Correlation between NS5A Dimerization and Hepatitis C Virus Replication

Discovery of Potent Hepatitis C Virus NS5A Inhibitors with Dimeric Structures

(2011) Julie A. Lemm et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Domain 3 of NS5A Protein from the Hepatitis C Virus Has Intrinsic α-Helical Propensity and Is a Substrate of Cyclophilin A

(2011) Dries Verdegem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The effects of NS5A inhibitors on NS5A phosphorylation, polyprotein processing and localization

(2011) D. Qiu et al.   JOURNAL OF GENERAL VIROLOGY

Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner

(2011) T. L. Foster et al.   JOURNAL OF VIROLOGY

Small Molecules Targeting Hepatitis C Virus-Encoded NS5A Cause Subcellular Redistribution of Their Target: Insights into Compound Modes of Action

(2011) P. Targett-Adams et al.   JOURNAL OF VIROLOGY

Resistance Analysis of the Hepatitis C Virus NS5A Inhibitor BMS-790052 in an In Vitro Replicon System

(2010) R. A. Fridell et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HCV resistance to cyclosporin A does not correlate with a resistance of the NS5A–cyclophilin A interaction to cyclophilin inhibitors

(2010) Udayan Chatterji et al.   JOURNAL OF HEPATOLOGY

The use of AlphaLISA technology to detect interaction between hepatitis C virus-encoded NS5A and cyclophilin A

(2010) Helen Waller et al.   JOURNAL OF VIROLOGICAL METHODS

All Three Domains of the Hepatitis C Virus Nonstructural NS5A Protein Contribute to RNA Binding

(2010) T. L. Foster et al.   JOURNAL OF VIROLOGY

Hepatitis C Virus Nonstructural Protein 5A: Biochemical Characterization of a Novel Structural Class of RNA-Binding Proteins

(2010) J. Hwang et al.   JOURNAL OF VIROLOGY

Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

(2010) Min Gao et al.   NATURE

Cyclosporine Inhibits a Direct Interaction between Cyclophilins and Hepatitis C NS5A

(2010) Fiona Fernandes et al.   PLoS One

DEB025 (Alisporivir) Inhibits Hepatitis C Virus Replication by Preventing a Cyclophilin A Induced Cis-Trans Isomerisation in Domain II of NS5A

(2010) Lotte Coelmont et al.   PLoS One

A Major Determinant of Cyclophilin Dependence and Cyclosporine Susceptibility of Hepatitis C Virus Identified by a Genetic Approach

(2010) Feng Yang et al.   PLoS Pathogens

Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles

(2009) Wagane J. A. Benga et al.   HEPATOLOGY

Hepatitis C Virus NS5A Protein Is a Substrate for the Peptidyl-prolylcis/transIsomerase Activity of Cyclophilins A and B

(2009) Xavier Hanoulle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Domain III of NS5A contributes to both RNA replication and assembly of hepatitis C virus particles

(2009) M. Hughes et al.   JOURNAL OF GENERAL VIROLOGY

Identification of Hepatitis C Virus NS5A Inhibitors

(2009) J. A. Lemm et al.   JOURNAL OF VIROLOGY

Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

(2009) R. A. Love et al.   JOURNAL OF VIROLOGY

Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles

(2008) T. Masaki et al.   JOURNAL OF VIROLOGY

Essential Role of Domain III of Nonstructural Protein 5A for Hepatitis C Virus Infectious Particle Assembly

(2008) Nicole Appel et al.   PLoS Pathogens