Loss of FTO in adipose tissue decreasesAngptl4translation and alters triglyceride metabolism

Circadian rhythm of RNA N6-methyladenosine and the role of cryptochrome

(2015) Chao-Yung Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

(2015) Melina Claussnitzer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

(2015) Rocio Vila-Bedmar et al.   Science Signaling

FTO influences adipogenesis by regulating mitotic clonal expansion

(2015) Myrte Merkestein et al.   Nature Communications

Reversal of diet-induced obesity and insulin resistance by inducible genetic ablation of GRK2

(2015) Rocio Vila-Bedmar et al.   Science Signaling

FTO is necessary for the induction of leptin resistance by high-fat feeding

(2015) Y.C. Loraine Tung et al.   Molecular Metabolism

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

Hypomorphism for RPGRIP1L, a Ciliary Gene Vicinal to the FTO Locus, Causes Increased Adiposity in Mice

(2014) George Stratigopoulos et al.   Cell Metabolism

FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis

(2014) Xu Zhao et al.   CELL RESEARCH

Fat mass and obesity-associated (FTO) protein interacts with CaMKII and modulates the activity of CREB signaling pathway

(2014) L. Lin et al.   HUMAN MOLECULAR GENETICS

Obesity-associated variants within FTO form long-range functional connections with IRX3

(2014) Scott Smemo et al.   NATURE

Regulation of lipoprotein lipase by Angptl4

(2014) Wieneke Dijk et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

(2013) Jean-Michel Fustin et al.   CELL

FTO Deficiency Induces UCP-1 Expression and Mitochondrial Uncoupling in Adipocytes

(2013) D. Tews et al.   ENDOCRINOLOGY

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance

(2013) Chong Wee Liew et al.   NATURE MEDICINE

Role for the obesity-related FTO gene in the cellular sensing of amino acids

(2013) P. Gulati et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adult Onset Global Loss of the Fto Gene Alters Body Composition and Metabolism in the Mouse

(2013) Fiona McMurray et al.   PLoS Genetics

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes

(2012) Nora E. Gray et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FTO genotype is associated with phenotypic variability of body mass index

(2012) Jian Yang et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Angiopoietin-like 4: a decade of research

(2011) Pengcheng Zhu et al.   BIOSCIENCE REPORTS

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

New wrinkles in lipoprotein lipase biology

(2011) Brandon S.J. Davies et al.   CURRENT OPINION IN LIPIDOLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

Fto immunoreactivity is widespread in the rodent brain and abundant in feeding-related sites, but the number of Fto-positive cells is not affected by changes in energy balance

(2011) Pawel K. Olszewski et al.   PHYSIOLOGY & BEHAVIOR

Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages

(2010) Laeticia Lichtenstein et al.   Cell Metabolism

Hypothalamic Angptl4/Fiaf Is a Novel Regulator of Food Intake and Body Weight

(2010) H.-K. Kim et al.   DIABETES

Current concepts in triglyceride metabolism, pathophysiology, and treatment

(2010) Georges AbouRjaili et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FTO gains function

(2010) George Stratigopoulos et al.   NATURE GENETICS

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS

Podocyte-secreted angiopoietin-like-4 mediates proteinuria in glucocorticoid-sensitive nephrotic syndrome

(2010) Lionel C Clement et al.   NATURE MEDICINE

The Fat Mass and Obesity Associated Gene FTO Functions in the Brain to Regulate Postnatal Growth in Mice

(2010) Xue Gao et al.   PLoS One

Loss-of-Function Mutation in the Dioxygenase-Encoding FTO Gene Causes Severe Growth Retardation and Multiple Malformations

(2009) Sarah Boissel et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lipoprotein lipase: from gene to obesity

(2009) Hong Wang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids

(2009) Sander Kersten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

FTO – Friend or Foe?

(2009) D. Tews et al.   HORMONE AND METABOLIC RESEARCH

Inactivation of the Fto gene protects from obesity

(2009) Julia Fischer et al.   NATURE

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

(2009) C.-Y. Wang et al.   Science Signaling

A Mouse Model for the Metabolic Effects of the Human Fat Mass and Obesity Associated FTO Gene

(2009) Chris Church et al.   PLoS Genetics

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH