2015) S. Shukla et al.   Cancer Prevention Research

BX795, a TBK1 inhibitor, exhibits antitumor activity in human oral squamous cell carcinoma through apoptosis induction and mitotic phase arrest

(2015) Li-Yuan Bai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Alpha-momorcharin (α-MMC) exerts effective anti-human breast tumor activities but has a narrow therapeutic window in vivo

(2015) Dongliang Cao et al.   FITOTERAPIA

Cucurbitacin B induces DNA damage and autophagy mediated by reactive oxygen species (ROS) in MCF-7 breast cancer cells

(2015) Guowen Ren et al.   Journal of Natural Medicines

Bioactive polypeptides from marine-derived fungi, Trichoderma spp. by LC-MS/MS and molecular networking analysis

(2015) CC Liaw   PLANTA MEDICA

Alphitolic acid, an anti-inflammatory triterpene, induces apoptosis and autophagy in oral squamous cell carcinoma cells, in part, through a p53-dependent pathway

(2015) Li-Yuan Bai et al.   Journal of Functional Foods

Autophagy and apoptosis: where do they meet?

(2014) Subhadip Mukhopadhyay et al.   APOPTOSIS

Roles of Oxidative Stress in the Development and Progression of Breast Cancer

(2014) Ali Reza Nourazarian et al.   Asian Pacific Journal of Cancer Prevention

Cancer statistics, 2014

(2014) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Bisdemethoxycurcumin suppresses MCF-7 cells proliferation by inducing ROS accumulation and modulating senescence-related pathways

(2014) Ying-Bo Li et al.   Pharmacological Reports

Chemopreventive effect of apple and berry fruits against colon cancer

(2014) Saravana Kumar Jaganathan   WORLD JOURNAL OF GASTROENTEROLOGY

Contribution of p53 to Metastasis

(2014) E. Powell et al.   Cancer Discovery

OSU-A9, an indole-3-carbinol derivative, induces cytotoxicity in acute myeloid leukemia through reactive oxygen species-mediated apoptosis

(2013) Li-Yuan Bai et al.   BIOCHEMICAL PHARMACOLOGY

G15, a GPR30 antagonist, induces apoptosis and autophagy in human oral squamous carcinoma cells

(2013) Li-Yuan Bai et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cucurbitane Triterpenoid fromMomordica charantiaInduces Apoptosis and Autophagy in Breast Cancer Cells, in Part, through Peroxisome Proliferator-Activated ReceptorγActivation

(2013) Jing-Ru Weng et al.   Evidence-based Complementary and Alternative Medicine

EMCD, a hypoglycemic triterpene isolated from Momordica charantia wild variant, attenuates TNF-α-induced inflammation in FL83B cells in an AMP-activated protein kinase-independent manner

(2012) Hsueh-Ling Cheng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Wild bitter melon (Momordica charantia Linn. var. abbreviata Ser.) extract and its bioactive components suppress Propionibacterium acnes-induced inflammation

(2012) Chin Hsu et al.   FOOD CHEMISTRY

Inhibition of Nuclear Transcription Factor-κB and Activation of Peroxisome Proliferator-Activated Receptors in HepG2 Cells by Cucurbitane-Type Triterpene Glycosides from Momordica charantia

(2012) Nguyen Xuan Nhiem et al.   JOURNAL OF MEDICINAL FOOD

Global burden of cancer in 2008: a systematic analysis of disability-adjusted life-years in 12 world regions

(2012) Isabelle Soerjomataram et al.   LANCET

Bioactive Dietary Supplements Reactivate ER Expression in ER-Negative Breast Cancer Cells by Active Chromatin Modifications

(2012) Syed M. Meeran et al.   PLoS One

Resveratrol, through NF-Y/p53/Sin3/HDAC1 complex phosphorylation, inhibits estrogen receptor α gene expression via p38MAPK/CK2 signaling in human breast cancer cells

(2011) Francesca De Amicis et al.   FASEB JOURNAL

Wild bitter gourd extract up-regulates mRNA expression of PPARα, PPARγ and their target genes in C57BL/6J mice

(2011) Che-Yi Chao et al.   JOURNAL OF ETHNOPHARMACOLOGY

The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor

(2010) J. J. Manfredi   GENES & DEVELOPMENT

Dietary Bitter Melon Seed Increases Peroxisome Proliferator-Activated Receptor-γ Gene Expression in Adipose Tissue, Down-Regulates the Nuclear Factor-κB Expression, and Alleviates the Symptoms Associated with Metabolic Syndrome

(2010) Vidya Gadang et al.   JOURNAL OF MEDICINAL FOOD

Bitter Melon: Antagonist to Cancer

(2010) Pratibha Nerurkar et al.   PHARMACEUTICAL RESEARCH

ERα negative breast cancer cells restore response to endocrine therapy by combination treatment with both HDAC inhibitor and DNMT inhibitor

(2008) Jiang Fan et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Plant-derived compounds in clinical trials

(2007) A SAKLANI et al.   DRUG DISCOVERY TODAY