Article
Nutrition & Dietetics
Qianqian Wang, Min Guo, Yang Liu, Mengshu Xu, Liuting Shi, Xiu Li, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen
Summary: This study found that certain strains of Bifidobacterium can reduce the production of plasma TMAO and modulate the gut microbiota. These strains may have therapeutic potential for preventing TMAO-related diseases such as atherosclerosis.
Article
Nutrition & Dietetics
Manman Lu, Yuhui Yang, Yuncong Xu, Xiaoyue Wang, Bo Li, Guowei Le, Yanli Xie
Summary: Dietary methionine restriction (MR) can reduce plasma trimethylamine-N-oxide (TMAO) levels by manipulating gut microbiota in mice. MR decreases the ability of gut microbiota to produce trimethylamine (TMA), reduces TMA levels and expression of choline TMA-lyase (CutC) in the intestine, and increases the abundance of SCFA-producing bacteria.
Article
Agriculture, Multidisciplinary
Shan Huang, Si Ying Lim, Sock Hwee Tan, Mark Y. Chan, Wuzhong Ni, Sam Fong Yau Li
Summary: The relationship between TMAO, betaine, and choline with acute myocardial infarction (AMI) is unclear. This study found that high betaine + low TMAO levels are associated with a significant protective effect against AMI. Furthermore, age is positively correlated with TMAO concentration, indicating a potential interplay between age and the risk of AMI associated with metabolite combination.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Nutrition & Dietetics
Katrin A. Boeckmann, Axel R. Franz, Michaela Minarski, Anna Shunova, Christian A. Maiwald, Julian Schwarz, Maximilian Gross, Christian F. Poets, Wolfgang Bernhard
Summary: The study compared four different choline supplements and their impact on plasma concentration and kinetics of choline, betaine and TMAO. Results showed that all supplements rapidly increased choline and betaine levels to a similar extent, with egg-PC having the latest peak. Egg-PC may be the best choice for choline supplementation in adults due to potentially lower TMAO production.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Article
Endocrinology & Metabolism
Shenghong Qi, Lan Liu, Shulan He, Liqun Wang, Jiangping Li, Xian Sun
Summary: This study found that serum choline concentration is significantly associated with increased risk of type 2 diabetes mellitus. Serum choline > 22.62 μmol/L is independently associated with increased risk of type 2 diabetes mellitus. Additionally, serum betaine and L-carnitine concentrations are markedly associated with decreased risk of type 2 diabetes mellitus, even after adjusting for traditional risk factors.
DIABETES METABOLIC SYNDROME AND OBESITY
(2023)
Review
Nutrition & Dietetics
Edoardo Tacconi, Giuseppe Palma, Davide De Biase, Antonio Luciano, Massimiliano Barbieri, Filomena de Nigris, Francesca Bruzzese
Summary: TMAO is a microbial metabolite that is closely related to gut microbiota and has implications for gastrointestinal cancers, cardiovascular disease, and systemic inflammation. The composition of gut microbiota plays a crucial role in the production of pro-inflammatory TMAO, and the culprits may be certain food sources such as high fat meat, offal, egg yolk, whole dairy products, and fatty fish.
Review
Pharmacology & Pharmacy
Seyyed Mostafa Arabi, Leila Sadat Bahrami, Narges Milkarizi, Mohsen Nematy, Vladislav Kalmykov, Amirhossein Sahebkar
Summary: This study analyzed eight randomized controlled trials and found that walnut consumption can reduce serum triglyceride levels in individuals with metabolic syndrome, but it has no significant effect on other cardiometabolic indices. Further well-designed and large-scale studies are needed to further explore the beneficial effects of walnut consumption on cardiometabolic profile.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Agriculture, Dairy & Animal Science
Yang Zhou, Wei Jin, Fei Xie, Shengyong Mao, Yanfen Cheng, Weiyun Zhu
Summary: The study investigated the role of Methanomassiliicoccales (Mmc) in trimethylamine (TMA) metabolism in the rumen of dairy cows through in vitro and in vivo trials. Results showed that Mmc played an important role in eliminating TMA in the rumen, leading to high levels of TMA in the blood circulation of dairy cows.
Article
Microbiology
Lesley Hoyles, Matthew G. Pontifex, Ildefonso Rodriguez-Ramiro, M. Areeb Anis-Alavi, Khadija S. Jelane, Tom Snelling, Egle Solito, Sonia Fonseca, Ana L. Carvalho, Simon R. Carding, Michael Muller, Robert C. Glen, David Vauzour, Simon McArthur
Summary: The study shows that methylamine substances can directly affect the integrity of the blood-brain barrier in mammals by improving its function through regulation of tight junction proteins. Long-term exposure to trimethylamine N-oxide helps protect cognitive function, reducing astrocyte and microglial reactivity in specific brain regions.
Review
Peripheral Vascular Disease
Minu S. Thomas, Maria Luz Fernandez
Summary: The link between plasma TMAO levels and CVD risk is established in epidemiological research, but the role of dietary precursors in determining TMAO levels is still inconclusive. Recent studies show positive associations between plasma TMAO concentrations and various CVD risk factors, but the impact of dietary choline and carnitine on chronic plasma TMAO levels and CVD risk requires further investigation.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Paulina Aldana-Hernandez, Jessy Azarcoya-Barrera, Jelske N. van der Veen, Kelly-Ann Leonard, Yuan-Yuan Zhao, Randal Nelson, Susan Goruk, Catherine J. Field, Jonathan M. Curtis, Caroline Richard, Rene L. Jacobs
Summary: Choline is an essential nutrient that plays a role in various biological processes, and the form of dietary choline intake can influence the development of atherosclerosis. Increased intake of phosphatidylcholine in the diet may reduce the risk of atherosclerosis but is associated with higher plasma TMAO levels.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Agriculture, Dairy & Animal Science
Tanya L. France, William A. Myers, Awais Javaid, Ian R. Frost, Joseph W. McFadden
Summary: The study found that plasma and milk choline, betaine, and TMAO concentrations are responsive to RPC type, dose, and stage of lactation evaluated.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Xiaojing Lin, Yunqi Zhang, Xiaoling He, Yan Chen, Nan Chen, Juncheng Liu, Miaoran Wang, Yue Li, Hong Yang, Lei Fan, Yi Hou, Jibin Li, Chaodong Wu, Hongbo Qi, Hua Zhang, Xiaoqiu Xiao
Summary: In this study, it was found that higher levels of TMAO and the formation of abnormal NETs were associated with GDM. TMAO not only promoted the development of the placenta and fetuses but also inhibited the formation of NETs.
Article
Endocrinology & Metabolism
Long Zhou, Xiang Li, Shuhong Li, Xiaoxiao Wen, Yaguang Peng, Liancheng Zhao
Summary: This study found a positive linear relationship between dietary choline intake and diabetes mellitus in the US adult population, with higher choline intake associated with increased odds of developing diabetes. The ROC analysis identified an energy-adjusted choline intake of 331.7 mg/8.37-MJ per day as the optimal cutoff value for predicting diabetes.
JOURNAL OF DIABETES
(2021)
Article
Nutrition & Dietetics
Nora A. Kalagi, Rohith N. Thota, Elizabeth Stojanovski, Khalid A. Alburikan, Manohar L. Garg
Summary: This study compared plasma TMAO levels in people with or without T2D and explored the association between TMAO and T2D. The results showed a significant association between higher plasma TMAO levels and T2D, with red meat consumption being a contributing factor. Further research is needed to assess the correlation between TMAO and T2D.
Article
Nutrition & Dietetics
Rima Obeid, Hussain M. Awwad, Yannick Rabagny, Stefan Graeber, Wolfgang Herrmann, Juergen Geisel
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2016)
Article
Biochemistry & Molecular Biology
Hussain Mohamad Awwad, Carsten-Henning Ohlmann, Michael Stoeckle, Rasul Aziz, Juergen Geisel, Rima Obeid
Article
Nutrition & Dietetics
Rima Obeid, Hussain M. Awwad, Markus Keller, Juergen Geisel
EUROPEAN JOURNAL OF NUTRITION
(2017)
Article
Biochemical Research Methods
Hussain Mohamad Awwad, Juergen Geisel, Rima Obeid
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2016)
Article
Food Science & Technology
Rima Obeid, Hussain M. Awwad, Susanne H. Kirsch, Christiane Waldura, Wolfgang Herrmann, Stefan Graeber, Juergen Geisel
MOLECULAR NUTRITION & FOOD RESEARCH
(2017)
Article
Medical Laboratory Technology
Hussain Mohamad Awwad, Carsten-Henning Ohlmann, Michael Stoeckle, Juergen Geisel, Rima Obeid
CLINICAL BIOCHEMISTRY
(2018)
Article
Food Science & Technology
Sandra Tillmann, Hussain M. Awwad, Amanda R. Eskelund, Giulia Treccani, Juergen Geisel, Gregers Wegener, Rima Obeid
MOLECULAR NUTRITION & FOOD RESEARCH
(2018)
Review
Medical Laboratory Technology
Hussain Mohamad Awwad, Juergen Geisel, Rima Obeid
CLINICAL BIOCHEMISTRY
(2012)
Article
Biochemical Research Methods
Hussain Mohamad Awwad, Susanne H. Kirsch, Juergen Geisel, Rima Obeid
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2014)
Article
Geriatrics & Gerontology
Ayman Zant, Hussain M. Awwad, Juergen Geisel, Markus Keller, Rima Obeid
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Nutrition & Dietetics
Anne-Kathrin Siebert, Rima Obeid, Stine Weder, Hussain M. Awwad, Andreas Sputtek, Juergen Geisel, Markus Keller
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2017)
Article
Medical Laboratory Technology
Hussain Mohamad Awwad, Imad Aboukhamis
CLINICAL LABORATORY
(2010)