Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts

Specificity of the dRP/AP Lyase of Ku Promotes Nonhomologous End Joining (NHEJ) Fidelity at Damaged Ends

(2012) Natasha Strande et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HMGN1 Protein Regulates Poly(ADP-ribose) Polymerase-1 (PARP-1) Self-PARylation in Mouse Fibroblasts

(2012) Aya Masaoka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Competition between PARP-1 and Ku70 control the decision between high-fidelity and mutagenic DNA repair

(2011) M.N. Paddock et al.   DNA REPAIR

Crystal Structures of Poly(ADP-ribose) Polymerase-1 (PARP-1) Zinc Fingers Bound to DNA

(2011) Marie-France Langelier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

(2011) C. Anne-Marie Couto et al.   JOURNAL OF CELL BIOLOGY

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks

(2011) Qiao Cheng et al.   NUCLEIC ACIDS RESEARCH

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

Poly(ADP-Ribose) Polymerase Is Hyperactivated in Homologous Recombination-Defective Cells

(2010) P. Gottipati et al.   CANCER RESEARCH

Alkylation DNA damage in combination with PARP inhibition results in formation of S-phase-dependent double-strand breaks

(2010) Michelle L. Heacock et al.   DNA REPAIR

The PARP Side of the Nucleus: Molecular Actions, Physiological Outcomes, and Clinical Targets

(2010) Raga Krishnakumar et al.   MOLECULAR CELL

Parp1 activation in mouse embryonic fibroblasts promotes Pol β-dependent cellular hypersensitivity to alkylation damage

(2010) Elena Jelezcova et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

(2010) Steven A. Roberts et al.   NATURE

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies

(2010) Wael Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

(2010) Farjana Fattah et al.   PLoS Genetics

Parthanatos, a messenger of death

(2009) Karen Kate David   Frontiers in Bioscience-Landmark

Cells deficient in PARP-1 show an accelerated accumulation of DNA single strand breaks, but not AP sites, over the PARP-1-proficient cells exposed to MMS

(2009) Brian F. Pachkowski et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

XRCC1 and DNA polymerase β in cellular protection against cytotoxic DNA single-strand breaks

(2008) Julie K Horton et al.   CELL RESEARCH

Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins

(2008) Ivan Ahel et al.   NATURE

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks

(2008) W. Y. Mansour et al.   NUCLEIC ACIDS RESEARCH

Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes

(2008) Jean-Philippe Gagné et al.   NUCLEIC ACIDS RESEARCH

Effect of double-strand break DNA sequence on the PARP-1 NHEJ pathway

(2007) Marc Audebert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS