The Role of Mechanistic Target of Rapamycin (mTOR) Complexes Signaling in the Immune Responses

Impact of Mammalian Target of Rapamycin Inhibition on Lymphoid Homing and Tolerogenic Function of Nanoparticle-Labeled Dendritic Cells following Allogeneic Hematopoietic Cell Transplantation

(2014) W. Reichardt et al.   JOURNAL OF IMMUNOLOGY

mTORC1 regulates CD8+T-cell glucose metabolism and function independently of PI3K and PKB

(2013) David K. Finlay   BIOCHEMICAL SOCIETY TRANSACTIONS

Murine dendritic cell rapamycin-resistant and rictor-independent mTOR controls IL-10, B7-H1, and regulatory T-cell induction

(2013) B. R. Rosborough et al.   BLOOD

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

(2013) Q. Liu et al.   CANCER RESEARCH

mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

(2013) Chunlei Cang et al.   CELL

Recent advances in understanding the molecular mechanisms of the development and function of Th17 cells

(2013) Yutaka Kurebayashi et al.   GENES TO CELLS

p38  Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin

(2013) K. Katholnig et al.   JOURNAL OF IMMUNOLOGY

The Peripheral NK Cell Repertoire after Kidney Transplantation is Modulated by Different Immunosuppressive Drugs

(2013) Christine Neudoerfl et al.   Frontiers in Immunology

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

New Strategies for Advanced Neuroendocrine Tumors in the Era of Targeted Therapy

(2012) M. Dong et al.   CLINICAL CANCER RESEARCH

mTOR, metabolism, and the regulation of T-cell differentiation and function

(2012) Adam T. Waickman et al.   IMMUNOLOGICAL REVIEWS

Amino acid catabolism: a pivotal regulator of innate and adaptive immunity

(2012) Tracy L. McGaha et al.   IMMUNOLOGICAL REVIEWS

A phase I/II, non-randomized, feasibility/safety and efficacy study of the combination of everolimus, cetuximab and capecitabine in patients with advanced pancreatic cancer

(2012) Sil Kordes et al.   INVESTIGATIONAL NEW DRUGS

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

(2012) Minsheng Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+T cells

(2012) David K. Finlay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mammalian Target of Rapamycin Integrates Diverse Inputs To Guide the Outcome of Antigen Recognition in T Cells

(2012) A. T. Waickman et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production

(2012) M. Ohtani et al.   JOURNAL OF IMMUNOLOGY

Metabolic Stress Controls mTORC1 Lysosomal Localization and Dimerization by Regulating the TTT-RUVBL1/2 Complex

(2012) Sang Gyun Kim et al.   MOLECULAR CELL

TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

(2012) Lianjun Zhang et al.   PLoS One

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

(2012) Margrét H. Ögmundsdóttir et al.   PLoS One

Pancreatic Neuroendocrine and Carcinoid Tumors: What’s New, What’s Old, and What’s Different?

(2012) Diane Reidy-Lagunes et al.   Current Oncology Reports

Cancer Cell Metabolism: One Hallmark, Many Faces

(2012) Jason R. Cantor et al.   Cancer Discovery

Well-differentiated Pancreatic Neuroendocrine Carcinoma in Tuberous Sclerosis—Case Report and Review of the Literature

(2011) Nicoleta C. Arva et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Sirolimus Enhances the Magnitude and Quality of Viral-Specific CD8+ T-Cell Responses to Vaccinia Virus Vaccination in Rhesus Macaques

(2011) A. P. Turner et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Temsirolimus, an mTOR inhibitor, enhances anti-tumour effects of heat shock protein cancer vaccines

(2011) Y Wang et al.   BRITISH JOURNAL OF CANCER

Transcriptional Control of Cellular Metabolism by mTOR Signaling

(2011) J. L. Yecies et al.   CANCER RESEARCH

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

(2011) Timothy R. Peterson et al.   CELL

The integral role of mTOR in lipid metabolism

(2011) Ghada A. Soliman   CELL CYCLE

Rapamycin Generates Graft-Homing Murine Suppressor CD8+ T Cells That Confer Donor-Specific Graft Protection

(2011) Basset El Essawy et al.   CELL TRANSPLANTATION

De-novo calcineurin-inhibitor-free immunosuppression with sirolimus and mycophenolate mofetil after heart transplantation

(2011) Bruno Meiser et al.   Current Opinion in Organ Transplantation

mTOR inhibition, a potential novel approach for bronchial carcinoids

(2011) Mei Dong et al.   ENDOCRINE-RELATED CANCER

Direct activation of mTOR in B lymphocytes confers impairment in B-cell maturation andloss of marginal zone B cells

(2011) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

A Central Role for mTOR Kinase in Homeostatic Proliferation Induced CD8+ T Cell Memory and Tumor Immunity

(2011) Qingsheng Li et al.   IMMUNITY

Dynamic regulation of Th17 differentiation by oxygen concentrations

(2011) A. Ikejiri et al.   INTERNATIONAL IMMUNOLOGY

Redox Regulates Mammalian Target of Rapamycin Complex 1 (mTORC1) Activity by Modulating the TSC1/TSC2-Rheb GTPase Pathway

(2011) Sei Yoshida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mTOR links oncogenic signaling to tumor cell metabolism

(2011) Jessica L. Yecies et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model

(2011) Ana Roscic et al.   JOURNAL OF NEUROCHEMISTRY

The Evolving Role of mTOR Inhibition in Transplantation Tolerance

(2011) G. McMahon et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

mTOR Kinase Domain Phosphorylation Promotes mTORC1 Signaling, Cell Growth, and Cell Cycle Progression

(2011) B. Ekim et al.   MOLECULAR AND CELLULAR BIOLOGY

The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function

(2011) Kai Yang et al.   NATURE IMMUNOLOGY

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

(2011) Greg M Delgoffe et al.   NATURE IMMUNOLOGY

Characterization of the Metabolic Phenotype of Rapamycin-Treated CD8+ T Cells with Augmented Ability to Generate Long-Lasting Memory Cells

(2011) Shan He et al.   PLoS One

mTOR couples cellular nutrient sensing to organismal metabolic homeostasis

(2011) Jessica J. Howell et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Perspectives on the role of mTORC2 in B lymphocyte development, immunity and tumorigenesis

(2011) Adam S. Lazorchak et al.   Protein & Cell

Targeting the dysregulated mammalian target of rapamycin pathway in organ transplantation: killing 2 birds with 1 stone

(2011) Michael Haidinger et al.   Transplantation Reviews

Phosphoinositide 3-kinase and the mammalian target of rapamycin pathways control T cell migration

(2010) David Finlay et al.   Annals of the New York Academy of Sciences

Constitutive reductions in mTOR alter cell size, immune cell development, and antibody production

(2010) S. Zhang et al.   BLOOD

Fine-tuning CD8+T-cell functional responses: mTOR acts as a rheostat for regulating CD8+T-cell proliferation, survival and differentiation?

(2010) Rajesh R. Rao et al.   CELL CYCLE

mTOR signalling and metabolic regulation of T cell differentiation

(2010) Christian Peter et al.   CURRENT OPINION IN IMMUNOLOGY

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Mammalian Target of Rapamycin Complex 1 Suppresses Lipolysis, Stimulates Lipogenesis, and Promotes Fat Storage

(2010) P. Chakrabarti et al.   DIABETES

Adenosine 5′-Monophosphate-Activated Protein Kinase-Mammalian Target of Rapamycin Cross Talk Regulates Brown Adipocyte Differentiation

(2010) Rocio Vila-Bedmar et al.   ENDOCRINOLOGY

Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling

(2010) Meidan Goldfinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Single Immunoglobulin Interlukin-1 Receptor-Related Molecule Leads to Enhanced Colonic Polyposis in Apcmin Mice

(2010) Hui Xiao et al.   GASTROENTEROLOGY

Mammalian Target of Rapamycin Controls Dendritic Cell Development Downstream of Flt3 Ligand Signaling

(2010) Taheri Sathaliyawala et al.   IMMUNITY

The Mammalian Target of Rapamycin: Linking T Cell Differentiation, Function, and Metabolism

(2010) Jonathan D. Powell et al.   IMMUNITY

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

(2010) Keunwook Lee et al.   IMMUNITY

The Receptor SIGIRR Suppresses Th17 Cell Proliferation via Inhibition of the Interleukin-1 Receptor Pathway and mTOR Kinase Activation

(2010) Muhammet F. Gulen et al.   IMMUNITY

The mTOR Kinase Determines Effector versus Memory CD8 + T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

(2010) Rajesh R. Rao et al.   IMMUNITY

The role of mTOR in memory CD8+ T-cell differentiation

(2010) Koichi Araki et al.   IMMUNOLOGICAL REVIEWS

Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

(2010) Kathryn G. Foster et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integration of General Amino Acid Control and Target of Rapamycin (TOR) Regulatory Pathways in Nitrogen Assimilation in Yeast

(2010) Kirk A. Staschke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PI3 kinase signalling blocks Foxp3 expression by sequestering Foxo factors: Figure 1.

(2010) Matthias Merkenschlager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Rapamycin Augments Pathogen-Specific but Not Graft-Reactive CD8+ T Cell Responses

(2010) I. R. Ferrer et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Expression of the Transcription Factor E74-Like Factor 4 Is Regulated by the Mammalian Target of Rapamycin Pathway in CD8+ T Cells

(2010) T. Yamada et al.   JOURNAL OF IMMUNOLOGY

A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation

(2010) M. Haidinger et al.   JOURNAL OF IMMUNOLOGY

mTORC1 Inhibition via Rapamycin Promotes Triacylglycerol Lipolysis and Release of Free Fatty Acids in 3T3-L1 Adipocytes

(2010) Ghada A. Soliman et al.   LIPIDS

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

(2010) C A Sparks et al.   ONCOGENE

Everolimus: A Proliferation Signal Inhibitor with Clinical Applications in Organ Transplantation, Oncology, and Cardiology

(2010) Steven Gabardi et al.   PHARMACOTHERAPY

Duration of antigen receptor signaling determines T-cell tolerance or activation

(2010) S. D. Katzman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential effects of STAT5 and PI3K/AKT signaling on effector and memory CD8 T-cell survival

(2010) T. W. Hand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

Efficacy and safety of de novo or early everolimus with low cyclosporine in deceased-donor kidney transplant recipients at specified risk of delayed graft function: 12-month results of a randomized, multicenter trial

(2010) Jacques Dantal et al.   TRANSPLANT INTERNATIONAL

Coordinated control of the gene expression machinery

(2010) Robert J. White et al.   TRENDS IN GENETICS

The Multifunctional Role of mTOR in Innate Immunity: Implications for Transplant Immunity

(2009) M. D. Säemann et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Therapeutic targeting of mTOR in tuberous sclerosis

(2009) Julian R. Sampson   BIOCHEMICAL SOCIETY TRANSACTIONS

A complex interplay between Akt, TSC2 and the two mTOR complexes: Figure 1

(2009) Jingxiang Huang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

(2009) David A. Guertin et al.   CANCER CELL

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

(2009) E.A. Dunlop et al.   CELLULAR SIGNALLING

An Emerging Role of mTOR in Lipid Biosynthesis

(2009) Mathieu Laplante et al.   CURRENT BIOLOGY

Balancing needs and means: the dilemma of the β-cell in the modern world

(2009) G. Leibowitz et al.   DIABETES OBESITY & METABOLISM

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

mTOR: taking cues from the immune microenvironment

(2009) Greg M. Delgoffe et al.   IMMUNOLOGY

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Anergic T Cells Are Metabolically Anergic

(2009) Y. Zheng et al.   JOURNAL OF IMMUNOLOGY

Rosiglitazone-induced heart remodelling is associated with enhanced turnover of myofibrillar protein and mTOR activation

(2009) William T. Festuccia et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

(2009) Erika L. Pearce et al.   NATURE

mTOR regulates memory CD8 T-cell differentiation

(2009) Koichi Araki et al.   NATURE

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

(2008) T Weichhart et al.   ANNALS OF THE RHEUMATIC DISEASES

SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

(2008) Thomas Porstmann et al.   Cell Metabolism

Rapamycin Monotherapy in Patients With Type 1 Diabetes Modifies CD4+CD25+FOXP3+ Regulatory T-Cells

(2008) P. Monti et al.   DIABETES

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

mTOR Inhibition by Rapamycin Prevents  -Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

(2008) M. Fraenkel et al.   DIABETES

Mammalian target of rapamycin (mTOR) orchestrates the defense program of innate immune cells

(2008) Frank Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The TSC-mTOR Signaling Pathway Regulates the Innate Inflammatory Response

(2008) Thomas Weichhart et al.   IMMUNITY

Foxp3 Processing by Proprotein Convertases and Control of Regulatory T Cell Function

(2008) Edwin F. de Zoeten et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

De novo induction of antigen-specific CD4+CD25+Foxp3+ regulatory T cells in vivo following systemic antigen administration accompanied by blockade of mTOR

(2008) Johnthomas Kang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cell Growth Control: mTOR Takes on Fat

(2008) Ted Powers   MOLECULAR CELL

The mammalian target of rapamycin pathway and its role in molecular nutrition regulation

(2008) Jun Lian et al.   MOLECULAR NUTRITION & FOOD RESEARCH

T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR

(2008) S. Sauer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fifteen Years of Clinical Studies and Clinical Practice in Renal Transplantation: Reviewing Outcomes With De Novo Use of Sirolimus in Combination With Cyclosporine

(2008) B.D. Kahan   TRANSPLANTATION PROCEEDINGS