Article
Gastroenterology & Hepatology
Bo Li, Jun Zhang, Yong Chen, Qixia Wang, Li Yan, Rui Wang, Yiran Wei, Zhengrui You, Yikang Li, Qi Miao, Xiao Xiao, Min Lian, Weihua Chen, Dekai Qiu, Jingyuan Fang, M. Eric Gershwin, Ruqi Tang, Xiong Ma
Summary: The study revealed significant individual variability in the therapeutic effects of cholestyramine in icteric PBC patients. Differences in gut microbial composition and metabolites were observed between patients with superior remission (SR) and inferior remission (IR). Patients in the SR group showed enrichment of specific bacterial species producing short-chain fatty acids (SCFAs), while the IR group exhibited an increase in Klebsiella pneumonia.
Article
Multidisciplinary Sciences
Alberto Valdes, Lorena Ortega Moreno, Silvia Rojo Rello, Antonio Orduna, David Bernardo, Alejandro Cifuentes
Summary: This study aims to provide new information about the altered biomolecule profile and biological pathways in patients with SARS-CoV-2 infection. Metabolomics analysis of plasma samples from COVID-diagnosed patients revealed potential biomarkers for distinguishing between different clinical stages of the disease. The levels of these biomarkers normalized at hospital discharge, suggesting their potential as early prognosis biomarkers in COVID-19.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov, Anna Kotlyarova
Summary: Lipid metabolism is closely linked to the pathogenesis of COPD, with fatty acids playing a key role in inflammation and resolution. Specialized pro-inflammatory mediators formed from unsaturated fatty acids are under active research for potential drug development. Short-chain fatty acids also play a significant role in metabolic and immune processes related to COPD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Andrea Martinez Aguirre, Joseph A. Sorg
Summary: Clostridioides difficile, a nosocomial pathogen, is a burden to the healthcare system. Disruption of the gut microbiome, commonly caused by broad-spectrum antibiotics, creates a susceptible state for CDI. Various metabolites produced by the host and/or gut microbiota interact with C. difficile, affecting its germination, growth, and colonization. Understanding the interactions between C. difficile and the host's gut microbiome and metabolites becomes more relevant as non-antibiotic CDI treatment advances.
Review
Chemistry, Medicinal
Djenisa H. A. Rocha, Diana C. G. A. Pinto, Artur M. S. Silva
Summary: Inflammation is the organism's response to injury and a major cause of death worldwide. Chronic inflammatory diseases pose the greatest threat to human health, and seaweeds offer potential as a source of anti-inflammatory compounds for drug development.
Article
Cell Biology
Yuan Yao, Suya Feng, Xuejiao Li, Taohua Liu, Shengying Ye, Long Ma, Shuli Man
Summary: Litchi chinensis seed is rich in procyanidins, which have been shown to inhibit the proliferation and metastasis of colon cancer cells. This effect is mediated through modulation of gut microbiota, immune response, and regulation of metabolites such as acetic acid, propionic acid and butyric acid.
CELL DEATH & DISEASE
(2023)
Article
Food Science & Technology
Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin, Liming Zhao
Summary: Chitobiose and chitotriose can modulate the gut microbial community of NAFLD patients, increasing beneficial bacteria and decreasing harmful bacteria. Furthermore, the increase in targeted flora is closely related to the significant increase in total short-chain fatty acids, propionic acid, and butyric acid in the OC and TOC groups.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Food Science & Technology
K. A. Woodling, P. Chitranshi, C. C. Jacob, L. Loukotkova, L. S. Von Tungeln, G. R. Olson, R. E. Patton, S. Francke, S. R. Mog, R. P. Felton, F. A. Beland, Y. Zang, G. Gamboa da Costa
Summary: This study found that long-term consumption of BVO may lead to thyroid follicular cell hypertrophy and changes in serum thyroid-related hormone levels. Additionally, a continuous accumulation of bromide was observed in the heart, liver, and inguinal fat, indicating potential toxic reactions.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Endocrinology & Metabolism
Ninghua Li, Jing Li, Hui Wang, Jinnan Liu, Weiqin Li, Kai Yang, Xiaoxu Huo, Junhong Leng, Zhijie Yu, Gang Hu, Zhongze Fang, Xilin Yang
Summary: BCAAs in early pregnancy are positively associated with the risk of GDM, and high levels of leucine and isoleucine enhance the risk association of high SFA16:0 with GDM, independent of LPCs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Food Science & Technology
Xiao-Guo Ji, Kun-Lin Chang, Mai Chen, Liang-Liang Zhu, Arwa Osman, Hao Yin, Li-Ming Zhao
Summary: The study found that chitooligosaccharides (COS) increased the diversity of gut microbial community, particularly enriching butyric and propionic acid-producing microbiota. COS also regulated the production of various metabolites, suggesting its potential as raw materials for functional foods and health products.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Environmental Sciences
Thilina K. Jayawardana, Md Fahim Hossain, Dhruvin Patel, Susana Y. Kimura
Summary: This study characterized the stability of Haloacetonitriles (HANs) in different environments and found that HANs were stable in buffer solution and cell culture media, but volatile and photodegradation effects could occur when HANs were incubated in cell culture media in 96-well plates. Additionally, di- and tri- HANs degraded in both buffer solution and cell culture media. The results suggest that previous toxicity assessments may have underestimated the toxicity of HANs, and future evaluations should consider changing cell culture media and DBP on a daily basis for more accurate measurements.
Article
Biochemistry & Molecular Biology
Arleta Drozd, Dariusz Kotlega, Przemyslaw Nowacki, Sylwester Ciecwiez, Tomasz Trochanowski, Malgorzata Szczuko
Summary: This study investigates the role of inflammation in nondipping blood pressure and obstructive sleep apnea syndrome, and finds associations between fatty acids and their metabolites in the pathogenesis of nondipping phenomenon. Lower levels of inflammation and higher levels of anti-inflammatory mediators favor the occurrence of physiological dipping.
Article
Biology
Masato Hirota, Miho Tamai, Sachie Yukawa, Naoyuki Taira, Melissa M. Matthews, Takeshi Toma, Yu Seto, Makiko Yoshida, Sakura Toguchi, Mio Miyagi, Tomoari Mori, Hiroaki Tomori, Osamu Tamai, Mitsuo Kina, Eishin Sakihara, Chiaki Yamashiro, Masatake Miyagi, Kentaro Tamaki, Matthias Wolf, Mary K. Collins, Hiroaki Kitano, Hiroki Ishikawa
Summary: COVID-19 mRNA vaccines elicit adaptive immunity against SARS-CoV-2, but the levels of vaccine-induced responses vary among individuals. A systems biology study using multi-omics analyses of human samples identified factors associated with these immune responses. The study found that the expression of activation protein 1 (AP-1) transcription factors, influenced by commensal microbial activity, is negatively correlated with the effectiveness of the BNT162b2 vaccine in inducing T-cell responses.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rui Yang, Yanmei Dong, Fei Gao, Jingyi Li, Zora Dajic Stevanovic, Hui Li, Lei Shi
Summary: This paper assessed the bioactive compounds and antioxidant capacity of four traditionally used thyme species. The study found a positive correlation between the content of total polyphenols and total flavonoids, and their antioxidant activity. Flavonoids were identified as the key contributors to the high antioxidant capacity of thyme species.
Review
Biochemistry & Molecular Biology
Umur Keles, Jin Rong Ow, Katharina Barbara Kuentzel, Li Na Zhao, Philipp Kaldis
Summary: Excessive fat accumulation in the liver is a major health threat globally, with unresolved deposition leading to various diseases. The interaction between metabolites released from the liver and other organs plays a crucial role in the development of fatty liver disease.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Chemistry, Analytical
Julia Bornhorst, Anna P. Kipp, Hajo Haase, Soeren Meyer, Tanja Schwerdtle
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2018)
Article
Engineering, Environmental
Xi-Mei Xue, Jun Ye, Georg Raber, Barry P. Rosen, Kevin Francesconi, Chan Xiong, Zhe Zhu, Christopher Rensing, Yong-Guan Zhu
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Johannes Florian Kopp, Sandra Marie Mueller, Gabriele Pohl, Kristina Lossow, Anna Patricia Kipp, Tanja Schwerdtle
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Environmental Sciences
Nguyen Dang Giang Chau, Nguyen Van Hop, Hoang Thai Long, Ngo Thi My Duyen, Georg Raber
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
(2020)
Article
Nutrition & Dietetics
Sandra M. Mueller, Christine Dawczynski, Johanna Wiest, Stefan Lorkowski, Anna P. Kipp, Tanja Schwerdtle
Article
Biochemistry & Molecular Biology
Franziska Ebert, Vanessa Ziemann, Viktoria Klara Wandt, Barbara Witt, Sandra Marie Mueller, Nikolaus Guttenberger, Ezgi Eyluel Bankoglu, Helga Stopper, Georg Raber, Kevin A. Francesconi, Tanja Schwerdtle
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Engineering, Environmental
Ronald A. Glabonjat, Georg Raber, Henry C. Holm, Benjamin A. S. Van Mooy, Kevin A. Francesconi
Summary: The study found arsenolipids in 61 plankton samples with varying levels of nutrients in the North Atlantic Ocean. The relative amounts of six identified arsenolipids in the samples showed a clear dependence on the nutrient status of the surrounding water. By combining field data with global phytoplankton productivity, it is estimated that oceans' phytoplankton convert 50,000-100,000 tons of arsenic into arsenolipids annually.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Fabian Sandgruber, Annekathrin Gielsdorf, Anja C. Baur, Benjamin Schenz, Sandra Marie Mueller, Tanja Schwerdtle, Gabriele Stangl, Carola Griehl, Stefan Lorkowski, Christine Dawczynski
Summary: The nutrient composition of 15 commercially available microalgae powders such as Arthrospira platensis, Chlorella pyrenoidosa, and Dunaliella salina were analyzed, revealing differences in content. While Dunaliella salina powders were high in carbohydrates and fatty acids, Haematococcus pluvialis powders had significantly higher levels of carotenoids but lower levels of vitamins and proteins.
Article
Biology
Sabine Borchard, Stefanie Raschke, Krzysztof M. Zak, Carola Eberhagen, Claudia Einer, Elisabeth Weber, Sandra M. Mueller, Bernhard Michalke, Josef Lichtmannegger, Albrecht Wieser, Tamara Rieder, Grzegorz M. Popowicz, Jerzy Adamski, Martin Klingenspor, Andrew H. Coles, Ruth Viana, Mikkel H. Vendelbo, Thomas D. Sandahl, Tanja Schwerdtle, Thomas Plitz, Hans Zischka
Summary: In Wilson disease, excessive copper accumulation in the liver can potentially lead to brain damage. Current treatments focus on using high-affinity copper chelators to prevent neurological deterioration. Experimental findings suggest that ALXN1840 may protect the brain by preventing blood-brain barrier damage.
LIFE SCIENCE ALLIANCE
(2021)
Article
Chemistry, Analytical
Georg Raber, Sonja Weishaupt, Fabian Lappi, Michael Stiboller, Joerg Feldmann
Summary: A new analytical method using gas chromatography-mass spectrometry (GC-MS) was developed for the quantitative determination of arsenic-containing hydrocarbons (AsHCs) in marine samples. The novel method allows for compound independent quantification using triphenylarsine (TPA) as a commercially available standard, expanding the screening application for these toxic compounds in the environment.
ENVIRONMENTAL CHEMISTRY
(2023)
Article
Medicine, General & Internal
Cornelia Weikert, Iris Trefflich, Juliane Menzel, Rima Obeid, Alessa Longree, Jutta Dierkes, Klaus Meyer, Isabelle Herter-Aeberli, Knut Mai, Gabriele Stangl, Sandra M. Muller, Tanja Schwerdtle, Alfonso Lampen, Klaus Abraham
DEUTSCHES ARZTEBLATT INTERNATIONAL
(2020)
Article
Biochemistry & Molecular Biology
Hannah Finke, Viktoria K. Wandt, Franziska Ebert, Nikolaus Guttenberger, Ronald A. Glabonjat, Michael Stiboller, Kevin A. Francesconi, Georg Raber, Tanja Schwerdtle
Article
Chemistry, Analytical
Michael Stiboller, Fabiana P. Freitas, Kevin A. Francesconi, Tanja Schwerdtle, Antonio J. A. Nogueira, Georg Raber
JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY
(2019)
Article
Toxicology
S. M. Mueller, F. Ebert, G. Raber, S. Meyer, J. Bornhorst, S. Huwel, H. -J. Galla, K. A. Francesconi, T. Schwerdtle
ARCHIVES OF TOXICOLOGY
(2018)
Review
Toxicology
Shahid Yousuf Ganie, Darakhshan Javaid, Younis Ahmad Hajam, Mohd Salim Reshi
Summary: Arsenic toxicity is a complex and pervasive public health problem that affects millions of people worldwide. This review aims to consolidate current knowledge on arsenic toxicity, including its sources, chemical forms, and the pathways through which it affects human health. The study found that arsenic is associated with chronic diseases such as cancer, cardiovascular disorders, and neurotoxicity, and oxidative stress, genotoxicity, and epigenetic modifications play important roles in arsenic-induced cellular damage. Further research is needed to fill gaps in our understanding of arsenic toxicity and inform public health policies aimed at minimizing exposure.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Lu Zhang, Min Li, Dalong Zhang, Shujing Zhang, Li Zhang, Xiaojun Wang, Zhiyong Qian
Summary: With the increasing incidence of neurodevelopmental disorders, it is important to screen and evaluate developmental neurotoxicity (DNT) compounds from a large number of environmental chemicals and understand their mechanisms. This study conducted a DNT qualitative structure-activity relationship (QSAR) study for the first time, and preliminarily illustrated the structural characterization of DNT compounds. Multiple models and methods were used to construct prediction models, resulting in the best model with good predictive ability. By combining different models, both MCC values and application domain values were improved. Additionally, through modeling descriptors analysis and structure alerts (SAs) identification, electronical properties, van der Waals volume-related properties, and S, Cl or P containing substructure were found to be associated with DNT. This study lays a foundation for further DNT prediction of environmental exposures in human and contributes to the understanding of DNT mechanism.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Khushboo Sharma, Satish Koundal, Mandeep Singh, Pooja Chadha, Harvinder Singh Saini
Summary: The unregulated discharge of untreated or partially treated industrial wastewater poses a serious threat to aquatic ecosystems. This study exposed Channa punctata fish to untreated and microbially treated textile industry effluent to analyze their toxicity effects. The results showed that the untreated effluent group had more severe hematological, biochemical, histopathological, and ultrastructural alterations compared to the microbially treated group. This highlights the importance of finding more effective microbial treatments to protect aquatic life and human health.
TOXICOLOGY RESEARCH
(2024)
Article
Toxicology
Chen Gu, Yan Sun, Meiqi Mao, Jinguo Liu, Xiongyao Li, Xiaoping Zhang
Summary: This study investigated the mechanism of lunar dust simulant (CLDS-i) in inducing inflammatory lung injury. The results showed that CLDS-i regulated immune inflammatory cells and activated signaling pathways related to inflammatory diseases, promoting the occurrence and development of inflammatory injury. The study also found that amino acid metabolism imbalance might be related to the activation of the NF-kappa B signaling pathway.
TOXICOLOGY RESEARCH
(2024)
