Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders

Inhibition of cholinesterase and monoamine oxidase-B activity by Tacrine–Homoisoflavonoid hybrids

(2013) Yang Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism

(2013) Mohammadreza Jalali-Nadoushan et al.   BRAIN RESEARCH

Advances in the development of Rho-associated protein kinase (ROCK) inhibitors

(2013) Peichen Pan et al.   DRUG DISCOVERY TODAY

Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity

(2013) Daqian Zhu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fasudil and its analogs: a new powerful weapon in the long war against central nervous system disorders?

(2013) Meihui Chen et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Rho kinase inhibitors: a patent review (2012 – 2013)

(2013) Yangbo Feng et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ibuprofen and Lipoic Acid Conjugate Neuroprotective Activity Is Mediated by Ngb/Akt Intracellular Signaling Pathway in Alzheimer's Disease Rat Model

(2013) Susi Zara et al.   GERONTOLOGY

Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy

(2013) Xi Xie et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neuroprotective Actions of Methylene Blue and Its Derivatives

(2012) Ethan Poteet et al.   PLoS One

Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2)

(2012) Roberta Pireddu et al.   MedChemComm

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

(2011) Michela Rosini et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Vasospasm After Aneurysmal Subarachnoid Hemorrhage: Review of Randomized Controlled Trials and Meta-Analyses in the Literature

(2011) Gregory J. Velat et al.   World Neurosurgery

Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry

(2009) Huaying Chen et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY