Article
Cell Biology
Myoung Seok Ko, Ji Young Yun, In-Jeoung Baek, Jung Eun Jang, Jung Jin Hwang, Seung Eun Lee, Seung-Ho Heo, David A. Bader, Chul-Ho Lee, Jaeseok Han, Jong-Seok Moon, Jae Man Lee, Eun-Gyoung Hong, In-Kyu Lee, Seong Who Kim, Joong Yeol Park, Sean M. Hartig, Un Jung Kang, David D. Moore, Eun Hee Koh, Ki-up Lee
Summary: This study revealed the role of a specific gene, pink1, in mitochondrial autophagy, where its deficiency induces dysfunction in brown adipose tissue and obesity. Surprisingly, the induction of NLRP3 did not lead to canonical inflammasome activity, but instead caused brown adipocyte precursors to differentiate into white-like adipocytes. These findings suggest a new mitochondria-NLRP3 pathway that contributes to BAT dysfunction and provide potential therapeutic targets for obesity-related metabolic diseases.
Article
Immunology
Ashley M. Nelson, Alexandra A. Erdmann, Christopher L. Coe, Mark B. Juckett, Keayra Morris, Jennifer M. Knight, Peiman Hematti, Erin S. Costanzo
Summary: Increased synthesis and release of inflammatory signalling proteins are common among individuals with hematologic malignancies undergoing hematopoietic cell transplantation (HCT). This study examined the relationship between markers of inflammatory activity and depression symptoms following HCT. The results showed that patients with elevated levels of IL-6 and IL-10 reported more severe depression symptoms post-HCT, especially in terms of neurovegetative symptoms.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Pharmacology & Pharmacy
Huiping Huang, Qingxia Liu, Xiaohan Zhang, Helin Xie, Maobai Liu, Nupur Chaphekar, Xuemei Wu
Summary: This study comprehensively evaluated published population pharmacokinetic models of Busulfan, and found that the model developed by Huang et al. exhibited satisfactory predictive performance, which can guide individualized dosage adjustment in Chinese patients.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Plant Sciences
Xiaohui Wang, Lu Wang, Renchao Dong, Kai Huang, Changyuan Wang, Jiangning Gu, Haifeng Luo, Kexin Liu, Jingjing Wu, Huijun Sun, Qiang Meng
Summary: Luteolin effectively protects against acute liver injury induced by LPS through inhibiting the TXNIP-NLRP3 axis, thereby reducing NLRP3 inflammasome activation and liver inflammation, as well as alleviating oxidative stress and hepatocyte injury.
Article
Hematology
Kimimori Kamijo, Yoshimitsu Shimomura, Akihito Shinohara, Shohei Mizuno, Minoru Kanaya, Yoshiaki Usui, Sung-Won Kim, Takahide Ara, Ishikazu Mizuno, Takuro Kuriyama, Hideyuki Nakazawa, Ken-ichi Matsuoka, Shigeru Kusumoto, Nobuo Maseki, Masaki Yamaguchi, Takashi Ashida, Makoto Onizuka, Takahiro Fukuda, Yoshiko Atsuta, Eisei Kondo
Summary: By comparing the effects of Flu/Bu2 and Flu/Bu4 on patients with non-Hodgkin lymphoma undergoing allogeneic hematopoietic cell transplantation, the study found that Flu/Bu4 was associated with higher nonrelapse mortality and lower 5-year overall survival compared to Flu/Bu2.
ANNALS OF HEMATOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ai-Hoc Nguyen, Mohitosh Biswas, Apichaya Puangpetch, Santirhat Prommas, Samart Pakakasama, Usanarat Anurathapan, Jiratha Rachanakul, Rattanaporn Sukprasong, Nutthan Nuntharadtanaphong, Nutcha Jongjitsook, Suradej Hongeng, Chonlaphat Sukasem
Summary: This study found a significant association between the polymorphism of GSTA1 and variations in the pharmacokinetic properties of busulfan treatment in pediatric Asian patients. Patients carrying the GSTA1*B variant showed a significant impact on the PK of busulfan, with a notable augmentation in AUC.
Article
Biochemistry & Molecular Biology
Bo Li, Xuliang Zhang, Siming Huo, Jian Zhang, Jiayu Du, Bonan Xiao, Miao Song, Bing Shao, Yanfei Li
Summary: This study found that aluminum exposure can cause oxidative stress and inflammatory injury in the liver of mice, leading to the activation of the NLRP3 inflammasome and induction of pyroptosis. Additionally, it was discovered that reactive oxygen species (ROS) promotes pyroptosis by activating the NLRP3 inflammasome, exacerbating aluminum-induced liver injury.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Food Science & Technology
Xusheng Li, Haiwei Li, Dongbao Cai, Ping Li, Jietian Jin, Xinwei Jiang, Zhenhua Li, Lingmin Tian, Guobing Chen, Jianxia Sun, Weibin Bai
Summary: Pubertal mice exposed to low-dose cadmium exhibit liver inflammation and severe injury, including inflammatory hepatocyte infiltration, increased apoptotic cells, and upregulation of cytokine expression.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Cell Biology
Wenqing Mu, Guang Xu, Zhilei Wang, Qiang Li, Siqiao Sun, Qin Qin, Zhiyong Li, Wei Shi, Wenzhang Dai, Xiaoyan Zhan, Jiabo Wang, Zhaofang Bai, Xiaohe Xiao
Summary: This study found that tricyclic antidepressant nortriptyline can induce liver injury by activating the NLRP3 inflammasome, which provides insight into the mechanism of TCA-induced liver injury.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Zhao-hua Deng, Jing Zhong, Hai-lin Jiang, Hyun-Woo Jeong, Jian-wei Chen, Ya-hai Shu, Ming Tan, Ralf H. Adams, Ke-ping Xie, Qi Chen, Yang Liu
Summary: Antipsychotic agent haloperidol induces vascular defects in bone marrow, affecting hematopoiesis and hematopoietic stem/progenitor cells. This effect is reversible after withdrawal of haloperidol. Mechanistically, haloperidol blocks the secretion of VEGF-A from HSPCs.
Article
Cell & Tissue Engineering
Xiao Fang, Xiong Fang, Yujia Mao, Aaron Ciechanover, Yan Xu, Jing An, Ziwei Huang
Summary: HF51116, a novel small molecule CXCR4 antagonist, can rapidly and potently mobilize HSCs from BM to PB in mice and monkeys. It synergizes with G-CSF to enhance mobilization efficacy and engraftment of HSCs, leading to successful long-term repopulation and survival in mice. HF51116 shows promising HSC mobilization activity in monkeys and warrants further preclinical and clinical studies.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Anli Wang, Yingjie Gong, Zhixin Pei, Ling Jiang, Lingling Xia, Yonggui Wu
Summary: This study demonstrated for the first time that paeoniflorin (PF) protects against diabetic liver injury (DLI) by targeting the TXNIP-activated NLRP3 inflammasome. This has important implications for the treatment of liver complications in diabetes patients.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Dania Zhivaki, Jonathan C. Kagan
Summary: Inflammasomes play context-dependent roles in inflammation and protective immunity in vertebrates, impacting CD8+ T cell-mediated antitumor immunity in different cell types. The surprising ability of inflammasomes within hyperactive DCs to facilitate the use of tumor lysates as immunogens for promoting antitumor responses offers opportunities for future research and next-generation immunotherapy development.
TRENDS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Jiaji Hu, Zhoujie Zhu, Hanglu Ying, Jie Yao, Huabin Ma, Long Li, Yufen Zhao
Summary: The study showed that OEA can protect mice from LPS/D-Gal-induced acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation, with mechanisms possibly involving the Nrf-2/HO-1 and NLRP3 inflammasome signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Sylvain Goutelle, Yann Thoma, Roxane Buffet, Michael Philippe, Thierry Buclin, Monia Guidi, Chantal Csajka
Summary: A population PK model for busulfan MIPD was implemented and cross-validated, and is now available in the Tucuxi software.
Article
Immunology
Jianlin Qiao, Yun Liu, Xiaoqian Li, Yuan Xia, Yulu Wu, Depeng Li, Hongchun Li, Ping Ma, Feng Zhu, Zhenyu Li, Kailin Xu, Lingyu Zeng
IMMUNOLOGIC RESEARCH
(2016)
Article
Immunology
Jianlin Qiao, Yun Liu, Yulu Wu, Xiaoqian Li, Feng Zhu, Yuan Xia, Haina Yao, Peipei Chu, Hongchun Li, Ping Ma, Depeng Li, Zhenyu Li, Kailin Xu, Lingyu Zeng
INTERNATIONAL IMMUNOPHARMACOLOGY
(2015)
Article
Gastroenterology & Hepatology
Jianlin Qiao, Kunming Qi, Peipei Chu, Hongling Mi, Na Yang, Haina Yao, Yuan Xia, Zhenyu Li, Kailin Xu, Lingyu Zeng
LIVER INTERNATIONAL
(2015)
Article
Hematology
Jianlin Qiao, Lan Ding, Jinyu Fu, Haina Yao, Xiaoli Li, Chao Chen, Na Yang, Hongling Mi, Yun Liu, Peipei Chu, Yuan Xia, Xi Zhang, Kailin Xu, Lingyu Zeng
ANNALS OF HEMATOLOGY
(2017)
Article
Immunology
Jianlin Qiao, Jinyan Wu, Yuanyuan Li, Yuan Xia, Peipei Chu, Kunming Qi, Zhiling Yan, Haina Yao, Yun Liu, Kailin Xu, Lingyu Zeng
CLINICAL IMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Jianlin Qiao, Haina Yao, Yuan Xia, Peipei Chu, Mingfeng Li, Yulu Wu, Wen Li, Lan Ding, Kunming Qi, Depeng Li, Kailin Xu, Lingyu Zeng
Article
Medicine, Research & Experimental
Jianlin Qiao, Lu Liu, Yuan Xia, Wen Ju, Pingping Zhao, Yan Jiang, Mingfeng Li, Wen Li, Lan Ding, Yulu Wu, Kunming Qi, Depeng Li, Xi Zhang, Kailin Xu, Lingyu Zeng
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2018)
Letter
Oncology
Jun Li, Qi Han, Yanqing Huang, Yanhui Wei, Jie Zi, Lidong Zhao, Zhimei Cai, Xuzhang Lu, Rong Xiao, Yanming Zhang, Xiaotian Yang, Hao Xu, Naitong Sun, Wanchuan Zhuang, Zhengdong Wu, Yuan Xia, Yanli Xu, Bin He, Wei Zhu, Fengling Min, Yongchun Chen, Banghe Ding, Peimin Shi, Jing Xie, Hua Tang, Zefa Liu, Bingzong Li, Yu Sun, Hongxia Qiu, Limin Duan, Elanora Dovat, Chunhua Song, Laszlo SzeKely, Sinisa Dovat, Zheng Ge
BLOOD CANCER JOURNAL
(2022)
Article
Medicine, General & Internal
Yuan Xia, Jue Zhang, Jing Li, Lina Zhang, Jianyong Li, Lei Fan, Lijuan Chen
Summary: Neutropenia is the most frequent cytopenia following CAR-T therapy, with the incidence influenced by factors such as age, sex, disease, number of prior therapy lines, target and costimulatory domain of CAR-T cells, and viral vectors used for manufacturing.
ANNALS OF MEDICINE
(2022)
Letter
Medicine, General & Internal
Yuan Xia, Yu Shi, Zhi Chen, Jue Zhang, Yu Zhu, Rui Guo, Run Zhang, Qinglin Shi, Jianyong Li, Lijuan Chen
CHINESE MEDICAL JOURNAL
(2022)
Meeting Abstract
Hematology
Yuan Xia, Run Zhang, Yuanyuan Jin, Qinglin Shi, Yujie Wu, Jianyong Li, Lijuan Chen