Melatonin attenuates sepsis-induced cardiac dysfunction via a PI3K/Akt-dependent mechanism

Ginsenoside Rd promotes neurogenesis in rat brain after transient focal cerebral ischemia via activation of PI3K/Akt pathway

(2015) Xin-yu Liu et al.   ACTA PHARMACOLOGICA SINICA

Reduction of no-reflow and reperfusion injury with the synthetic 17β-aminoestrogen compound Prolame is associated with PI3K/Akt/eNOS signaling cascade

(2015) Sauri Hernández-Reséndiz et al.   BASIC RESEARCH IN CARDIOLOGY

ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes

(2015) Ji Hyun Jang et al.   BASIC RESEARCH IN CARDIOLOGY

Gliptin and GLP‐1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide‐induced endotoxemia

(2015) Sebastian Steven et al.   BASIC RESEARCH IN CARDIOLOGY

Heparin inhibits the inflammatory response induced by LPS and HMGB1 by blocking the binding of HMGB1 to the surface of macrophages

(2015) Li Li et al.   CYTOKINE

Tyrosine kinase inhibitor tyrphostin AG490 reduces liver injury in LPS-induced shock

(2015) Valeriya Gyurkovska et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Melatonin ameliorates metabolic risk factors, modulates apoptotic proteins, and protects the rat heart against diabetes-induced apoptosis

(2015) Ali H. Amin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effect of melatonin against myocardial injury induced by epinephrine

(2015) Rastislav Vazan et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Mechanisms of isoproterenol-induced cardiac mitochondrial damage: protective actions of melatonin

(2015) Debasri Mukherjee et al.   JOURNAL OF PINEAL RESEARCH

Melatonin uptake through glucose transporters: a new target for melatonin inhibition of cancer

(2015) David Hevia et al.   JOURNAL OF PINEAL RESEARCH

Cortistatin protects myocardium from endoplasmic reticulum stress induced apoptosis during sepsis

(2015) Bo Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Influence of severity of illness on neutrophil gelatinase-associated lipocalin performance as a marker of acute kidney injury: a prospective cohort study of patients with sepsis

(2015) Jill Vanmassenhove et al.   BMC Nephrology

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of p38, Akt, and NF-κB pathways

(2014) Gan Chen et al.   AMINO ACIDS

Overexpression of the muscle-specific protein, melusin, protects from cardiac ischemia/reperfusion injury

(2014) Claudia Penna et al.   BASIC RESEARCH IN CARDIOLOGY

Energy crisis: The role of oxidative phosphorylation in acute inflammation and sepsis

(2014) Icksoo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhalation of hydrogen gas attenuates brain injury in mice with cecal ligation and puncture via inhibiting neuroinflammation, oxidative stress and neuronal apoptosis

(2014) Lingling Liu et al.   BRAIN RESEARCH

Myocardial depression in sepsis: From pathogenesis to clinical manifestations and treatment

(2014) Elio Antonucci et al.   JOURNAL OF CRITICAL CARE

Melatonin reduces cardiac morbidity and markers of myocardial ischemia after elective abdominal aortic aneurism repair: a randomized, placebo-controlled, clinical trial

(2014) Ismail Gögenur et al.   JOURNAL OF PINEAL RESEARCH

Melatonin prevents cell death and mitochondrial dysfunction via a SIRT1-dependent mechanism during ischemic-stroke in mice

(2014) Yang Yang et al.   JOURNAL OF PINEAL RESEARCH

Additional benefit of combined therapy with melatonin and apoptotic adipose-derived mesenchymal stem cell against sepsis-induced kidney injury

(2014) Hong-Hwa Chen et al.   JOURNAL OF PINEAL RESEARCH

Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1

(2014) Liming Yu et al.   JOURNAL OF PINEAL RESEARCH

Cardioprotective effects of melatonin against myocardial injuries induced by chronic intermittent hypoxia in rats

(2014) Hang-Mee Yeung et al.   JOURNAL OF PINEAL RESEARCH

Protective effects of melatonin in reducing oxidative stress and in preserving the fluidity of biological membranes: a review

(2014) Joaquín J. García et al.   JOURNAL OF PINEAL RESEARCH

Melatonin: a well-documented antioxidant with conditional pro-oxidant actions

(2014) Hong-Mei Zhang et al.   JOURNAL OF PINEAL RESEARCH

Redox State of Pentraxin 3 as a Novel Biomarker for Resolution of Inflammation and Survival in Sepsis

(2014) Friederike Cuello et al.   MOLECULAR & CELLULAR PROTEOMICS

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway

(2014) Liufeng Mao et al.   Cell and Bioscience

HMGB1 in severe soft tissue infections caused by Streptococcus pyogenes

(2014) Linda Johansson et al.   Frontiers in Cellular and Infection Microbiology

Melatonin acts through MT1/MT2 receptors to activate hypothalamic Akt and suppress hepatic gluconeogenesis in rats

(2013) Juliana A. Faria et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Endothelial NOS (NOS3) impairs myocardial function in developing sepsis

(2013) Annette M. Sandt et al.   BASIC RESEARCH IN CARDIOLOGY

Melatonin Receptors Mediate Improvements of Survival in a Model of Polymicrobial Sepsis

(2013) Tobias Fink et al.   CRITICAL CARE MEDICINE

α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism

(2013) Surong Jiang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Distinct effects of Nampt inhibition on mild and severe models of lipopolysaccharide-induced myocardial impairment

(2013) Ling Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The Toll-like Receptor 9 Ligand, CpG Oligodeoxynucleotide, Attenuates Cardiac Dysfunction in Polymicrobial Sepsis, Involving Activation of Both Phosphoinositide 3 Kinase/Akt and Extracellular-Signal-Related Kinase Signaling

(2013) Ming Gao et al.   JOURNAL OF INFECTIOUS DISEASES

Stimulation of the α7 Nicotinic Acetylcholine Receptor Protects Against Sepsis by Inhibiting Toll-like Receptor via Phosphoinositide 3-Kinase Activation

(2013) Tae-Hoon Kim et al.   JOURNAL OF INFECTIOUS DISEASES

The beneficial effects of melatonin against heart mitochondrial impairment during sepsis: inhibition of iNOS and preservation of nNOS

(2013) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Inhibition of Na/K-ATPase promotes myocardial tumor necrosis factor-alpha protein expression and cardiac dysfunction via calcium/mTOR signaling in endotoxemia

(2012) Ting Zhang et al.   BASIC RESEARCH IN CARDIOLOGY

Notoginsenoside R1 attenuates cardiac dysfunction in endotoxemic mice: an insight into oestrogen receptor activation and PI3K/Akt signalling

(2012) Bing Sun et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antioxidant potential of different melatonin-loaded nanomedicines in an experimental model of sepsis

(2012) Giovanni Li Volti et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Melatonin prevents hemorrhagic shock-induced liver injury in rats through an Akt-dependent HO-1 pathway

(2012) Jun-Te Hsu et al.   JOURNAL OF PINEAL RESEARCH

Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats

(2012) Ahmad Agil et al.   JOURNAL OF PINEAL RESEARCH

A review of the molecular aspects of melatonin’s anti-inflammatory actions: recent insights and new perspectives

(2012) José L. Mauriz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin improved rat cardiac mitochondria and survival rate in septic heart injury

(2012) Hongmin Zhang et al.   JOURNAL OF PINEAL RESEARCH

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

(2012) Helena Erlandsson Harris et al.   Nature Reviews Rheumatology

Activation of Myocardial Phosphoinositide-3-Kinase p110α Ameliorates Cardiac Dysfunction and Improves Survival in Polymicrobial Sepsis

(2012) Chuanfu Li et al.   PLoS One

Identification of Cardiac Dysfunction in Sepsis with B-Type Natriuretic Peptide

(2011) Krista L. Turner et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

Mitochondrial Nitric Oxide Synthase Participates in Septic Shock Myocardial Depression by Nitric Oxide Overproduction and Mitochondrial Permeability Transition Pore Opening

(2011) Ce Xu et al.   SHOCK

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

(2010) Russell S. Whelan et al.   Annual Review of Physiology

Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3K-dependent mechanism

(2010) H. Zhou et al.   CARDIOVASCULAR RESEARCH

Activation of Akt/GSK-3β signaling pathway is involved in intermedin1-53 protection against myocardial apoptosis induced by ischemia/reperfusion

(2009) Jun-Qiu Song et al.   APOPTOSIS

Melatonin: Signaling mechanisms of a pleiotropic agent

(2009) Rüdiger Hardeland   BIOFACTORS

Amlodipine inhibits TNF-α production and attenuates cardiac dysfunction induced by lipopolysaccharide involving PI3K/Akt pathway

(2009) Xiao-Qiang Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

CARDIAC-SPECIFIC EXPRESSION OF HEAT SHOCK PROTEIN 27 ATTENUATED ENDOTOXIN-INDUCED CARDIAC DYSFUNCTION AND MORTALITY IN MICE THROUGH A PI3K/AKT-DEPENDENT MECHANISM

(2009) Wenjun You et al.   SHOCK

Ischemia-reperfusion injury and cardioprotection: investigating PTEN, the phosphatase that negatively regulates PI3K, using a congenital model of PTEN haploinsufficiency

(2008) Hilary K. Siddall et al.   BASIC RESEARCH IN CARDIOLOGY

Ischemic Postconditioning in Pigs

(2008) Andreas Skyschally et al.   CIRCULATION RESEARCH

Therapeutic effects of melatonin on peritonitis-induced septic shock with multiple organ dysfunction syndrome in rats

(2008) Jeng-Yuan Wu et al.   JOURNAL OF PINEAL RESEARCH

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(2008) John Klune et al.   MOLECULAR MEDICINE

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS