Article
Chemistry, Multidisciplinary
Simon Nussbaum, Etienne Socie, George C. Fish, Nicolas J. Diercks, Hannes Hempel, Dennis Friedrich, Jacques-E. Moser, Jun-Ho Yum, Kevin Sivula
Summary: Incorporating organic semiconducting spacer cations into layered lead halide perovskite structures can mitigate dielectric and quantum confinement effects by inducing charge-transfer between the organic and inorganic layers. This study reports the synthesis and characterization of novel DJ-phase organic-inorganic layered perovskite semiconductors with a naphthalene diimide (NDI) based spacer cation that can accept photogenerated electrons from the inorganic layer. The NDI-based thin film with a 6-carbon alkyl chain length exhibited high electron mobility and trap passivation by the NDI spacer cation.
Article
Engineering, Environmental
Wei-Guang Chen, Zhi-Jian Chen, Lei Zhang, Bin Wang, Ze-Zhong Lin, Rui Cao, Wei-Rong Wang, Yu Chen, Yong Wang
Summary: A new photoresponsive luminescent material with a dynamic wide-range emission color was successfully developed by dispersing NDI-COOH into a polymer matrix. A new mechanism involving twice energy transfer between NDI and NDI radical anions for photo-enhanced RTP luminescence was presented.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Energy & Fuels
Pengzhi Bei, Antony Rajendran, Jie Feng, Wen-Ying Li
Summary: This study analyzes the structural properties of anthracene and phenanthrene to select suitable solvents for their separation. Naphthalene-based solvents with electron-withdrawing substituents are used to recognize and separate phenanthrene molecules via electrostatic interaction. The results show that acetylnaphthalene exhibits superior separation performance, with a purity of 99.3 wt% and a yield of 70.2 wt%, while also having lower viscosity and economic cost savings. The nonbonded interaction energy is further decomposed to illustrate the separation mechanism of naphthalene-based solvents, highlighting the importance of electrostatic interaction.
Article
Chemistry, Multidisciplinary
Andreas Leng, Cornelius Weiss, Nina Strassner, Andreas Hirsch
Summary: An unprecedented compound class of functional organic hybrids consisting of a photoswitchable norbornadiene building block and a redoxactive chromophore, namely naphthalene diimide, were designed and synthesized. The capability of rylene chromophores to function as a redox active catalyst upon their photoexcitation was utilized to initiate the oxidative back-conversion of the in situ formed quadricyclane unit to its norbornadiene analogue. Controlled photoswitching between the two isomerical states of the hybrids was achieved through successive photoexcitation at two different wavelengths. The reaction rate was found to be dependent on the intramolecular distance of the two functional molecular building blocks as well as the concentration of the photoexcited sample. Quantum chemical investigations supported the experimental findings and interpretations.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Huihui Zhu, Pengfei Hao, Qiu Shen, Junju Shen, Gaopeng Li, Guozheng Zhao, Haoyu Xing, Yunlong Fu
Summary: Four naphthalene diimide-based organic molecules with different supramolecular networks and photoinduced electron transfer properties have been synthesized, showing distinct photoresponsive behaviors influenced by the introduction of electron-rich solvents. The study illustrates the impact of electron-rich solvents on resultant supramolecular networks and tunable photoresponsive properties.
Article
Chemistry, Physical
Jian-Jun Liu, Jia-Jia Fu, Teng Liu, Chi-Xian He, Fei-Xiang Cheng
Summary: Metal-organic frameworks containing photoactive ligands or components are ideal platforms for building photochromic complexes. In this study, a metal-organic framework based on a naphthalene diimide ligand and Lindqvist-type W6O192- polyanions was synthesized. The framework exhibits a cationic two-dimensional grid coordination network and shows fast responsive reversible photochromism and tunable luminescence.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Debayan Chakraborty, Deblina Sarkar, Anup Kumar Ghosh, Prasanta Kumar Das
Summary: The study synthesized amphiphilic molecules based on NDI with benzyl alcohol protected alkyl chains, and demonstrated the AIE properties of NDI-2 in a DMSO-water solvent system, as well as its selective sensing of lipase, showing high detection efficiency.
Article
Chemistry, Multidisciplinary
Man Huang, Baojuan Xi, Liwei Mi, Zhengchunyu Zhang, Weihua Chen, Jinkui Feng, Shenglin Xiong
Summary: In this study, a hybrid hierarchical microspheres structure composed of TiO2@A-MoS3@NC was constructed via a self-templating method and used as an anode material for potassium-ion batteries. The microspheres exhibited excellent potassium-storage performance.
Article
Biochemistry & Molecular Biology
Chiara Platella, Rosa Gaglione, Ettore Napolitano, Angela Arciello, Valentina Pirota, Filippo Doria, Domenica Musumeci, Daniela Montesarchio
Summary: The core-extended naphthalene diimide (c(ex)-NDI) showed different binding modes and stacking interactions when interacting with different DNA targets, making it a potential fluorescent probe for G-quadruplex structures. It mainly localizes in the G-quadruplex-rich nuclei of cancer cells, supporting its use as a specific probe for these structures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Spectroscopy
Xiaowei Mu, Xiaona Song, Dejiang Gao, Pinyi Ma, Qiong Wu, Daqian Song
Summary: A novel type of red-emitting carbon dots, TN-CDs, was created using a one-step hydrothermal approach with neutral red and tartaric acid as raw materials. TN-CDs exhibited fluorescence quenching and color change in the presence of increasing water content, and could be used for fast water detection in various organic solvents. Additionally, a reusable test strip was prepared and combined with TN-CDs for real-time, on-site visual quantitative detection of water content using smartphone software, a UV lamp, and a dark chamber.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Shelter Maswanganyi, Rashi Gusain, Neeraj Kumar, Elvis Fosso-Kankeu, Frans Boudewijn Waanders, Suprakas Sinha Ray
Summary: In this study, Bi2MoO6/rGO nanocomposites were designed and prepared for the adsorption-assisted photodegradation of naphthalene molecules in an aqueous medium. The results showed that the nanocomposites exhibited significantly improved photocatalytic efficiency under visible light, with the sample containing 2% rGO showing the best photocatalytic activity and excellent reusability for five cycles.
Article
Engineering, Chemical
Yang Cai, Xiangyu Wen, Yuwei Wang, Haoran Song, Zhuo Li, Yingna Cui, Changping Li
Summary: A novel strategy for synthesizing hyper-crosslinked polymers (HCPs) with hierarchical porous structure, high surface area, and high conjugated structure was developed, using hyperbranched polymer as precursor and investigating the effect of branching degree on porosity. The resulting HCPs exhibited excellent adsorption performance for aromatic pollutants and may offer a new approach for designing HCPs with hierarchical pores for water treatment.
SEPARATION AND PURIFICATION TECHNOLOGY
(2021)
Article
Chemistry, Inorganic & Nuclear
Jiajia Li, Yunong Qin, Yu Lei, Shifeng Li, Ling Li, Bo Ouyang, Erjun Kan, Wenming Zhang
Summary: A three-dimensional catalyst (Co-CAT/NiFe-LDH/CNFs) is successfully synthesized by in situ growth of a conductive metal-organic framework on NiFe layered double hydroxide nanosheets, which exhibits superior catalytic performance in the oxygen evolution reaction (OER) and excellent stability and high power density in a zinc-air battery.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Physical
Jihyeon Lee, Byung Gwan Park, Kiheon Sung, Hyeongeon Lee, Jihun Kim, Eonu Nam, Jeong Woo Han, Kwangjin An
Summary: This study investigates the reversible hydrogenation and dehydrogenation processes in a liquid organic hydrogen carrier (LOHC) system using a single-catalyst approach. Key hydrogen-involved catalytic behaviors, such as adsorption and migration, play crucial roles in reactivity. The findings demonstrate that employing a defective metal oxide support can facilitate these behaviors at the active sites on the catalyst surface during the LOHC process.
Article
Chemistry, Multidisciplinary
Vishal G. More, Dinesh N. Nadimetla, Geeta A. Zalmi, Vilas K. Gawade, Ratan W. Jadhav, Yogesh D. Mane, Sheshanath V. Bhosale
Summary: A new 'Off-On' system was synthesized and characterized. The system showed enhanced fluorescence upon reaction with trifluoroacetic acid and can be used for naked eye detection of TFA vapors and triethylamine vapors.
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Ragini Agrawal, Virender Kumar Pal, Amit Singh, Thimmaiah Govindaraju
Summary: Identifying and characterizing a highly conserved antiparallel G-quadruplex (GQ)-forming DNA sequence within the SARS-CoV-2 genome, researchers developed a novel benzobisthiazole-based fluorogenic probe for specific target recognition. This probe, used in a cost-effective assay involving PCR amplification and endpoint fluorescence detection, demonstrates a potential diagnostic tool for SARS-CoV-2 clinical samples. The study suggests a general strategy that can be adapted for developing specific diagnostic assays targeting different noncanonical nucleic acid sequences.
Review
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Sumon Pratihar, Shuo Shi, Thimmaiah Govindaraju
Summary: Nucleic acid-based architectures have provided numerous opportunities for basic and applied research in DNA nanotechnology. By utilizing conventional and unconventional base pairing interactions, functional nucleic acid systems and devices that respond to changes in pH have been designed, offering biocompatibility and structural programmability. This Mini-Review highlights recent advancements in nucleic acid architectonics, particularly pH-driven molecular systems including nanoscale architectures, nanomachines, hydrogels, targeted bioimaging, and drug delivery architectures. The review concludes by emphasizing the challenges and opportunities for future developments.
Article
Biochemistry & Molecular Biology
Mouli Konar, Debasis Ghosh, Sourav Samanta, Thimmaiah Govindaraju
Summary: This study highlights the importance of investigating and addressing the adverse effects of A beta aggregation on neuronal cells, with a focus on the design and evaluation of peptidomimetics containing cyclic dipeptide units. The results suggest that the Akd(NMC) peptide with CDP units at specific positions shows promise in understanding and alleviating A beta aggregation-induced cellular toxicity and stiffness.
RSC CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Dikshaa Padhi, Thimmaiah Govindaraju
Summary: This article discusses the potential and possibilities of drug repurposing and hybrid drug design in the treatment of AD, presenting several potential drug candidates and discussing their plausible mechanisms of action.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Pandeeswar Makam, Sharma S. R. K. C. Yamijala, Venkata S. Bhadram, Linda J. W. Shimon, Bryan M. Wong, Ehud Gazit
Summary: The study presents a simple and efficient single amino acid bionanozyme that can catalyze the rapid oxidation of phenolic contaminants and detect neurotransmitters. Compared to natural enzymes, this copper-coordinated bionanozyme is more cost-effective, efficient, and versatile.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Madhu Ramesh, Chenikkayala Balachandra, Prayasee Baruah, Thimmaiah Govindaraju
Summary: Liquid-liquid phase separation (LLPS) is a complex physicochemical phenomenon mediated by multivalent transient weak interactions among macromolecules like polymers, proteins, and nucleic acids. It has implications in cellular physiology and disease conditions like cancer and neurodegenerative disorders. Limited chemical tools exist to modulate protein LLPS, and the development of small-molecule modulators (SMMs) could provide therapeutic potential for neurodegenerative disorders. Rationally designed cyclic dipeptide (CDP)-based SMMs have been shown to effectively inhibit and dissolve Zn-mediated tau LLPS condensates, as well as inhibit tau condensate-to-fibril transition, establishing a novel platform for the development of therapeutics for neurodegenerative disorders.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: This article presents a glucose-responsive smart hydrogel platform based on phenylboronic acid-functionalized natural silk fibroin protein for regulated insulin delivery. The platform provides controlled insulin release and restores blood glucose levels in diabetic conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Biswanath Maity, Hariharan Moorthy, Thimmaiah Govindaraju
Summary: Efficient delivery of bioactive ingredients into cells remains a challenge, and cell-penetrating peptides (CPPs) have emerged as promising delivery vehicles. In this study, novel CPPs derived from the flexible and disordered tail extensions of DNA-binding Ku proteins were developed. The lead CPP, Ku-P4, demonstrated high internalization efficacy and biocompatibility. The presence of proline residue was crucial for maintaining the intrinsically disordered state and biocompatibility. Biophysical and DNA binding studies revealed that Ku-P4 efficiently condensed DNA into positively charged polyplexes, which were then able to penetrate the cell membrane and deliver the plasmid DNA inside the cell. These findings suggest that these novel CPPs have the potential to enhance the cellular uptake and therapeutic efficacy of peptide-drug or gene conjugates.
ACS BIO & MED CHEM AU
(2023)
Article
Chemistry, Multidisciplinary
Sumon Pratihar, Mohamed Nabeel Mattath, Thimmaiah Govindaraju
Summary: Pathogenic genomes with noncanonical G-quadruplex (GQ) forming sequences are potential targets for diagnosis. The GQ-forming cDNA sequences of SARS-CoV-2 have been identified and validated as reliable diagnostic targets. High fidelity fluorescence detection of specific cDNA GQs derived from the SARS-CoV-2 RNA genome is demonstrated using small molecular probes.
CHEMICAL COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Sumon Pratihar, Krithi K. Bhagavath, Thimmaiah Govindaraju
Summary: Theranostics, the integration of therapy and diagnostics, is crucial for monitoring disease progression and treatment response. Advancements in medicinal chemistry and technology have led to the development of targeted therapeutic drugs that also provide real-time updates on disease progression and treatment. The inclusion of imaging in therapy has significantly improved the prognosis of devastating diseases. Theranostic agents play important roles in early-stage drug development and clinical-stage therapeutic-containing drug candidates.
RSC CHEMICAL BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Haibin Zhang, Debasis Ghosh, Thimmaiah Govindaraju, Shuo Shi
Summary: Biocomputing, using DNAs as its primary building blocks, is the most promising alternative for next-generation molecular computers. DNA nanoclusters (NCs) have unique self-assembly properties and programmability, making them promising candidates for biosensing applications. Thymine overhang-modified DNA-templated NCs are chemosensing ensembles capable of driving elementary and complex logic operations. These NCs can also be used for advanced DNA logic devices and error detection.
Article
Chemistry, Multidisciplinary
Madhu Ramesh, Thimmaiah Govindaraju
Summary: Alzheimer's disease (AD) is a progressive neurodegenerative disorder that contributes significantly to global dementia cases. The pathology of AD is characterized by the accumulation of amyloid beta plaques and tau neurofibrillary tangles. Despite a lack of complete understanding and approved treatments, research has revealed the multifactorial nature of AD. Therefore, developing multipronged approaches targeting multiple biomarkers and targets is crucial for effective diagnosis and therapeutics.
Article
Chemistry, Multidisciplinary
Mohamed Nabeel Mattath, Debasis Ghosh, Chunyan Dong, Thimmaiah Govindaraju, Shuo Shi
Summary: Boolean operations based on DNA have promising applications in biocomputing. By introducing parity generator and parity checker, bit errors can be effectively evaluated. In this study, a DNA hybrid architecture platform was constructed using a chemosensing ensemble and a binary to gray code encoder was used to convert the transmitted and received data into secure information.
MATERIALS HORIZONS
(2022)
Article
Chemistry, Multidisciplinary
Dikshaa Padhi, Chenikkayala Balachandra, Madhu Ramesh, Thimmaiah Govindaraju
Summary: A series of 2,2'-bipyridine derivatives with structurally unique biomolecular auxiliaries were synthesized and found to effectively ameliorate amyloid toxicity and oxidative stress observed in Alzheimer's disease (AD).
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Debasis Ghosh, Mouli Konar, Tanmay Mondal, Thimmaiah Govindaraju
Summary: The differential structures of designer peptidomimetics derived from amyloid beta (Aβ14-23) peptide were manipulated to stabilize distinct Cu oxidation states, which catalyzed different chemical reactions effectively. By incorporating cyclic dipeptide (CDP) and pyrene (Py) units, the Cu-chelation and self-assembly properties of Aβ14-23 peptide were tuned to form nanosheets and micelle-like core-shell structures. These structures demonstrated the ability to stabilize Cu-II and Cu-I states separately and catalyze tandem oxidative-hydrolysis and alkyne-azide cycloaddition reactions.
NANOSCALE ADVANCES
(2022)
