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The effects of early life stress on the epigenome: From the womb to adulthood and even before

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FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications

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Antidepressant-Like Effect of Sodium Butyrate is Associated with an Increase in TET1 and in 5-Hydroxymethylation Levels in the Bdnf Gene

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(2014) Martin J. Aryee et al.   BIOINFORMATICS

A Quantitative Chaperone Interaction Network Reveals the Architecture of Cellular Protein Homeostasis Pathways

(2014) Mikko Taipale et al.   CELL

Selective inhibitors of the FK506-binding protein 51 by induced fit

(2014) Steffen Gaali et al.   Nature Chemical Biology

Tet oxidizes thymine to 5-hydroxymethyluracil in mouse embryonic stem cell DNA

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HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

(2014) Luke Whitesell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of FKBP51 with Priming of Autophagy Pathways and Mediation of Antidepressant Treatment Response: Evidence in Cells, Mice, and Humans

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Epigenetic Mechanisms of Depression

(2014) Eric J. Nestler   JAMA Psychiatry

Discovery of cross-reactive probes and polymorphic CpGs in the Illumina Infinium HumanMethylation450 microarray

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Methylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression

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Childhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder

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Cryptic Variation in Morphological Evolution: HSP90 as a Capacitor for Loss of Eyes in Cavefish

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Additional annotation enhances potential for biologically-relevant analysis of the Illumina Infinium HumanMethylation450 BeadChip array

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Epigenetic Risk Factors in PTSD and Depression

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Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels

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An insight into the various regulatory mechanisms modulating human DNA methyltransferase 1 stability and function

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Gene × environment interactions in the prediction of response to antidepressant treatment

(2012) Torsten Klengel et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Dexamethasone Stimulated Gene Expression in Peripheral Blood is a Sensitive Marker for Glucocorticoid Receptor Resistance in Depressed Patients

(2012) Andreas Menke et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic Mechanisms of Depression and Antidepressant Action

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FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

(2011) Chadi Touma et al.   BIOLOGICAL PSYCHIATRY

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Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors

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Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

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The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

AGNP Consensus Guidelines for Therapeutic Drug Monitoring in Psychiatry: Update 2011

(2011) C. Hiemke et al.   PHARMACOPSYCHIATRY

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

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(2011) Joao P. Lopes et al.   PROGRESS IN NEUROBIOLOGY

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Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis

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Chronic Corticosterone Exposure Increases Expression and Decreases Deoxyribonucleic Acid Methylation ofFkbp5in Mice

(2010) Richard S. Lee et al.   ENDOCRINOLOGY

Glucocorticoids, prenatal stress and the programming of disease

(2010) Anjanette Harris et al.   HORMONES AND BEHAVIOR

Subcellular rearrangement of hsp90-binding immunophilins accompanies neuronal differentiation and neurite outgrowth

(2010) Héctor R. Quintá et al.   JOURNAL OF NEUROCHEMISTRY

The Hsp90 Cochaperone, FKBP51, Increases Tau Stability and Polymerizes Microtubules

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Genome-wide RNAi screens in bloodstream form trypanosomes identify drug transporters

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Glucocorticoid Receptor Activates PoisedFKBP51Locus through Long-Distance Interactions

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Interaction of FKBP5, a Stress-Related Gene, with Childhood Trauma Increases the Risk for Attempting Suicide

(2010) Alec Roy et al.   NEUROPSYCHOPHARMACOLOGY

Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders

(2010) Yan-Feng Zou et al.   NEUROSCIENCE LETTERS

Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors

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Hsp90 and Environmental Stress Transform the Adaptive Value of Natural Genetic Variation

(2010) D. F. Jarosz et al.   SCIENCE

FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

(2009) Huadong Pei et al.   CANCER CELL

Trauma exposure and stress-related disorders in inner city primary care patients

(2009) Charles F. Gillespie et al.   GENERAL HOSPITAL PSYCHIATRY

Valproate and Amitriptyline Exert Common and Divergent Influences on Global and Gene Promoter-Specific Chromatin Modifications in Rat Primary Astrocytes

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Pharmacogenetics Studies in STAR*D: Strengths, Limitations, and Results

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The FKBP5-Gene in Depression and Treatment Response—an Association Study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort

(2008) Magnus Lekman et al.   BIOLOGICAL PSYCHIATRY

Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

(2008) Elisabeth B. Binder   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Epigenetic Regulation of bdnf Gene Transcription in the Consolidation of Fear Memory

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Clinical characteristics and treatment outcome in a representative sample of depressed inpatients – Findings from the Munich Antidepressant Response Signature (MARS) project

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Inhibition of Histone Deacetylases Promotes Ubiquitin-Dependent Proteasomal Degradation of DNA Methyltransferase 1 in Human Breast Cancer Cells

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