Article
Chemistry, Medicinal
Qi Zhang, Yue Shen, Sayeman Islam Niloy, Stephen T. O'Rourke, Chengwen Sun
Summary: This study found that chronic infusion of apelin-13 does not change blood pressure or heart rate, and does not alter Ang II-induced hypertension and cardiac hypertrophy. These findings suggest that an APJ receptor biased agonist could be a better therapeutic alternative for treatment of hypertension.
Article
Peripheral Vascular Disease
Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund
Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.
Article
Cardiac & Cardiovascular Systems
Rasmus Dreier, Ulrik B. Andersen, Julie L. Forman, Majid Sheykhzade, Martin Egfjord, Jorgen L. Jeppesen
Summary: Increasing potassium intake raises plasma potassium and aldosterone levels, potentiating AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Nirupama Ramkumar, Deborah Stuart, Caitlin S. Peterson, Chunyan Hu, William Wheatley, Jae Min Cho, J. David Symons, Donald E. Kohan
Summary: Loss of sPRR reduces baseline blood pressure, decreases Ang II-induced hypertension and renal injury, and is associated with greater endothelium-dependent vasorelaxation of resistance-sized arteries.
CIRCULATION RESEARCH
(2021)
Article
Peripheral Vascular Disease
Zhennan Lin, Xinyan Wang, Fangchao Liu, Xueli Yang, Qiong Liu, Xiaolong Xing, Jie Cao, Jianxin Li, Keyong Huang, Weili Yan, Tingting Liu, Meng Fan, Wei Li, Shufeng Chen, Xiangfeng Lu, Dongfeng Gu, Jianfeng Huang
Summary: Short-term exposure to PM2.5 has adverse effects on blood pressure, but these effects are attenuated in patients with controlled blood pressure. Among those with uncontrolled blood pressure, the use of angiotensin receptor blockers may potentially lower blood pressure in response to PM2.5 exposure.
Article
Biochemistry & Molecular Biology
Shan Jiang, Yongjie Shui, Yu Cui, Chun Tang, Xiaohua Wang, Xingyu Qiu, Weipeng Hu, Lingyan Fei, Yun Li, Suping Zhang, Liang Zhao, Nan Xu, Fang Dong, Xiaoqiu Ren, Ruisheng Liu, Pontus B. Persson, Andreas Patzak, En Yin Lai, Qichun Wei, Zhihua Zheng
Summary: The study revealed that TMAO can enhance Ang II-induced hypertension and mediate Ang II-induced vasoconstriction, possibly through the PERK/ROS/CaMKII/PLC beta 3 pathway.
Article
Cell Biology
Vanessa Oliveira, Ruth A. Riedl, Kristin E. Claflin, Natalia M. Mathieu, McKenzie L. Ritter, Kirthikaa Balapattabi, Kelsey K. Wackman, John J. Reho, Daniel T. Brozoski, Donald A. Morgan, Huxing Cui, Kamal Rahmouni, Colin M. L. Burnett, Pablo Nakagawa, Curt D. Sigmund, Lisa L. Morselli, Justin L. Grobe
Summary: The brain renin-angiotensin system plays a role in the regulation of blood pressure, fluid intake, and energy expenditure. Leptin and angiotensin II in the brain stimulate energy expenditure through a shared mechanism. The metabolic effects of leptin depend on MC4R signaling.
PHYSIOLOGICAL GENOMICS
(2022)
Review
Peripheral Vascular Disease
Zhen-Yu Zhang, Yu-Ling Yu, Kei Asayama, Tine W. Hansen, Gladys E. Maestre, Jan A. Staessen
Summary: Additional digital content is available in the text.
Article
Peripheral Vascular Disease
Chi D. Chu, Neil R. Powe, Charles E. McCulloch, Tanushree Banerjee, Deidra C. Crews, Rajiv Saran, Jennifer Bragg-Gresham, Hal Morgenstern, Meda E. Pavkov, Sharon H. Saydah, Delphine S. Tuot
Summary: This study observed a slight increase in the prevalence of albuminuria >= 300 mg/g among US adults with hypertension from 2001 to 2018, but no significant changes in the proportion receiving ACE inhibitor/ARB treatment. In the period from 2013 to 2018, the utilization of ACE inhibitor/ARB in adults with diabetes and albuminuria >= 300 mg/g was 55.3%, while it was 33.4% in those without diabetes.
Article
Peripheral Vascular Disease
Ye Feng, Kexin Peng, Renfei Luo, Fei Wang, Tianxin Yang
Summary: The activation of PRR contributes to elevated blood pressure during Ang II infusion by enhancing intrarenal RAS and renal medullary alpha-ENaC. The study found that S1P-derived sPRR mediates Ang II-induced hypertension through an increase in intrarenal renin levels and activation of ENaC.
Review
Biochemistry & Molecular Biology
Qiannan Gao, Li Xu, Jun Cai
Summary: Hypertension is a common cardiovascular disease globally, with resistant hypertension being difficult to control effectively. Current antihypertensive drugs may have adverse effects, highlighting the need for new therapeutic targets and treatments to manage hypertension and its comorbidities.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Medicine, Research & Experimental
Minela Aida Maranduca, Andreea Clim, Alin Constantin Pinzariu, Cristian Statescu, Radu Andy Sascau, Daniela Maria Tanase, Dragomir Nicolae Serban, Daniel Constantin Branisteanu, Daciana Elena Branisteanu, Bogdan Huzum, Ionela Lacramioara Serban
Summary: Chronic kidney disease (CKD) is a significant public health issue with irreversible loss of functional nephrons. Hypertension and diabetes are the main causes. The excessive activation of the renin angiotensin system leads to systemic and renal effects, resulting in high blood pressure and ultimately CKD. This review provides an overview of the pathophysiological associations between CKD, hypertension, and angiotensin II.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Peripheral Vascular Disease
Michihiro Satoh, Takuo Hirose, Hironori Satoh, Shingo Nakayama, Taku Obara, Takahisa Murakami, Tomoko Muroya, Kei Asayama, Masahiro Kikuya, Takefumi Mori, Yutaka Imai, Takayoshi Ohkubo, Hirohito Metoki
Summary: This observational retrospective cohort study investigates the effects of ARBs and dCCBs monotherapy on renal function. The results show that ARBs can be recommended for kidney protection in a primary care setting, while dCCB treatment initially increases estimated glomerular filtration rate (eGFR) with no adverse effects on proteinuria.
JOURNAL OF HYPERTENSION
(2022)
Review
Biochemistry & Molecular Biology
Robert M. Carey, Helmy M. Siragy, John J. Gildea, Susanna R. Keller
Summary: Angiotensin II (Ang II) type-2 receptors (AT(2)R) in the kidney play a crucial role in opposing renal sodium retention induced by Ang II stimulation of Ang II type-1 receptors (AT(1)R). AT(2)Rs induce natriuresis through the activation of bradykinin, nitric oxide, and cyclic GMP signaling cascade. Defects in AT(2)R activation and protein phosphatase 2A (PP2A) in spontaneously hypertensive rats are associated with primary hypertension.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Baojian Xue, Jun-Ling Cui, Fang Guo, Terry G. Beltz, Zi-Gang Zhao, Geng-Shen Zhang, Alan Kim Johnson
Summary: Exercise training has a beneficial role in preventing hypertensive response sensitization, by shifting the balance of prohypertensive and antihypertensive pathways in the brain, which leads to reduced central activity driving sympathetic outflow and blood pressure.
FRONTIERS IN NEUROSCIENCE
(2022)