Emerging role of liver X receptors in cardiac pathophysiology and heart failure

Liver X receptor activation enhances CVB3 viral replication during myocarditis by stimulating lipogenesis

(2015) Anna-Pia Papageorgiou et al.   CARDIOVASCULAR RESEARCH

Are There Genetic Paths Common to Obesity, Cardiovascular Disease Outcomes, and Cardiovascular Risk Factors?

(2015) T. Rankinen et al.   CIRCULATION RESEARCH

Cardiac LXR  protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization

(2015) M. V. Cannon et al.   EMBO Molecular Medicine

The liver X receptor agonist AZ876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects

(2015) Megan V. Cannon et al.   EUROPEAN JOURNAL OF HEART FAILURE

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

(2014) Qing He et al.   Cardiovascular Diabetology

Broad-Spectrum Therapeutic Suppression of Metastatic Melanoma through Nuclear Hormone Receptor Activation

(2014) Nora Pencheva et al.   CELL

Insulin-Sensitizing Effect of LXR Agonist T0901317 in High-Fat Fed Rats is Associated with Restored Muscle GLUT4 Expression and Insulin-Stimulated AS160 Phosphorylation

(2014) Marcin Baranowski et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Heart Failure With Preserved Ejection Fraction

(2014) Kavita Sharma et al.   CIRCULATION RESEARCH

Activation of Liver-X-Receptor α But Not Liver-X-Receptor β Protects Against Myocardial Ischemia/Reperfusion Injury

(2014) Qing He et al.   Circulation-Heart Failure

Association Between Use of β-Blockers and Outcomes in Patients With Heart Failure and Preserved Ejection Fraction

(2014) Lars H. Lund et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Cardiovascular remodelling in coronary artery disease and heart failure

(2014) Gerd Heusch et al.   LANCET

Association of liver X receptor α (LXRα) gene polymorphism and coronary heart disease, serum lipids and glucose levels

(2014) Yun-Fei Zhou et al.   Lipids in Health and Disease

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

A Liver-X-Receptor Ligand, T0901317, Attenuates IgE Production and Airway Remodeling in Chronic Asthma Model of Mice

(2014) Ying Shi et al.   PLoS One

Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes

(2014) T. Hayashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of liver X receptor enhances the proliferation and migration of endothelial progenitor cells and promotes vascular repair through PI3K/Akt/eNOS signaling pathway activation

(2014) Jie Yu et al.   VASCULAR PHARMACOLOGY

Synthetic liver X receptor agonist T0901317 attenuates high glucose-induced oxidative stress, mitochondrial damage and apoptosis in cardiomyocytes

(2013) Yongxia Cheng et al.   ACTA HISTOCHEMICA

Lipid Droplet Accumulation Is Associated with an Increase in Hyperglycemia-Induced Renal Damage

(2013) Eva Kiss et al.   AMERICAN JOURNAL OF PATHOLOGY

Activation of Liver X Receptor Decreases Atherosclerosis in Ldlr −/− Mice in the Absence of ATP-Binding Cassette Transporters A1 and G1 in Myeloid Cells

(2013) Mojdeh S. Kappus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LXR agonism improves TNF-α-induced endothelial dysfunction in the absence of its cholesterol-modulating effects

(2013) Frank Spillmann et al.   ATHEROSCLEROSIS

Reciprocal Regulation of Hepatic and Adipose Lipogenesis by Liver X Receptors in Obesity and Insulin Resistance

(2013) Simon W. Beaven et al.   Cell Metabolism

Pathological Ventricular Remodeling

(2013) Jana S. Burchfield et al.   CIRCULATION

Heart Disease and Stroke Statistics—2014 Update

(2013) Alan S. Go et al.   CIRCULATION

Liver X Receptor Activation Stimulates Iron Export in Human Alternative Macrophages

(2013) Gaël Bories et al.   CIRCULATION RESEARCH

Liver X receptors preserve renal glomerular integrity under normoglycaemia and in diabetes in mice

(2013) Monika Patel et al.   DIABETOLOGIA

Incidence and epidemiology of new onset heart failure with preserved vs. reduced ejection fraction in a community-based cohort: 11-year follow-up of PREVEND

(2013) F. P. Brouwers et al.   EUROPEAN HEART JOURNAL

Oxysterol receptors and their therapeutic applications in cancer conditions

(2013) Hugues De Boussac et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Lack of association between LXRα and LXRβ gene polymorphisms and prevalence of metabolic syndrome: A case–control study of an Iranian population

(2013) Hassan Rooki et al.   GENE

A Novel Paradigm for Heart Failure With Preserved Ejection Fraction

(2013) Walter J. Paulus et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Control of angiogenesis by AIBP-mediated cholesterol efflux

(2013) Longhou Fang et al.   NATURE

Inflammation and metabolic dysfunction: links to cardiovascular diseases

(2012) Annika Taube et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Liver X Receptor Activation Reduces Angiogenesis by Impairing Lipid Raft Localization and Signaling of Vascular Endothelial Growth Factor Receptor-2

(2012) Alessio Noghero et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of Liver X receptors in the heart leads to accumulation of intracellular lipids and attenuation of ischemia–reperfusion injury

(2012) Peng Lei et al.   BASIC RESEARCH IN CARDIOLOGY

Liver X Receptor Modulates Diabetic Retinopathy Outcome in a Mouse Model of Streptozotocin-Induced Diabetes

(2012) S. Hazra et al.   DIABETES

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC

(2012) et al.   EUROPEAN HEART JOURNAL

Liver X receptor activation attenuates plaque formation and improves vasomotor function of the aortic artery in atherosclerotic ApoE−/− mice

(2012) Jianghong Chen et al.   INFLAMMATION RESEARCH

Association Between Use of Renin-Angiotensin System Antagonists and Mortality in Patients With Heart Failure and Preserved Ejection Fraction

(2012) Lars H. Lund et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice

(2012) Yuan Zhang et al.   JOURNAL OF CLINICAL INVESTIGATION

Activation of Liver X Receptor Inhibits Osteopontin and Ameliorates Diabetic Nephropathy

(2012) H. Tachibana et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms and Treatment of CKD

(2012) P. Ruggenenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Liver X Receptor Agonist Alleviated High Glucose-Induced Endothelial Progenitor Cell Dysfunction via Inhibition of Reactive Oxygen Species and Activation of AMP-Activated Protein Kinase

(2012) XIAOXIA LI et al.   MICROCIRCULATION

Central diabetes insipidus associated with impaired renal aquaporin-1 expression in mice lacking liver X receptor  

(2012) C. Gabbi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Liver X receptor biology and pharmacology: new pathways, challenges and opportunities

(2012) Tomas Jakobsson et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Genetic Variation in Liver X Receptor Alpha and Risk of Ischemic Vascular Disease in the General Population

(2011) Stefan Stender et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting fatty acid and carbohydrate oxidation — A novel therapeutic intervention in the ischemic and failing heart

(2011) Jagdip S. Jaswal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LXR as a novel antithrombotic target

(2011) M. Spyridon et al.   BLOOD

Optimization of Cardiac Metabolism in Heart Failure

(2011) Tomohisa Nagoshi et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting liver X receptors in human health: deadlock or promising trail?

(2011) Emilie Viennois et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR−/− mice

(2011) G Li et al.   GENE THERAPY

Liver X Receptor Signaling Pathways and Atherosclerosis

(2010) Anna C. Calkin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

LXR activation inhibits chemokine-induced CD4-positive lymphocyte migration

(2010) Daniel Walcher et al.   BASIC RESEARCH IN CARDIOLOGY

Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe)

(2010) Karianne Solaas et al.   BMC Medical Genetics

Cardiac Inflammation Contributes to Changes in the Extracellular Matrix in Patients With Heart Failure and Normal Ejection Fraction

(2010) Dirk Westermann et al.   Circulation-Heart Failure

Activation of liver X receptors with T0901317 attenuates cardiac hypertrophyin vivo

(2010) Irma Kuipers et al.   EUROPEAN JOURNAL OF HEART FAILURE

Liver X Receptor Signaling Is a Determinant of Stellate Cell Activation and Susceptibility to Fibrotic Liver Disease

(2010) Simon W. Beaven et al.   GASTROENTEROLOGY

Elevated Expression of Liver X Receptor Alpha (LXRα) in Myocardium of Streptozotocin-Induced Diabetic Rats

(2010) Yongxia Cheng et al.   INFLAMMATION

Liver X Receptor (LXR) Regulates Human Adipocyte Lipolysis

(2010) Britta M. Stenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transforming growth factor (TGF)-β signaling in cardiac remodeling

(2010) Marcin Dobaczewski et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic variation within the NR1H2 gene encoding liver X receptor β associates with insulin secretion in subjects at increased risk for type 2 diabetes

(2010) Caroline Ketterer et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Activation of liver X receptor-α reduces activation of the renal and cardiac renin–angiotensin–aldosterone system

(2010) Irma Kuipers et al.   LABORATORY INVESTIGATION

Activation of liver X receptor reduces global ischemic brain injury by reduction of nuclear factor-κB

(2010) O. Cheng et al.   NEUROSCIENCE

Both liver-X receptor (LXR) isoforms control energy expenditure by regulating Brown Adipose Tissue activity

(2010) M. Korach-Andre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Separate and overlapping metabolic functions of LXRα and LXRβ in C57Bl/6 female mice

(2009) Marion Korach-André et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Liver X receptors are negative regulators of cardiac hypertrophy via suppressing NF- B signalling

(2009) S. Wu et al.   CARDIOVASCULAR RESEARCH

Induction of Transglutaminase 2 by a Liver X Receptor/Retinoic Acid Receptor α Pathway Increases the Clearance of Apoptotic Cells by Human Macrophages

(2009) Cédric Rébé et al.   CIRCULATION RESEARCH

Apoptotic Cells Promote Their Own Clearance and Immune Tolerance through Activation of the Nuclear Receptor LXR

(2009) Noelia A-Gonzalez et al.   IMMUNITY

Activation of the Liver X Receptor Prevents Lipopolysaccharide-induced Lung Injury

(2009) Haibiao Gong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

c-Jun N-Terminal Kinase 1/2 Activation by Tumor Necrosis Factor-α Induces Insulin Resistance In Human Visceral But Not Subcutaneous Adipocytes: Reversal by Liver X Receptor Agonists

(2009) Sonia Fernández-Veledo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Safety, Pharmacokinetics, and Pharmacodynamics of Single Doses of LXR-623, a Novel Liver X-Receptor Agonist, in Healthy Participants

(2009) Arie Katz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Liver X receptor agonist treatment reduced splanchnic ischemia and reperfusion injury

(2009) Concetta Crisafulli et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Functional genomics of blood cellular LXR-α gene in human coronary heart disease

(2009) Vivek P. Dave et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Adrenergic-Fatty Acid Load in Heart Failure

(2009) Lionel H. Opie et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

eNOS Mediates TO90317 Treatment-Induced Angiogenesis and Functional Outcome After Stroke in Mice

(2009) Jieli Chen et al.   STROKE

LXR Signaling Couples Sterol Metabolism to Proliferation in the Acquired Immune Response

(2008) Steven J. Bensinger et al.   CELL

Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest

(2008) Z. X. Meng et al.   DIABETOLOGIA

Heart failure with preserved ejection fraction: Clinical characteristics of 4133 patients enrolled in the I-PRESERVE trial

(2008) John J.V. McMurray et al.   EUROPEAN JOURNAL OF HEART FAILURE

Treatment with LXR agonists after focal cerebral ischemia prevents brain damage

(2008) Luigi Sironi et al.   FEBS LETTERS

Liver X Receptor Activator Downregulates Angiotensin II Type 1 Receptor Expression Through Dephosphorylation of Sp1

(2008) Ikuyo Imayama et al.   HYPERTENSION

Association between liver X receptor α gene polymorphisms and risk of metabolic syndrome in French populations

(2008) V Legry et al.   INTERNATIONAL JOURNAL OF OBESITY

RAP250 Is a Coactivator in the Transforming Growth Factor β Signaling Pathway That Interacts with Smad2 and Smad3

(2008) Per Antonson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LXR agonist suppresses atherosclerotic lesion growth and promotes lesion regression in apoE*3Leiden mice: time course and mechanisms

(2008) Lars Verschuren et al.   JOURNAL OF LIPID RESEARCH

Insulin-Resistant Cardiomyopathy

(2008) Ronald M. Witteles et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Defining human diabetic nephropathy on the molecular level: Integration of transcriptomic profiles with biological knowledge

(2008) Sebastian Martini et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

Laminar Shear Stress Regulates Liver X Receptor in Vascular Endothelial Cells

(2007) Minjia Zhu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GW3965, a synthetic liver X receptor (LXR) agonist, reduces angiotensin II-mediated pressor responses in Sprague-Dawley rats

(2007) C E Leik et al.   BRITISH JOURNAL OF PHARMACOLOGY