Eph-dependent cell-cell adhesion and segregation in development and cancer

The Eph-Receptor A7 Is a Soluble Tumor Suppressor for Follicular Lymphoma

(2011) Elisa Oricchio et al.   CELL

A Semisynthetic Eph Receptor Tyrosine Kinase Provides Insight into Ligand- Induced Kinase Activation

(2011) Nikhil Singla et al.   CHEMISTRY & BIOLOGY

CXCL12 (SDF1 )-CXCR4/CXCR7 Pathway Inhibition: An Emerging Sensitizer for Anticancer Therapies?

(2011) D. G. Duda et al.   CLINICAL CANCER RESEARCH

Ephrin-B reverse signaling controls septation events at the embryonic midline through separate tyrosine phosphorylation-independent signaling avenues

(2011) Christopher Dravis et al.   DEVELOPMENTAL BIOLOGY

Regulation of protein tyrosine phosphatases by reversible oxidation

(2011) Arne Östman et al.   JOURNAL OF BIOCHEMISTRY

Transsynaptic EphB/Ephrin-B Signaling Regulates Growth of Presynaptic Boutons Required for Classical Conditioning

(2011) W. Li et al.   JOURNAL OF NEUROSCIENCE

Cleavage of E-cadherin by ADAM10 mediates epithelial cell sorting downstream of EphB signalling

(2011) Guiomar Solanas et al.   NATURE CELL BIOLOGY

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses

(2011) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

Ephrin-Mediated cis-Attenuation of Eph Receptor Signaling Is Essential for Spinal Motor Axon Guidance

(2011) Tzu-Jen Kao et al.   NEURON

Ephrin-B3 binds to a sulfated cell-surface receptor

(2010) Halvor L. Holen et al.   BIOCHEMICAL JOURNAL

Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia

(2010) S.-Q. Kuang et al.   BLOOD

The EphB6 Receptor Cooperates with c-Cbl to Regulate the Behavior of Breast Cancer Cells

(2010) L. Truitt et al.   CANCER RESEARCH

EphB Signaling Directs Peripheral Nerve Regeneration through Sox2-Dependent Schwann Cell Sorting

(2010) Simona Parrinello et al.   CELL

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas

(2010) Séverine Roselli et al.   CELLULAR SIGNALLING

Ephrins and Eph receptors in stem cells and cancer

(2010) Maria Genander et al.   CURRENT OPINION IN CELL BIOLOGY

ADAM13 Induces Cranial Neural Crest by Cleaving Class B Ephrins and Regulating Wnt Signaling

(2010) Shuo Wei et al.   DEVELOPMENTAL CELL

Regulation of heart valve morphogenesis by Eph receptor ligand, ephrin-A1

(2010) Leslie A. Frieden et al.   DEVELOPMENTAL DYNAMICS

Ephrin-B1 forward signaling regulates craniofacial morphogenesis by controlling cell proliferation across Eph-ephrin boundaries

(2010) J. O. Bush et al.   GENES & DEVELOPMENT

Eph/ephrin molecules--a hub for signaling and endocytosis

(2010) M. E. Pitulescu et al.   GENES & DEVELOPMENT

Somatic mutations and germline sequence variants in patients with familial colorectal cancer

(2010) Alexandra E. Gylfe et al.   INTERNATIONAL JOURNAL OF CANCER

Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling

(2010) Kakajan Komurov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PTP1B regulates Eph receptor function and trafficking

(2010) Eva Nievergall et al.   JOURNAL OF CELL BIOLOGY

Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism

(2010) Nao Hiramoto-Yamaki et al.   JOURNAL OF CELL BIOLOGY

Ephrin-B2 regulates endothelial cell morphology and motility independently of Eph-receptor binding

(2010) M. L. Bochenek et al.   JOURNAL OF CELL SCIENCE

Eph receptor tyrosine kinases regulate astrocyte cytoskeletal rearrangement and focal adhesion formation

(2010) Till B. Puschmann et al.   JOURNAL OF NEUROCHEMISTRY

Astrocyte-Produced Ephrins Inhibit Schwann Cell Migration via VAV2 Signaling

(2010) F. T. Afshari et al.   JOURNAL OF NEUROSCIENCE

Diverse somatic mutation patterns and pathway alterations in human cancers

(2010) Zhengyan Kan et al.   NATURE

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells

(2010) Jonathan W. Astin et al.   NATURE CELL BIOLOGY

Signalling ballet in space and time

(2010) Boris N. Kholodenko et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

An extracellular steric seeding mechanism for Eph-ephrin signaling platform assembly

(2010) Elena Seiradake et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mutational Profiling of Kinases in Human Tumours of Pancreatic Origin Identifies Candidate Cancer Genes in Ductal and Ampulla of Vater Carcinomas

(2010) Vincenzo Corbo et al.   PLoS One

Ephrin-A5 and EphA5 Interaction Induces Synaptogenesis during Early Hippocampal Development

(2010) Yukio Akaneya et al.   PLoS One

Exploring the Link between Germline and Somatic Genetic Alterations in Breast Carcinogenesis

(2010) Núria Bonifaci et al.   PLoS One

Architecture of Eph receptor clusters

(2010) J. P. Himanen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restriction of Receptor Movement Alters Cellular Response: Physical Force Sensing by EphA2

(2010) K. Salaita et al.   SCIENCE

Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma

(2010) Xia Li et al.   TUMOR BIOLOGY

Axon Guidance Molecules in Vascular Patterning

(2010) R. H. Adams et al.   Cold Spring Harbor Perspectives in Biology

EphrinB reverse signaling in cell-cell adhesion

(2010) Hyun-Shik Lee et al.   Cell Adhesion & Migration

Axon Growth and Guidance: Receptor Regulation and Signal Transduction

(2009) Michael O'Donnell et al.   Annual Review of Neuroscience

Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptor

(2009) Nicole K. Noren et al.   BIOCHEMICAL JOURNAL

Regulation of Process Retraction and Cell Migration by EphA3 Is Mediated by the Adaptor Protein Nck1

(2009) Tianjing Hu et al.   BIOCHEMISTRY

EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures

(2009) O. Salvucci et al.   BLOOD

Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival

(2009) N I Herath et al.   BRITISH JOURNAL OF CANCER

EphA2 Mediates Ligand-Dependent Inhibition and Ligand-Independent Promotion of Cell Migration and Invasion via a Reciprocal Regulatory Loop with Akt

(2009) Hui Miao et al.   CANCER CELL

The Receptor Tyrosine Kinase EPHB4 Has Tumor Suppressor Activities in Intestinal Tumorigenesis

(2009) H. Dopeso et al.   CANCER RESEARCH

EphA2 Reexpression Prompts Invasion of Melanoma Cells Shifting from Mesenchymal to Amoeboid-like Motility Style

(2009) M. Parri et al.   CANCER RESEARCH

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

(2009) Maria Genander et al.   CELL

Cell adhesion and EGFR activation regulate EphA2 expression in cancer

(2009) Alice Bjerregaard Larsen et al.   CELLULAR SIGNALLING

Synapse development and plasticity: roles of ephrin/Eph receptor signaling

(2009) Kwok-On Lai et al.   CURRENT OPINION IN NEUROBIOLOGY

Control of extracellular matrix assembly along tissue boundaries via Integrin and Eph/Ephrin signaling

(2009) D. Julich et al.   DEVELOPMENT

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

(2009) Sara A Wickström et al.   EMBO JOURNAL

β2-Chimaerin binds to EphA receptors and regulates cell migration

(2009) Shingo Takeuchi et al.   FEBS LETTERS

Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism

(2009) J. O. Bush et al.   GENES & DEVELOPMENT

Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

(2009) Haina Qin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptic activity prompts γ-secretase–mediated cleavage of EphA4 and dendritic spine formation

(2009) Eiji Inoue et al.   JOURNAL OF CELL BIOLOGY

EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility

(2009) T. Yamazaki et al.   JOURNAL OF CELL SCIENCE

Focal Adhesion Kinase Acts Downstream of EphB Receptors to Maintain Mature Dendritic Spines by Regulating Cofilin Activity

(2009) Y. Shi et al.   JOURNAL OF NEUROSCIENCE

Ephrin-B3 reverse signaling through Grb4 and cytoskeletal regulators mediates axon pruning

(2009) Nan-Jie Xu et al.   NATURE NEUROSCIENCE

EphB2 and EphA4 receptors regulate formation of the principal inter-hemispheric tracts of the mammalian forebrain

(2009) S.K.Y. Ho et al.   NEUROSCIENCE

Expression of EphA2 and E-cadherin in Gastric Cancer: Correlated with Tumor Progression and Lymphogenous Metastasis

(2009) Weijie Yuan et al.   PATHOLOGY & ONCOLOGY RESEARCH

EphrinB2 coordinates the formation of a morphological boundary and cell epithelialization during somite segmentation

(2009) T. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cell-Specific Information Processing in Segregating Populations of Eph Receptor Ephrin-Expressing Cells

(2009) C. Jorgensen et al.   SCIENCE

Arterial-Venous Segregation by Selective Cell Sprouting: An Alternative Mode of Blood Vessel Formation

(2009) S. P. Herbert et al.   SCIENCE

Cytoplasmic Relaxation of Active Eph Controls Ephrin Shedding by ADAM10

(2009) Peter W. Janes et al.   PLOS BIOLOGY

Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1

(2008) Tessa N. Campbell et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Modulation of ephrinB2 leads to increased angiogenesis in ischemic myocardium and endothelial cell proliferation

(2008) Agneta Månsson-Broberg et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NMR Studies of a Heterotypic Sam−Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor†,‡

(2008) Marilisa Leone et al.   BIOCHEMISTRY

Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells

(2008) S. H. Wimmer-Kleikamp et al.   BLOOD

The role of Ephs, Ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade

(2008) J. S. Scehnet et al.   BLOOD

Eph-Ephrin Bidirectional Signaling in Physiology and Disease

(2008) Elena B. Pasquale   CELL

Eph/Ephrin Signalling and Function in Oncogenesis: Lessons from Embryonic Development

(2008) Peter Janes et al.   CURRENT CANCER DRUG TARGETS

Eph–ephrin signalling in adult tissues and cancer

(2008) Anna Merlos-Suárez et al.   CURRENT OPINION IN CELL BIOLOGY

Analysis of EphA4 receptor tyrosine kinase substrate specificity using peptide-based arrays

(2008) Neil Warner et al.   FEBS Journal

Aberrant methylation ofEphA7in human prostate cancer and its relation to clinicopathologic features

(2008) Ming Guan et al.   INTERNATIONAL JOURNAL OF CANCER

Fibronectin Type I Repeat Is a Nonactivating Ligand for EphA1 and Inhibits ATF3-dependent Angiogenesis

(2008) Junko Masuda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ephrin-B2-induced Cleavage of EphB2 Receptor Is Mediated by Matrix Metalloproteinases to Trigger Cell Repulsion

(2008) Kai-Ti Lin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Functional Analysis of Phosphorylated Tyrosine Residues within EphA2 Receptor Tyrosine Kinase

(2008) Wei Bin Fang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of EphB2 activation and cell repulsion by feedback control of the MAPK pathway

(2008) Alexei Poliakov et al.   JOURNAL OF CELL BIOLOGY

Induction of cell retraction by the combined actions of Abl–CrkII and Rho–ROCK1 signaling

(2008) XiaoDong Huang et al.   JOURNAL OF CELL BIOLOGY

Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism

(2008) W. B. Fang et al.   JOURNAL OF CELL SCIENCE

Involvement of endothelial ephrin-B2 in adhesion and transmigration of EphB-receptor-expressing monocytes

(2008) D. Pfaff et al.   JOURNAL OF CELL SCIENCE

The EphA3 receptor is expressed in a subset of rhabdomyosarcoma cell lines and suppresses cell adhesion and migration

(2008) Noretta Clifford et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling

(2008) Dana M. Brantley-Sieders et al.   JOURNAL OF CLINICAL INVESTIGATION

A TrkB/EphrinA Interaction Controls Retinal Axon Branching and Synaptogenesis

(2008) K. J. M. Marler et al.   JOURNAL OF NEUROSCIENCE

Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis

(2008) Yingchun Dong et al.   MODERN PATHOLOGY

Fibroblast Growth Factor Receptor-induced Phosphorylation of EphrinB1 Modulates Its Interaction with Dishevelled

(2008) Hyun-Shik Lee et al.   MOLECULAR BIOLOGY OF THE CELL

In Human Leukemia Cells Ephrin-B-Induced Invasive Activity Is Supported by Lck and Is Associated with Reassembling of Lipid Raft Signaling Complexes

(2008) G. Jiang et al.   MOLECULAR CANCER RESEARCH

EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line

(2008) J. Fukai et al.   MOLECULAR CANCER THERAPEUTICS

Somatic mutations affect key pathways in lung adenocarcinoma

(2008) Li Ding et al.   NATURE

EphrinB1 controls cell–cell junctions through the Par polarity complex

(2008) Hyun-Shik Lee et al.   NATURE CELL BIOLOGY

Bidirectional modulation of synaptic functions by Eph/ephrin signaling

(2008) Rüdiger Klein   NATURE NEUROSCIENCE

EphB Receptors Couple Dendritic Filopodia Motility to Synapse Formation

(2008) Matthew S. Kayser et al.   NEURON

p75NTR Mediates Ephrin-A Reverse Signaling Required for Axon Repulsion and Mapping

(2008) Yoo-Shick Lim et al.   NEURON

Germline EPHB2 Receptor Variants in Familial Colorectal Cancer

(2008) George Zogopoulos et al.   PLoS One

Heparan sulfate regulates ephrin-A3/EphA receptor signaling

(2008) F. Irie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Segregation of Axial Motor and Sensory Pathways via Heterotypic Trans-Axonal Signaling

(2008) B. W. Gallarda et al.   SCIENCE

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Autoregulation by the Juxtamembrane Region of the Human Ephrin Receptor Tyrosine Kinase A3 (EphA3)

(2008) Tara L. Davis et al.   STRUCTURE