Synergism of ursolic acid derivative US597 with 2-deoxy-D-glucose to preferentially induce tumor cell death by dual-targeting of apoptosis and glycolysis

Synthesis, Spectral Characterization, and In Vitro Cellular Activities of Metapristone, a Potential Cancer Metastatic Chemopreventive Agent Derived from Mifepristone (RU486)

(2014) Jichuang Wang et al.   AAPS Journal

Synergistic effect and mechanism of vitamin A and vitamin D on inducing apoptosis of prostate cancer cells

(2013) Jianjun Sha et al.   MOLECULAR BIOLOGY REPORTS

A phase I dose-escalation trial of 2-deoxy-d-glucose alone or combined with docetaxel in patients with advanced solid tumors

(2012) Luis E. Raez et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Intracellular distribution and mechanisms of actions of photosensitizer Zinc(II)-phthalocyanine solubilized in Cremophor EL against human hepatocellular carcinoma HepG2 cells

(2012) Jingwei Shao et al.   CANCER LETTERS

Mitochondria-Targeted Drugs Synergize with 2-Deoxyglucose to Trigger Breast Cancer Cell Death

(2012) G. Cheng et al.   CANCER RESEARCH

Inhibition of human hepatocellular carcinoma HepG2 by phthalocyanine photosensitiser PHOTOCYANINE: ROS production, apoptosis, cell cycle arrest

(2012) Jingwei Shao et al.   EUROPEAN JOURNAL OF CANCER

Synthesis and antitumor activity of emodin quaternary ammonium salt derivatives

(2012) Jingwei Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological activity evaluation of emodin quaternary ammonium salt derivatives as potential anticancer agents

(2012) Wenfeng Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Enhanced Radiosensitivity and Chemosensitivity of Breast Cancer Cells by 2-Deoxy-D-Glucose in Combination Therapy

(2012) Fahimeh Aghaee et al.   Journal of Breast Cancer

Ursolic Acid Inhibits the Initiation, Progression of Prostate Cancer and Prolongs the Survival of TRAMP Mice by Modulating Pro-Inflammatory Pathways

(2012) Muthu K. Shanmugam et al.   PLoS One

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

(2012) Steven D. Kunkel et al.   PLoS One

FTS and 2-DG induce pancreatic cancer cell death and tumor shrinkage in mice

(2012) L Goldberg et al.   Cell Death & Disease

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

(2011) Jun Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

2-Deoxyglucose Induces Noxa-Dependent Apoptosis in Alveolar Rhabdomyosarcoma

(2011) S. Ramirez-Peinado et al.   CANCER RESEARCH

Synthesis and bioactivity of novel nitric oxide-releasing ursolic acid derivatives

(2011) Li Chen et al.   CHINESE CHEMICAL LETTERS

In vitro and in vivo anticancer activity evaluation of ursolic acid derivatives

(2011) Jing-Wei Shao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic targeting of cancer cell metabolism

(2011) Chi V. Dang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Targeting cancer metabolism: a therapeutic window opens

(2011) Matthew G. Vander Heiden   NATURE REVIEWS DRUG DISCOVERY

Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines

(2011) Chun-Yin Huang et al.   TOXICOLOGY IN VITRO

Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus

(2010) Oxana B. Kazakova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

2-Deoxy-d-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion

(2010) Haibin Xi et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin–nicotinamide-induced diabetic mice

(2010) Jin Lee et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Inhibitory effect of ursolic acid derivatives on hydrogen peroxide- and glutathione-mediated degradation of hemin: A possible additional mechanism of action for antimalarial activity

(2010) Catherine Mullié et al.   EXPERIMENTAL PARASITOLOGY

HexServer: an FFT-based protein docking server powered by graphics processors

(2010) G. Macindoe et al.   NUCLEIC ACIDS RESEARCH

Downregulation of survivin and activation of caspase-3 through the PI3K/Akt pathway in ursolic acid-induced HepG2 cell apoptosis

(2009) Cong Tang et al.   ANTI-CANCER DRUGS

The Glycolytic Inhibitor 2-Deoxyglucose Activates Multiple Prosurvival Pathways through IGF1R

(2009) Diansheng Zhong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oleanolic acid and ursolic acid induce apoptosis in four human liver cancer cell lines

(2009) Sheng-lei Yan et al.   TOXICOLOGY IN VITRO

The synthesis of ursolic acid derivatives with cytotoxic activity and the investigation of their preliminary mechanism of action

(2008) Yan-Qiu Meng et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-dependent inhibition of bladder and pancreatic cancer cell growth by 2-substituted glycyrrhetinic and ursolic acid derivatives

(2008) Gayathri Chadalapaka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and Anti-tumor Activity of Novel Amide Derivatives of Ursolic Acid

(2008) D LIU   CHEMICAL RESEARCH IN CHINESE UNIVERSITIES

Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition

(2008) Simone C.B. Gnoatto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis

(2008) Shaopeng Yuan et al.   FASEB JOURNAL

Antioxidative characteristics of aqueous and ethanol extracts of glossy privet fruit

(2008) Zhi-hong Wang et al.   FOOD CHEMISTRY

The effects of water-soluble polymers on hydroxypropyl-β-cyclodextrin solubilization of oleanolic acid and ursolic acid

(2008) Peng Quan et al.   JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY

Pharmacomodulation on the 3-acetylursolic acid skeleton: Design, synthesis, and biological evaluation of novel N-{3-[4-(3-aminopropyl)piperazinyl]propyl}-3-O-acetylursolamide derivatives as antimalarial agents

(2007) Simone C.B. Gnoatto et al.   BIOORGANIC & MEDICINAL CHEMISTRY