Article
Pharmacology & Pharmacy
Wanlu Zhao, Guihuan Li, Qianbing Zhang, Meixuan Chen, Lijun He, Zhicong Wu, Yihe Zhang, Mingming Fan, Yanling Liang, Wenlong Zhang, Fangyin Zeng, Fan Deng
Summary: Cardiac glycoside neriifolin inhibits the malignancy of prostate cancer cells by activating endoplasmic reticulum stress (ERS), which increases DNA damage and apoptosis. This study found that neriifolin significantly inhibits cell growth and induces apoptosis in prostate cancer cells. Transcriptome sequence analysis shows that neriifolin induces DNA damage and double strand breaks (DSBs), and activates ERS pathway. Overall, Neriifolin may be a potential chemotherapeutic agent for prostate cancer treatment.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manami Semba, Shinji Takamatsu, Sachiko Komazawa-Sakon, Eiji Miyoshi, Chiharu Nishiyama, Hiroyasu Nakano, Kenta Moriwaki
Summary: The study identified proscillaridin A as a promising agent that enhances the anti-cancer efficacy of TRAIL therapeutics, particularly in colon cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Fan Yang, Sahana N. Bettadapura, Mark S. Smeltzer, Hua Zhu, Shanzhi Wang
Summary: This review discusses the roles of the gasdermin protein family in anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Review
Oncology
Mingxia Jiang, Ling Qi, Lisha Li, Yiming Wu, Dongfeng Song, Yanjing Li
Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Multidisciplinary Sciences
Asal Moradi, Mohammadreza Abdihaji, Sara Barari Kouchaksaraie, Tabarek Abdulrazaq Alkinani, Aida Mahmoudi, Arash Davoudi, William Dashtmiani, Somayeh Mikaeili Ghezeljeh, Shahrzad Aghajani, Reza Ghasemian, Somayeh Maghsoomi Taramsari, Amitis Majlesi, Zahra Mahdavi Niyaki, Ali Salehzadeh
Summary: The study aimed to fabricate Bi2O3/Gln-TSC nanoparticles and investigate their anticancer mechanism. The results showed that Bi2O3/Gln-TSC had significant cytotoxicity against prostate cancer cells and induced apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Hong-Ying Yang, Ya-Xiong Chen, Shangwen Luo, Yi-Lin He, Wei-Jiao Feng, Yue Sun, Jian-Jun Chen, Kun Gao
Summary: Fifteen cardiac glycosides (CGs) were isolated from Digitalis lanata Ehrh, including three new compounds (1-3). Their structures were determined and confirmed using various spectroscopic techniques. The cytotoxic activities of these CGs were evaluated against three human cancer cell lines, showing strong activities. Compound 1 was found to induce cell cycle arrest and inhibit the expression of vasohibin-2 (VASH2). Moreover, it exhibited concentration-dependent inhibition of angiogenesis in the chorioallantoic membrane (CAM) model.
Article
Agricultural Engineering
B. P. Bhusare, C. K. John, V. P. Bhatt, T. D. Nikam
Summary: The study demonstrates a promising method for inducing tetraploidy in Digitalis lanata shoots, resulting in higher content of cardiac glycosides digoxin and digitoxin. The tetraploids produced showed a significant increase in the content of these compounds compared to diploids. This has the potential to meet the growing demand for superior plant material in pharmaceutical industries.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Mehraban, Fariba Heidari Esfahani, Zahra Mosayebi Dorcheh, Erfaneh Heidari Esfahani, Mansoureh Azadeh, Ali Salehzadeh
Summary: This study evaluated the cytotoxic effect of GaFe2O4@Ag nanocomposite biosynthesized by Spirulina platensis on breast cancer cell line and investigated its influence on apoptosis pathways. The results showed that the nanocomposite exhibited high cytotoxicity against breast cancer cells and induced apoptosis through activation of apoptosis pathways.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Caitlin Hounsell, Yun Fan
Summary: Caspases play a crucial role in apoptosis initiation and are also involved in non-apoptotic functions like proliferation and differentiation. Altered caspase function in cancer can have both preventive and promoting effects on tumor formation, impacting cancer treatment strategies. A comprehensive understanding of the dual role of caspases is essential for the development of successful cancer therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Article
Chemistry, Analytical
Xin Yuan, Zhenxiao Niu, Lang Liu, Youjun Zeng, Lin Ma, Zhaogang Nie, Zhen Tian, Dongyun Kai, Fangteng Zhang, Guanyu Liu, Siwei Li, Zhengqiang Yuan
Summary: This study reports the development of a novel high-sensitivity ISPRi biosensor and its application in detecting apoptosis in cancer cells. By optimizing the excitation wavelength and angle, a high refractive index resolution was achieved. The biosensor has been validated for high-throughput and label-free detection of activated caspase-3 in apoptotic cells.
Review
Biochemistry & Molecular Biology
Asif Ahmad Bhat, Riya Thapa, Obaid Afzal, Neetu Agrawal, Waleed Hassan Almalki, Imran Kazmi, Sami I. Alzarea, Abdulmalik Saleh Alfawaz Altamimi, Parteek Prasher, Sachin Kumar Singh, Kamal Dua, Gaurav Gupta
Summary: Cytotoxic drugs kill cancer cells through apoptosis, but recent research has found that pyroptosis can inhibit cell proliferation and shrink tumors. Pyroptosis and apoptosis are caspase-dependent programmed cell death processes. Inflammasomes activate caspase-1 and latent cytokines, including IL-1 beta and IL-18, to induce pyroptosis by cleaving gasdermin E (GSDME). Understanding the cellular and molecular mechanisms of caspase-3 and GSDME-mediated programmed cell death, specifically pyroptosis, may lead to potential targets for cancer treatment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Shumin Li, Ming Yue, Haiyan Xu, Xiaofei Zhang, Tiebo Mao, Ming Quan, Jingyu Ma, Yanling Wang, Weiyu Ge, Yongchao Wang, Shengbai Xue, Daiyuan Shentu, Jiujie Cui, Liwei Wang
Summary: This study explores the mechanism of chemotherapy-induced pyroptosis and its role in mediating the progression and chemoresistance of pancreatic ductal adenocarcinoma (PDAC). It is found that first- and second-line chemotherapeutic drugs against PDAC induce concurrent pyroptosis and apoptosis. Moreover, it is demonstrated that pyroptosis promotes the invasiveness and chemoresistance of PDAC cells, and targeting pyroptosis can enhance the sensitivity of PDAC cells to chemotherapy.
Article
Cell Biology
Katarzyna A. Ludwik, Zachary M. Sandusky, Kimberly M. Stauffer, Yu Li, Kelli L. Boyd, George A. O'Doherty, Thomas P. Stricker, Deborah A. Lannigan
Article
Chemistry, Multidisciplinary
Ehesan U. Sharif, Pei Shi, George A. O'Doherty
Summary: Two unnatural regioisomeric glycosylated Gilvocarcin analogues were proposed as model compounds to study the biosynthetic origin of Gilvocarcins and the proposed O- to C-glycoside migration in the evolution of Angucycline antibiotics. The analogue with weak antibiotic activity compared to Gilvocarcin M was synthesized using a regio-divergent synthetic pathway with a Mitsunobu-like invertive cyclictolization reaction to install the carbasugar motif.
ISRAEL JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jessica Martins de Moura Valadares, Sumit O. Bajaj, Hongyan Li, Hua-Yu L. Wang, Simone Cavalcante Silva, Israel Jose Pereira Garcia, Duane Gischewiski Pereira, Pedro Azalim, Luis Eduardo Menezes Quintas, Francois Noel, Vanessa Faria Cortes, George Augustine O'Doherty, Leandro Augusto Barbosa
Summary: This study assessed the cytotoxic potential of novel digitoxigenin derivatives in cancer cells, showing higher cytotoxicity and selectivity in tumor cells compared to non-tumor cells. The derivatives were also found to modulate specific ATPases in a manner that suggests their importance in the cytotoxic effect on cancer cells.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Caitlyn L. Mills, Pengcheng Yin, Becky Leifer, Lori Ferrins, George A. O'Doherty, Penny J. Beuning, Mary Jo Ondrechen
Summary: This study investigates the functional characterization of eight structural genomics proteins from the Crotonase superfamily and uses the SALSA method for functional annotation. It is found that most of these proteins exhibit hydrolase activity in addition to their expected enoyl CoA hydratase activity.
ACS CHEMICAL BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Karol R. Francisco, Yu Li, Brent Lindquist-Kleissler, Jiamin Zheng, Yalan Xing, George A. O'Doherty
Summary: A one pot alkylative carboxylation reaction of 2-acetylfuran was developed for the synthesis of methyl beta-ketoesters. The beta-keto-ester product was used for the asymmetric synthesis of a C-7 pyranone precursor for a Pd-glycosylation reaction, with the ultimate goal of synthesizing natural products containing pyran rings, such as Aspergillide C.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Chemistry, Organic
Yanping Wang, George A. O'Doherty
Summary: An asymmetric approach for the total synthesis of the polyketide natural product EBC-23 is reported, involving a convergent strategy and a late-stage Claisen-like enolate/acid chloride coupling. The key 1,3-diketone intermediate was successfully established, and further transformations led to the synthesis of EBC-23.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Lisa Ngu, Debarpita Ray, Samantha S. Watson, Penny J. Beuning, Mary Jo Ondrechen, George A. O'Doherty
Summary: A diastereoselective synthesis of the beta-anomer of glycinamide ribonucleotide (beta-GAR) has been developed with a high overall yield. The synthetic beta-GAR demonstrated remarkable resistance to anomerization in both solution and solid state.
Article
Chemistry, Multidisciplinary
Yalan Xing, George A. O'Doherty
Summary: An asymmetric approach for synthesizing aspergillide-C has been developed, using asymmetric Noyori transfer hydrogenations to prepare the key fragments and establishing their absolute stereochemistry. The fragments were then coupled using a specific catalyzed reaction to form a protected variant of aspergillide-C.
Review
Chemistry, Multidisciplinary
Sugyeom Kim, Jeremy Oiler, Yalan Xing, George A. O'Doherty
Summary: The development and application of asymmetric synthesis of oligosaccharides from achiral starting materials are reviewed in this article. This approach involves the use of asymmetric catalysis to synthesize optically pure furan alcohols, in combination with Achmatowicz oxidative rearrangement for the synthesis of various pyranones. Additionally, diastereoselective palladium-catalyzed glycosylation and subsequent diastereoselective post-glycosylation transformation are used for the synthesis of oligosaccharides.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Yuzhi Ma, Rajender Vemula, Qi Zhang, Bulan Wu, George A. O'Doherty
Summary: The full account of a de novo asymmetric total synthesis of (+)-monanchorin, a guanidine alkaloid natural product, has been reported. The optimized synthesis route enables the access to both enantiomers of the compound in nine steps starting from the commodity chemicals furan and caproic acid. The synthesis relied on various reactions, including asymmetric Noyori hydrogen transfer reduction, Achmatowicz rearrangement, diastereoselective palladium-catalyzed glycosylation, reductive amination, and acid-catalyzed bicyclic guanidine mixed acetal formation.
GREEN SYNTHESIS AND CATALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Eric B. Wright, Shinji Fukuda, Mingzong Li, Yu Li, George A. O'Doherty, Deborah A. Lannigan
Summary: The study identified a natural product, SL0101, that binds specifically to RSK1/2 by inducing conformational rearrangement, but not to RSK3/4 due to a single amino acid difference. Kinetic analysis revealed that regions outside of the N-terminal kinase domain also contribute to stable inhibitor binding towards RSK2. Additionally, a modification on SL0101 was discovered to form a highly stable inhibitor complex with RSK2, suggesting potential for identifying RSK2-specific inhibitors.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Matthew Tcheng, Vitor L. S. Cunha, Nawaz Ahmed, Xiaofan Liu, Richard W. Smith, Kevin A. Rea, Tariq A. Akhtar, Angelo D'Alessandro, Mark D. Minden, Jerry Vockley, George A. O'Doherty, Todd L. Lowary, Paul A. Spagnuolo
Summary: This study conducted a structure-activity analysis on avocadyne, identifying specific structural features critical to suppressing mitochondrial fatty acid oxidation.
Article
Chemistry, Organic
Gao Dong, Bohui Li, George A. O'Doherty
ORGANIC CHEMISTRY FRONTIERS
(2020)
Review
Chemistry, Multidisciplinary
Alhanouf Z. Aljahdali, Kathryn A. Foster, George A. O'Doherty
CHEMICAL COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Reem Eldawud, Alixandra Wagner, Chenbo Dong, Neha Gupta, Yon Rojanasakul, George O'Doherty, Todd A. Stueckle, Cerasela Zoica Dinu
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2020)
