Analysis of single-cell cytokine secretion reveals a role for paracrine signaling in coordinating macrophage responses to TLR4 stimulation

Fold Change of Nuclear NF-κB Determines TNF-Induced Transcription in Single Cells

(2014) Robin E.C. Lee et al.   MOLECULAR CELL

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

(2014) Alex K. Shalek et al.   NATURE

The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells

(2014) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Single-cell technologies for monitoring immune systems

(2014) Pratip K Chattopadhyay et al.   NATURE IMMUNOLOGY

Secreting and Sensing the Same Molecule Allows Cells to Achieve Versatile Social Behaviors

(2014) H. Youk et al.   SCIENCE

Switching of the Relative Dominance Between Feedback Mechanisms in Lipopolysaccharide-Induced NF- B Signaling

(2014) M.-H. Sung et al.   Science Signaling

High-Throughput Secretomic Analysis of Single Cells to Assess Functional Cellular Heterogeneity

(2013) Yao Lu et al.   ANALYTICAL CHEMISTRY

Anatomically Restricted Synergistic Antiviral Activities of Innate and Adaptive Immune Cells in the Skin

(2013) Heather D. Hickman et al.   Cell Host & Microbe

IL-1  Promotes Antimicrobial Immunity in Macrophages by Regulating TNFR Signaling and Caspase-3 Activation

(2013) P. Jayaraman et al.   JOURNAL OF IMMUNOLOGY

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Nod2-Induced Autocrine Interleukin-1 Alters Signaling by ERK and p38 to Differentially Regulate Secretion of Inflammatory Cytokines

(2012) Matija Hedl et al.   GASTROENTEROLOGY

IL-6 Amplifier, NF- B-Triggered Positive Feedback for IL-6 Signaling, in Grafts Is Involved in Allogeneic Rejection Responses

(2012) J. Lee et al.   JOURNAL OF IMMUNOLOGY

Inhibition of JAKs in Macrophages Increases Lipopolysaccharide-Induced Cytokine Production by Blocking IL-10-Mediated Feedback

(2012) M. J. Pattison et al.   JOURNAL OF IMMUNOLOGY

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response

(2012) Ulfert Rand et al.   Molecular Systems Biology

Predictive microfluidic control of regulatory ligand trajectories in individual pluripotent cells

(2012) F. Moledina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-10-induced microRNA-187 negatively regulates TNF- , IL-6, and IL-12p40 production in TLR4-stimulated monocytes

(2012) M. Rossato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stochastic Expression of the Interferon-β Gene

(2012) Mingwei Zhao et al.   PLOS BIOLOGY

Distinct Roles for Nod2 Protein and Autocrine Interleukin-1β in Muramyl Dipeptide-induced Mitogen-activated Protein Kinase Activation and Cytokine Secretion in Human Macrophages

(2011) Matija Hedl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

A clinical microchip for evaluation of single immune cells reveals high functional heterogeneity in phenotypically similar T cells

(2011) Chao Ma et al.   NATURE MEDICINE

Polyfunctional responses by human T cells result from sequential release of cytokines

(2011) Q. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Secretory Mediators Regulate Nod2-Induced Tolerance in Human Macrophages

(2010) Matija Hedl et al.   GASTROENTEROLOGY

Patterns of basal signaling heterogeneity can distinguish cellular populations with different drug sensitivities

(2010) Dinesh Kumar Singh et al.   Molecular Systems Biology

Short-term memory in gene induction reveals the regulatory principle behind stochastic IL-4 expression

(2010) Luca Mariani et al.   Molecular Systems Biology

Population robustness arising from cellular heterogeneity

(2010) P. Paszek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection

(2010) F. S. Garmaroudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Adaptive Immunity by the Innate Immune System

(2010) A. Iwasaki et al.   SCIENCE

On-Chip Activation and Subsequent Detection of Individual Antigen-Specific T Cells

(2009) Qing Song et al.   ANALYTICAL CHEMISTRY

Population context determines cell-to-cell variability in endocytosis and virus infection

(2009) Berend Snijder et al.   NATURE

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis

(2009) Sabrina L. Spencer et al.   NATURE

A Noisy Paracrine Signal Determines the Cellular NF- B Response to Lipopolysaccharide

(2009) T. K. Lee et al.   Science Signaling

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

TNF -induced GM-CSF release from human airway smooth muscle cells depends on activation of an ET-1 autoregulatory positive feedback mechanism

(2009) J Knobloch et al.   THORAX

Determining biological noise via single cell analysis

(2008) Edgar A. Arriaga   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Interleukin-17 Promotes Autoimmunity by Triggering a Positive-Feedback Loop via Interleukin-6 Induction

(2008) Hideki Ogura et al.   IMMUNITY

Transcriptome-wide noise controls lineage choice in mammalian progenitor cells

(2008) Hannah H. Chang et al.   NATURE