Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing

A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer

(2011) Hui Chen et al.   Gastric Cancer

Carcinogen-induced hepatic tumors in KLF6+/− mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation

(2011) Mirko Tarocchi et al.   HEPATOLOGY

Glucokinase links Krüppel-like factor 6 to the regulation of hepatic insulin sensitivity in nonalcoholic fatty liver disease

(2011) Lars P. Bechmann et al.   HEPATOLOGY

Chk2 splice variants express a dominant-negative effect on the wild-type Chk2 kinase activity

(2010) Elisabet Ognedal Berge et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Molecular Classification and Novel Targets in Hepatocellular Carcinoma: Recent Advancements

(2010) Yujin Hoshida et al.   SEMINARS IN LIVER DISEASE

KLF6-SV1 Is a Novel Antiapoptotic Protein That Targets the BH3-Only Protein NOXA for Degradation and Whose Inhibition Extends Survival in an Ovarian Cancer Model

(2009) A. DiFeo et al.   CANCER RESEARCH

Prostate-specific Klf6 Inactivation Impairs Anterior Prostate Branching Morphogenesis through Increased Activation of the Shh Pathway

(2009) Ching Ching Leow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted reduction of KLF6-SV1 restores chemotherapy sensitivity in resistant lung adenocarcinoma

(2009) Jaya Sangodkar et al.   LUNG CANCER

A Functional Role for KLF6-SV1 in Lung Adenocarcinoma Prognosis and Chemotherapy Response

(2008) A. DiFeo et al.   CANCER RESEARCH

Increased alternative splicing of the KLF6 tumour suppressor gene correlates with prognosis and tumour grade in patients with pancreatic cancer

(2008) Mark Hartel et al.   EUROPEAN JOURNAL OF CANCER

Ras Promotes Growth by Alternative Splicing-Mediated Inactivation of the KLF6 Tumor Suppressor in Hepatocellular Carcinoma

(2008) Steven Yea et al.   GASTROENTEROLOGY

KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis

(2008) Goutham Narla et al.   JOURNAL OF CLINICAL INVESTIGATION

Krüppel-like transcription factors: A functional family

(2007) Richard Pearson et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY