Progressive MS: from pathophysiology to drug discovery

Mouse Models of Multiple Sclerosis: Lost in Translation?

(2015) David Baker et al.   CURRENT PHARMACEUTICAL DESIGN

A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

(2015) Aleksanteri Aspelund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Overcoming barriers in progressive multiple sclerosis research

(2015) Timothy Coetzee et al.   LANCET NEUROLOGY

A much-needed focus on progression in multiple sclerosis

(2015) Alan J Thompson   LANCET NEUROLOGY

Pathological mechanisms in progressive multiple sclerosis

(2015) Don H Mahad et al.   LANCET NEUROLOGY

Structural and functional features of central nervous system lymphatic vessels

(2015) Antoine Louveau et al.   NATURE

Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo

(2015) Fadi J. Najm et al.   NATURE

Meningeal inflammation in multiple sclerosis

(2015) Caterina Mainero et al.   NEUROLOGY

The Regulatory Machinery of Neurodegeneration in In Vitro Models of Amyotrophic Lateral Sclerosis

(2015) Burcin Ikiz et al.   Cell Reports

Assembly and Interrogation of Alzheimer’s Disease Genetic Networks Reveal Novel Regulators of Progression

(2015) Soline Aubry et al.   PLoS One

Fingolimod increases brain-derived neurotrophic factor levels and ameliorates amyloid β-induced memory impairment

(2014) Kazuya Fukumoto et al.   BEHAVIOURAL BRAIN RESEARCH

Building a pipeline to discover and validate novel therapeutic targets and lead compounds for Alzheimer's disease

(2014) David A. Bennett et al.   BIOCHEMICAL PHARMACOLOGY

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

(2014) Maggie S.Y. Yeung et al.   CELL

Identification of Causal Genetic Drivers of Human Disease through Systems-Level Analysis of Regulatory Networks

(2014) James C. Chen et al.   CELL

High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8+T cells

(2014) Andreas Lossius et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

(2014) Ping Shen et al.   NATURE

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

(2014) Lior Mayo et al.   NATURE MEDICINE

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Glial Development: The Crossroads of Regeneration and Repair in the CNS

(2014) Vittorio Gallo et al.   NEURON

Investigation of immune and CNS-mediated effects of fingolimod in the focal delayed-type hypersensitivity multiple sclerosis model

(2014) Daniel C. Anthony et al.   NEUROPHARMACOLOGY

Use of differentiated pluripotent stem cells in replacement therapy for treating disease

(2014) I. J. Fox et al.   SCIENCE

Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

(2013) Christopher Gardner et al.   BRAIN

Blocking LINGO-1 as a Therapy to Promote CNS Repair: From Concept to the Clinic

(2013) Sha Mi et al.   CNS DRUGS

The astrocyte in multiple sclerosis revisited

(2013) Celia F. Brosnan et al.   GLIA

FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease

(2013) Alba Di Pardo et al.   HUMAN MOLECULAR GENETICS

A regenerative approach to the treatment of multiple sclerosis

(2013) Vishal A. Deshmukh et al.   NATURE

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

(2013) Tobias Goldmann et al.   NATURE NEUROSCIENCE

Gray matter damage predicts the accumulation of disability 13 years later in MS

(2013) M. Filippi et al.   NEUROLOGY

Fingolimod Phosphate Attenuates Oligomeric Amyloid β–Induced Neurotoxicity via Increased Brain-Derived Neurotrophic Factor Expression in Neurons

(2013) Yukiko Doi et al.   PLoS One

iPSC-derived neural precursors exert a neuroprotective role in immune-mediated demyelination via the secretion of LIF

(2013) Cecilia Laterza et al.   Nature Communications

Increased CD8+ T Cell Response to Epstein-Barr Virus Lytic Antigens in the Active Phase of Multiple Sclerosis

(2013) Daniela F. Angelini et al.   PLoS Pathogens

Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination

(2012) Wolfgang Brück et al.   ACTA NEUROPATHOLOGICA

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

(2012) Tom A. Barr et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS

(2012) Robert J Fox et al.   Multiple Sclerosis Journal

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

(2012) Ayumi Yoshizaki et al.   NATURE

Leveraging models of cell regulation and GWAS data in integrative network-based association studies

(2012) Andrea Califano et al.   NATURE GENETICS

Will the real multiple sclerosis please stand up?

(2012) Peter K. Stys et al.   NATURE REVIEWS NEUROSCIENCE

Fingolimod, a sphingosine-1 phosphate receptor modulator, increases BDNF levels and improves symptoms of a mouse model of Rett syndrome

(2012) R. Deogracias et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

iCTNet: A Cytoscape plugin to produce and analyze integrative complex traits networks

(2011) Lili Wang et al.   BMC BIOINFORMATICS

CNS live imaging reveals a new mechanism of myelination: The liquid croissant model

(2011) Bettina Sobottka et al.   GLIA

Central nervous system myelin: structure, synthesis and assembly

(2011) Shweta Aggarwal et al.   TRENDS IN CELL BIOLOGY

Mitochondrial DNA deletions and neurodegeneration in multiple sclerosis

(2010) Graham R. Campbell et al.   ANNALS OF NEUROLOGY

Cortical lesions in multiple sclerosis

(2010) Massimiliano Calabrese et al.   Nature Reviews Neurology

Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?

(2009) Amit Bar-Or et al.   ANNALS OF NEUROLOGY

Rituximab in patients with primary progressive multiple sclerosis: Results of a randomized double-blind placebo-controlled multicenter trial

(2009) Kathleen Hawker et al.   ANNALS OF NEUROLOGY

MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47

(2009) Andreas Junker et al.   BRAIN

Intrathecal immune responses to EBV in early MS

(2009) Emilie Jaquiéry et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tumor necrosis factor-α-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

(2009) David Wheeler et al.   JOURNAL OF NEUROCHEMISTRY

Gray matter atrophy in multiple sclerosis: A longitudinal study

(2008) Elizabeth Fisher et al.   ANNALS OF NEUROLOGY

A defect of sphingolipid metabolism modifies the properties of normal appearing white matter in multiple sclerosis

(2008) David Wheeler et al.   BRAIN

HIV's double strike at the brain: neuronal toxicity and compromised neurogenesis

(2007) Marcus Kaul   Frontiers in Bioscience-Landmark